{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:27:07Z","timestamp":1790497627374,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":1361,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":87,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council of Australia","doi-asserted-by":"publisher","award":["1101620"],"award-info":[{"award-number":["1101620"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The French Society of Physical and Rehabilitation Medicine"},{"DOI":"10.13039\/100000005","name":"The United States Department of Defence","doi-asserted-by":"publisher","award":["W81XWH-15-1-0606"],"award-info":[{"award-number":["W81XWH-15-1-0606"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1101620"],"award-info":[{"award-number":["1101620"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201015\u20101\u20100606"],"award-info":[{"award-number":["W81XWH\u201015\u20101\u20100606"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Neurogenic heterotopic ossifications (NHOs) are incapacitating heterotopic bones in periarticular muscles that frequently develop following traumatic brain or spinal cord injuries (SCI). Using our unique model of SCI-induced NHO, we have previously established that mononucleated phagocytes infiltrating injured muscles are required to trigger NHO via the persistent release of the pro-inflammatory cytokine oncostatin M (OSM). Because neutrophils are also a major source of OSM, we investigated whether neutrophils also play a role in NHO development after SCI. We now show that surgery transiently increased granulocyte colony-stimulating factor (G-CSF) levels in blood of operated mice, and that G-CSF receptor mRNA is expressed in the hamstrings of mice developing NHO. However, mice defective for the G-CSF receptor gene Csf3r, which are neutropenic, have unaltered NHO development after SCI compared to C57BL\/6 control mice. Because the administration of recombinant human G-CSF (rhG-CSF) has been trialed after SCI to increase neuroprotection and neuronal regeneration and has been shown to suppress osteoblast function at the endosteum of skeletal bones in human and mice, we investigated the impact of a 7-day rhG-CSF treatment on NHO development. rhG-CSF treatment significantly increased neutrophils in the blood, bone marrow, and injured muscles. However, there was no change in NHO development compared to saline-treated controls. Overall, our results establish that unlike monocytes\/macrophages, neutrophils are dispensable for NHO development following SCI, and rhG-CSF treatment post-SCI does not impact NHO development. Therefore, G-CSF treatment to promote neuroregeneration is unlikely to adversely promote or affect NHO development in SCI patients. \u00a9 2020 American Society for Bone and Mineral Research.<\/jats:p>","DOI":"10.1002\/jbmr.4118","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T14:10:32Z","timestamp":1592835032000},"page":"2242-2251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neurogenic Heterotopic Ossifications Develop Independently of Granulocyte Colony-Stimulating Factor and Neutrophils"],"prefix":"10.1093","volume":"35","author":[{"given":"Hsu-Wen","family":"Tseng","sequence":"first","affiliation":[{"name":"Mater Research Institute, Translational Research Institute The University of Queensland Woolloongabba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kulina","sequence":"additional","affiliation":[{"name":"Mater Research Institute, Translational Research Institute The University of Queensland Woolloongabba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Salga","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) Garches France"},{"name":"Mater Research Institute, Translational Research Institute The University of Queensland Woolloongabba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Fleming","sequence":"additional","affiliation":[{"name":"Mater Research Institute, Translational Research Institute The University of Queensland Woolloongabba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedryck","family":"Vaquette","sequence":"additional","affiliation":[{"name":"Regenerative Medicine, Institute of Health and Biomedical Innovation Queensland University of Technology Kelvin Grove QLD Australia"},{"name":"School of Dentistry The University of Queensland Herston QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Gen\u00eat","sequence":"additional","affiliation":[{"name":"Evolution of Neuromuscular Diseases: Innovative Concepts and Practice (END:ICAP) U1179 Institut Natational de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 de Formation et de Recherche Simone Veil-Sant\u00e9 University of Versailles Saint Quentin en Yvelines Montigny-le-Bretonneux France"},{"name":"Department of Physical Medicine and Rehabilitation Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris (AP-HP) Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7299-6025","authenticated-orcid":false,"given":"Jean-Pierre","family":"Levesque","sequence":"additional","affiliation":[{"name":"Mater Research Institute, Translational Research Institute The University of Queensland Woolloongabba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5772-0277","authenticated-orcid":false,"given":"Kylie A","family":"Alexander","sequence":"additional","affiliation":[{"name":"Mater Research Institute, Translational Research Institute The University of Queensland Woolloongabba QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"issue":"1","key":"2024031503440811400_jbmr4118-bib-0001","doi-asserted-by":"crossref","first-page":"e16632","DOI":"10.1371\/journal.pone.0016632","article-title":"Troublesome heterotopic ossification after central nervous system damage: a survey of 570 surgeries","volume":"6","author":"Genet","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"2024031503440811400_jbmr4118-bib-0002","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.spinee.2017.04.021","article-title":"Muscle localization of heterotopic ossification following spinal cord injury","volume":"17","author":"Ohlmeier","year":"2017","journal-title":"Spine J"},{"issue":"7\u20138","key":"2024031503440811400_jbmr4118-bib-0003","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3109\/02699052.2013.775490","article-title":"Risk factors for developing heterotopic ossification in patients with traumatic brain injury","volume":"27","author":"Dizdar","year":"2013","journal-title":"Brain Inj"},{"issue":"1","key":"2024031503440811400_jbmr4118-bib-0004","first-page":"19","article-title":"Prevalence and risk-factors of neurogenic heterotopic ossification in traumatic spinal cord and traumatic brain injured patients admitted to specialised units in Australia","volume":"14","author":"Reznik","year":"2014","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"2018","key":"2024031503440811400_jbmr4118-bib-0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bone.2017.05.015","article-title":"Neurological heterotopic ossification: current understanding and future directions","volume":"109","author":"Brady","year":"2018","journal-title":"Bone"},{"issue":"5","key":"2024031503440811400_jbmr4118-bib-0006","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2106\/JBJS.H.00792","article-title":"Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors","volume":"91","author":"Forsberg","year":"2009","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"2024031503440811400_jbmr4118-bib-0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/16501970510027628","article-title":"Heterotopic ossification: a review","volume":"37","author":"Van den Bossche","year":"2005","journal-title":"J Rehabil Med"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0008","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00256-014-2003-6","article-title":"Sciatic nerve compression by neurogenic heterotopic ossification: use of CT to determine surgical indications","volume":"44","author":"Salga","year":"2014","journal-title":"Skeletal Radiol"},{"issue":"6","key":"2024031503440811400_jbmr4118-bib-0009","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/HTR.0b013e31822b54ba","article-title":"Impact of the operative delay and the degree of neurologic sequelae on recurrence of excised heterotopic ossification in patients with traumatic brain injury","volume":"27","author":"Genet","year":"2012","journal-title":"J Head Trauma Rehabil"},{"issue":"11","key":"2024031503440811400_jbmr4118-bib-0010","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1302\/0301-620X.91B11.22305","article-title":"Impact of late surgical intervention on heterotopic ossification of the hip after traumatic neurological injury","volume":"91","author":"Genet","year":"2009","journal-title":"J Bone Joint Surg Br"},{"issue":"7\u20138","key":"2024031503440811400_jbmr4118-bib-0011","first-page":"866","article-title":"Troublesome heterotopic ossification and stroke: features and risk factors. A case control study","volume":"29","author":"Gen\u00eat","year":"2018","journal-title":"Brain Injury"},{"issue":"8","key":"2024031503440811400_jbmr4118-bib-0012","doi-asserted-by":"crossref","first-page":"e23129","DOI":"10.1371\/journal.pone.0023129","article-title":"The impact of preoperative hip heterotopic ossification extent on recurrence in patients with head and spinal cord injury: a case control study","volume":"6","author":"Genet","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0013","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.4519","article-title":"Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle","volume":"236","author":"Gen\u00eat","year":"2015","journal-title":"J Pathol"},{"key":"2024031503440811400_jbmr4118-bib-0014","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3389\/fimmu.2019.00377","article-title":"Inhibition of JAK1\/2 tyrosine kinases reduces neurogenic heterotopic ossification after spinal cord injury","volume":"10","author":"Alexander","year":"2019","journal-title":"Front Immunol"},{"issue":"21","key":"2024031503440811400_jbmr4118-bib-0015","doi-asserted-by":"crossref","first-page":"e96034","DOI":"10.1172\/jci.insight.96034","article-title":"Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications","volume":"2","author":"Torossian","year":"2017","journal-title":"JCI Insight"},{"issue":"23","key":"2024031503440811400_jbmr4118-bib-0016","doi-asserted-by":"crossref","first-page":"9499","DOI":"10.1073\/pnas.86.23.9499","article-title":"The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo","volume":"86","author":"Lord","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"2024031503440811400_jbmr4118-bib-0017","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1182\/blood.V77.10.2154.2154","article-title":"Myeloid cell kinetics in mice treated with recombinant interleukin-3, granulocyte colony-stimulating factor (CSF), or granulocyte-macrophage CSF in vivo","volume":"77","author":"Lord","year":"1991","journal-title":"Blood"},{"issue":"6","key":"2024031503440811400_jbmr4118-bib-0018","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1182\/blood.V84.6.1737.1737","article-title":"Mice lacking granulocyte colony-stimulating factor have chronic neutropenia, granulocyte and macrophage progenitor cell deficiency, and impaired neutrophil mobilization","volume":"84","author":"Lieschke","year":"1994","journal-title":"Blood"},{"issue":"7","key":"2024031503440811400_jbmr4118-bib-0019","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1182\/blood.V90.7.2522","article-title":"The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand","volume":"90","author":"Liu","year":"1997","journal-title":"Blood"},{"issue":"5","key":"2024031503440811400_jbmr4118-bib-0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1074-7613(00)80504-X","article-title":"Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice","volume":"5","author":"Liu","year":"1996","journal-title":"Immunity"},{"issue":"17","key":"2024031503440811400_jbmr4118-bib-0021","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1182\/blood-2011-06-318220","article-title":"How I treat patients who mobilize hematopoietic stem cells poorly","volume":"118","author":"To","year":"2011","journal-title":"Blood"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0022","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12185-016-2162-4","article-title":"Cellular players of hematopoietic stem cell mobilization in the bone marrow niche","volume":"105","author":"Tay","year":"2017","journal-title":"Int J Hematol"},{"issue":"9","key":"2024031503440811400_jbmr4118-bib-0023","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1089\/neu.2006.23.1379","article-title":"Transplantation of bone marrow stem cells as well as mobilization by granulocyte-colony stimulating factor promotes recovery after spinal cord injury in rats","volume":"23","author":"Urdzikova","year":"2006","journal-title":"J Neurotrauma"},{"issue":"1","key":"2024031503440811400_jbmr4118-bib-0024","doi-asserted-by":"crossref","first-page":"e29880","DOI":"10.1371\/journal.pone.0029880","article-title":"Granulocyte-colony stimulating factor (G-CSF) improves motor recovery in the rat impactor model for spinal cord injury","volume":"7","author":"Dittgen","year":"2012","journal-title":"PLoS One"},{"key":"2024031503440811400_jbmr4118-bib-0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainres.2007.02.058","article-title":"Granulocyte colony-stimulating factor (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice","volume":"1149","author":"Koda","year":"2007","journal-title":"Brain Res"},{"key":"2024031503440811400_jbmr4118-bib-0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.01.047","article-title":"Granulocyte colony-stimulating factor improves alternative activation of microglia under microenvironment of spinal cord injury","volume":"238","author":"Guo","year":"2013","journal-title":"Neuroscience"},{"issue":"8","key":"2024031503440811400_jbmr4118-bib-0027","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/nen.0b013e3181257176","article-title":"Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice","volume":"66","author":"Nishio","year":"2007","journal-title":"J Neuropathol Exp Neurol"},{"issue":"4","key":"2024031503440811400_jbmr4118-bib-0028","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/j.1471-4159.2010.06659.x","article-title":"The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury","volume":"113","author":"Pitzer","year":"2010","journal-title":"J Neurochem"},{"issue":"4","key":"2024031503440811400_jbmr4118-bib-0029","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3171\/2011.5.SPINE10421","article-title":"Neuroprotective effects of granulocyte colony-stimulating factor and relationship to promotion of angiogenesis after spinal cord injury in rats: laboratory investigation","volume":"15","author":"Kawabe","year":"2011","journal-title":"J Neurosurg Spine"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/jcbfm.2014.208","article-title":"Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis","volume":"35","author":"de la Pena","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"2024031503440811400_jbmr4118-bib-0031","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1172\/JCI90647","article-title":"Bone marrow drives central nervous system regeneration after radiation injury","volume":"128","author":"Dietrich","year":"2018","journal-title":"J Clin Investig"},{"issue":"8","key":"2024031503440811400_jbmr4118-bib-0032","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1172\/JCI23559","article-title":"The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis","volume":"115","author":"Schneider","year":"2005","journal-title":"J Clin Invest"},{"issue":"12","key":"2024031503440811400_jbmr4118-bib-0033","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1007\/s00586-012-2213-3","article-title":"Neuroprotective therapy using granulocyte colony-stimulating factor for acute spinal cord injury: a phase I\/IIa clinical trial","volume":"21","author":"Takahashi","year":"2012","journal-title":"Eur Spine J"},{"issue":"4","key":"2024031503440811400_jbmr4118-bib-0034","first-page":"299","article-title":"Case report: combination therapy with Mesenchymal stem cells and granulocyte-Colony stimulating factor in a case of spinal cord injury","volume":"6","author":"Derakhshanrad","year":"2015","journal-title":"Basic Clin Neurosci"},{"issue":"3","key":"2024031503440811400_jbmr4118-bib-0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/BRS.0000000000000121","article-title":"Multicenter prospective nonrandomized controlled clinical trial to prove Neurotherapeutic effects of granulocyte Colony-stimulating factor for acute spinal cord injury: analyses of follow-up cases after at least 1\u2009year","volume":"39","author":"Inada","year":"2014","journal-title":"Spine"},{"issue":"Suppl 1","key":"2024031503440811400_jbmr4118-bib-0036","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.3727\/096368914X684943","article-title":"Comparison of neurological and functional outcomes after administration of granulocyte-colony-stimulating factor in motor-complete versus motor-incomplete postrehabilitated, chronic spinal cord injuries: a phase I\/II study","volume":"23","author":"Saberi","year":"2014","journal-title":"Cell Transplant"},{"issue":"7","key":"2024031503440811400_jbmr4118-bib-0037","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/japplphysiol.00797.2012","article-title":"Exercise delays neutrophil apoptosis by a G-CSF-dependent mechanism","volume":"113","author":"Mooren","year":"2012","journal-title":"J Appl Physiol (1985)"},{"issue":"5","key":"2024031503440811400_jbmr4118-bib-0038","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1152\/japplphysiol.00066.2007","article-title":"Granulocyte-colony stimulating factor enhances muscle proliferation and strength following skeletal muscle injury in rats","volume":"103","author":"Stratos","year":"2007","journal-title":"J Appl Physiol (1985)"},{"issue":"4","key":"2024031503440811400_jbmr4118-bib-0039","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1084\/jem.20101059","article-title":"G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation","volume":"208","author":"Hara","year":"2011","journal-title":"J Exp Med"},{"key":"2024031503440811400_jbmr4118-bib-0040","doi-asserted-by":"crossref","first-page":"6745","DOI":"10.1038\/ncomms7745","article-title":"G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy","volume":"6","author":"Hayashiji","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0041","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1084\/jem.20101700","article-title":"Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice","volume":"208","author":"Christopher","year":"2011","journal-title":"J Exp Med"},{"issue":"23","key":"2024031503440811400_jbmr4118-bib-0042","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1182\/blood-2009-11-253534","article-title":"Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs","volume":"116","author":"Winkler","year":"2010","journal-title":"Blood"},{"key":"2024031503440811400_jbmr4118-bib-0043","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fbioe.2018.00005","article-title":"Five days granulocyte colony-stimulating factor treatment increases bone formation and reduces gap size of a rat segmental bone defect: a pilot study","volume":"6","author":"Herrmann","year":"2018","journal-title":"Front Bioeng Biotechnol"},{"issue":"10","key":"2024031503440811400_jbmr4118-bib-0044","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1089\/ten.tea.2009.0268","article-title":"Bone regeneration properties of granulocyte colony-stimulating factor via neovascularization and osteogenesis","volume":"16","author":"Ishida","year":"2010","journal-title":"Tissue Eng Part A"},{"issue":"3","key":"2024031503440811400_jbmr4118-bib-0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood.V75.3.563.563","article-title":"A comparison of hematopoiesis in normal and splenectomized mice treated with granulocyte colony-stimulating factor","volume":"75","author":"Molineux","year":"1990","journal-title":"Blood"},{"key":"2024031503440811400_jbmr4118-bib-0046","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-1-61779-943-3_11","article-title":"Mobilization of hematopoietic stem cells by depleting bone marrow macrophages","volume":"904","author":"Barbier","year":"2012","journal-title":"Methods Mol Biol"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0047","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.4049\/jimmunol.181.2.1232","article-title":"Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo","volume":"181","author":"Chang","year":"2008","journal-title":"J Immunol"},{"issue":"3","key":"2024031503440811400_jbmr4118-bib-0048","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/jbm.a.32238","article-title":"Responses in vivo to purified poly(3-hydroxybutyrate-co-3-hydroxyvalerate) implanted in a murine tibial defect model","volume":"91A","author":"Wu","year":"2009","journal-title":"J Biomed Mater Res A"},{"issue":"4","key":"2024031503440811400_jbmr4118-bib-0049","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3171\/2010.4.SPINE09973","article-title":"Efficacy of the coadministration of granulocyte colony-stimulating factor and stem cell factor in the activation of intrinsic cells after spinal cord injury in mice","volume":"13","author":"Osada","year":"2010","journal-title":"J Neurosurg Spine"},{"issue":"6","key":"2024031503440811400_jbmr4118-bib-0050","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/jnr.23362","article-title":"Granulocyte colony-stimulating factor improves neuron survival in experimental spinal cord injury by regulating nucleophosmin-1 expression","volume":"92","author":"Guo","year":"2014","journal-title":"J Neurosci Res"},{"key":"2024031503440811400_jbmr4118-bib-0051","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fcell.2015.00048","article-title":"The granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity","volume":"3","author":"Wallner","year":"2015","journal-title":"Front Cell Develop Biol"},{"issue":"4","key":"2024031503440811400_jbmr4118-bib-0052","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00421-008-0946-9","article-title":"Administration of granulocyte colony-stimulating factor facilitates the regenerative process of injured mice skeletal muscle via the activation of Akt\/GSK3alphabeta signals","volume":"105","author":"Naito","year":"2009","journal-title":"Eur J Appl Physiol"},{"issue":"Suppl 1","key":"2024031503440811400_jbmr4118-bib-0053","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.3727\/096368913X672109","article-title":"Safety of granulocyte colony-stimulating factor (G-CSF) administration for postrehabilitated motor complete spinal cord injury patients: an open-label, phase I study","volume":"22","author":"Derakhshanrad","year":"2013","journal-title":"Cell Transplant"},{"issue":"9","key":"2024031503440811400_jbmr4118-bib-0054","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1182\/blood.V92.9.3465","article-title":"Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization","volume":"92","author":"Takamatsu","year":"1998","journal-title":"Blood"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0055","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2141.1994.tb04725.x","article-title":"Endogenous haemopoietic growth factors in neutropenia and infection","volume":"86","author":"Cebon","year":"1994","journal-title":"Br J Haematol"},{"issue":"10","key":"2024031503440811400_jbmr4118-bib-0056","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1182\/blood.V76.10.1962.1962","article-title":"Levels of serum granulocyte colony-stimulating factor in patients with infections","volume":"76","author":"Kawakami","year":"1990","journal-title":"Blood"},{"issue":"3","key":"2024031503440811400_jbmr4118-bib-0057","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"2024031503440811400_jbmr4118-bib-0058","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils","volume":"320","author":"Weiss","year":"1989","journal-title":"N Engl J Med"},{"issue":"3","key":"2024031503440811400_jbmr4118-bib-0059","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","article-title":"Neutrophils in tissue injury and repair","volume":"371","author":"Wang","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"2","key":"2024031503440811400_jbmr4118-bib-0060","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1172\/JCI15994","article-title":"Disruption of the CXCR4\/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide","volume":"111","author":"Levesque","year":"2003","journal-title":"J Clin Invest"},{"issue":"5","key":"2024031503440811400_jbmr4118-bib-0061","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0301-472X(02)00788-9","article-title":"Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment","volume":"30","author":"Levesque","year":"2002","journal-title":"Exp Hematol"},{"issue":"5","key":"2024031503440811400_jbmr4118-bib-0062","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1182\/blood.V98.5.1289","article-title":"Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor","volume":"98","author":"Levesque","year":"2001","journal-title":"Blood"},{"issue":"11","key":"2024031503440811400_jbmr4118-bib-0063","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1359\/jbmr.080612","article-title":"Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation","volume":"23","author":"Christopher","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024031503440811400_jbmr4118-bib-0064","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.phrs.2003.12.011","article-title":"Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model","volume":"50","author":"Kotto-Kome","year":"2004","journal-title":"Pharmacol Res"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.4118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asbmr.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jbmr.4118","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/35\/11\/2242\/55460346\/jbmr4118.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/35\/11\/2242\/55460346\/jbmr4118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T03:47:12Z","timestamp":1710474432000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/35\/11\/2242\/7516874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,22]]},"references-count":64,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,6,22]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4118","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,6,22]]},"assertion":[{"value":"2020-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}