{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:08:17Z","timestamp":1792382897039,"version":"4.4.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic kidney disease (CKD) disturbs mineral homeostasis, leading to mineral and bone disorders (MBD). CKD-MBD is a significant problem and currently available treatment options have important limitations. Phosphate retention is thought to be the initial cause of CKD-MBD but serum phosphate remains normal until the late stages of CKD, due to elevated levels of the phosphaturic hormone fibroblast growth factor-23 (FGF-23), and parathyroid hormone (PTH). Reduction of 1,25-dihydroxy-vitamin D (1,25[OH]2D) concentration is the next event in the adaptive response of the homeostatic system. We argue, and provide the rationale, that calcium retention which takes place concurrently with phosphate retention, could be the reason behind the hysteresis in the response of PTH. If indeed this is the case, intermittent administration of PTH in early CKD could prevent the hysteresis, which arguably leads to the development of secondary hyperparathyroidism, and provide the platform for an effective management of CKD-MBD. \u00a9 2020 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4155","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T23:01:09Z","timestamp":1597186869000},"page":"2313-2317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The CKD-MBD Syndrome: Hysteresis in PTH Involvement and PTH Administration for Its Management"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4670-0016","authenticated-orcid":false,"given":"Michael","family":"Pazianas","sequence":"first","affiliation":[{"name":"Institute of Musculoskeletal Sciences Oxford University Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D","family":"Miller","sequence":"additional","affiliation":[{"name":"Colorado Center for Bone Health Lakewood CO USA"},{"name":"University of Colorado Health Sciences Center Denver CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"issue":"1","key":"2024031419000603700_jbmr4155-bib-0001","first-page":"1","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","journal-title":"Kidney Int Suppl (2011)"},{"key":"2024031419000603700_jbmr4155-bib-0002","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1053\/j.ajkd.2013.03.009","article-title":"Lifetime incidence of CKD stages 3\u20135 in the United States","volume":"62","author":"Grams","year":"2013","journal-title":"Am J Kidney Dis"},{"key":"2024031419000603700_jbmr4155-bib-0003","author":"United States Renal Data System (USRDS)","year":"2017"},{"key":"2024031419000603700_jbmr4155-bib-0004","author":"Public Health England","year":"2014"},{"key":"2024031419000603700_jbmr4155-bib-0005","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","journal-title":"Kidney Int"},{"key":"2024031419000603700_jbmr4155-bib-0006","author":"Hogan","year":"2018"},{"key":"2024031419000603700_jbmr4155-bib-0007","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.bone.2004.06.014","article-title":"Bone as a source of FGF23: regulation by phosphate?","volume":"35","author":"Mirams","year":"2004","journal-title":"Bone"},{"issue":"7","key":"2024031419000603700_jbmr4155-bib-0008","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s40618-020-01205-9","article-title":"Phosphate-sensing and regulatory mechanism of FGF23 production","volume":"43","author":"Takashi","year":"2020","journal-title":"J Endocrinol Invest"},{"key":"2024031419000603700_jbmr4155-bib-0009","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJM197205182862009","article-title":"On the pathogenesis of the uremic state. 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