{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:11:00Z","timestamp":1786983060313,"version":"build-2736575974"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001765","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR056246"],"award-info":[{"award-number":["R01AR056246"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR073607"],"award-info":[{"award-number":["R01AR073607"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001765","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR056246"],"award-info":[{"award-number":["R01AR056246"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR073607"],"award-info":[{"award-number":["R01AR073607"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Smokers are at a higher risk of delayed union or nonunion after fracture repair. Few specific interventions are available for prevention because the molecular mechanisms that result in these negative sequelae are poorly understood. Murine models that mimic fracture healing in smokers are crucial in further understanding the local cellular and molecular alterations during fracture healing caused by smoking. We exposed three murine strains, C57BL\/6J, 129X1\/SvJ, and BALB\/cJ, to cigarette smoke for 3\u2009months before the induction of a midshaft transverse femoral osteotomy. We evaluated fracture healing 4\u2009weeks after the osteotomy using radiography, micro-computed tomography (\u03bcCT), and biomechanical testing. Radiographic analysis demonstrated a significant decrease in the fracture healing capacity of smoking 129X1\/SvJ mice. \u03bcCT results showed delayed remodeling of fracture calluses in all three strains after cigarette smoke exposure. Biomechanical testing indicated the most significant impairment in the functional properties of 129X1\/SvJ in comparison with C57BL\/6J and BALB\/cJ mice after cigarette smoke exposure. Thus, the 129X1\/SvJ strain is most suitable in simulating smoking-induced impaired fracture healing. Furthermore, in smoking 129X1\/SvJ murine models, we investigated the molecular and cellular alterations in fracture healing caused by cigarette smoking using histology, flow cytometry, and multiplex cytokine\/chemokine analysis. Histological analysis showed impaired chondrogenesis in cigarette smoking. In addition, the important reparative cell populations, including skeletal stem cells and their downstream progenitors, demonstrated decreased expansion after injury as a result of cigarette smoking. Moreover, significantly increased pro-inflammatory mediators and the recruitment of immune cells in fracture hematomas were demonstrated in smoking mice. Collectively, our findings demonstrate the significant cellular and molecular alterations during fracture healing impaired by smoking, including disrupted chondrogenesis, aberrant skeletal stem and progenitor cell activity, and a pronounced initial inflammatory response. \u00a9 2020 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4175","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T13:09:59Z","timestamp":1598879399000},"page":"186-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6499-3417","authenticated-orcid":false,"given":"Zichen","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Emergency and Trauma Changhai Hospital, Navy Medical University Shanghai China"},{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics The Second Hospital of Anhui Medical University Hefei China"},{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Guizhou Provincial People's Hospital Guiyang China"},{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareme D","family":"Alder","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean V","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana M","family":"Munger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inkyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Life Science Chung-Ang University Seoul Republic of Korea"},{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk-Kwon","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JungHo","family":"Back","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-4391","authenticated-orcid":false,"given":"Shuogui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency and Trauma Changhai Hospital, Navy Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine Pulmonary, Critical Care, and Sleep Medicine, Yale University, School of Medicine New Haven, CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2275-2441","authenticated-orcid":false,"given":"Francis Y","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation Yale University, School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"issue":"45","key":"2024012713541955200_jbmr4175-bib-0001","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.15585\/mmwr.mm6845a2","article-title":"Tobacco product use and cessation indicators among adults\u2014United States","volume":"68","author":"Creamer","year":"2019","journal-title":"Morb Mortal Wkly Rep."},{"issue":"9","key":"2024012713541955200_jbmr4175-bib-0002","doi-asserted-by":"crossref","first-page":"850","DOI":"10.2106\/JBJS.L.00375","article-title":"The musculoskeletal effects of cigarette smoking","volume":"95","author":"Lee","year":"2013","journal-title":"J Bone Joint Surg Am."},{"issue":"2","key":"2024012713541955200_jbmr4175-bib-0003","doi-asserted-by":"crossref","first-page":"63","DOI":"10.32098\/mltj.02.2013.03","article-title":"Cigarette smoking and musculoskeletal disorders","volume":"3","author":"Abate","year":"2013","journal-title":"Muscles Ligaments Tendons J."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0004","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3390\/jcm8030406","article-title":"Smoking dependent alterations in bone formation and inflammation represent major risk factors for complications following total joint arthroplasty","volume":"8","author":"Ehnert","year":"2019","journal-title":"J Clin Med."},{"key":"2024012713541955200_jbmr4175-bib-0005","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00003086-199908000-00024","article-title":"Effect of smoking on tibial shaft fracture healing","volume":"365","author":"Schmitz","year":"1999","journal-title":"Clin Orthop Relat Res."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0006","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00005131-200503000-00001","article-title":"Impact of smoking on fracture healing and risk of complications in limb-threatening open tibia fractures","volume":"19","author":"Castillo","year":"2005","journal-title":"J Orthop Trauma."},{"issue":"8","key":"2024012713541955200_jbmr4175-bib-0007","doi-asserted-by":"crossref","first-page":"674","DOI":"10.2106\/JBJS.M.00081","article-title":"Cigarette smoking increases complications following fracture: a systematic review","volume":"96","author":"Scolaro","year":"2014","journal-title":"J Bone Joint Surg Am."},{"key":"2024012713541955200_jbmr4175-bib-0008","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.actbio.2018.06.018","article-title":"Cigarette smoke increases pro-inflammatory markers and inhibits osteogenic differentiation in experimental exposure model","volume":"76","author":"Cyprus","year":"2018","journal-title":"Acta Biomater."},{"issue":"9","key":"2024012713541955200_jbmr4175-bib-0009","first-page":"2796","article-title":"Low-dose nicotine reduces the homing ability of murine BMSCs during fracture healing","volume":"10","author":"Zhang","year":"2018","journal-title":"Am J Transl Res."},{"key":"2024012713541955200_jbmr4175-bib-0010","volume-title":"How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease: a report of the surgeon general","author":"CDC","year":"2010"},{"issue":"5334","key":"2024012713541955200_jbmr4175-bib-0011","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1126\/science.277.5334.2002","article-title":"Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice","volume":"277","author":"Hautamaki","year":"1997","journal-title":"Science."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0012","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.taap.2014.10.010","article-title":"Through the smoke: use of in vivo and in vitro cigarette smoking models to elucidate its effect on female fertility","volume":"281","author":"Camlin","year":"2014","journal-title":"Toxicol Appl Pharmacol."},{"key":"2024012713541955200_jbmr4175-bib-0013","volume-title":"The health consequences of smoking\u201450\u2009years of progress: a report of the surgeon general","author":"CDC","year":"2014"},{"issue":"1","key":"2024012713541955200_jbmr4175-bib-0014","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat Rev Rheumatol."},{"issue":"5","key":"2024012713541955200_jbmr4175-bib-0015","doi-asserted-by":"crossref","first-page":"L662","DOI":"10.1152\/ajplung.00389.2017","article-title":"Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice","volume":"315","author":"Glynos","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0016","first-page":"629","article-title":"Development of the radiographic union score for tibial fractures for the assessment of tibial fracture healing after intramedullary fixation","volume":"68","author":"Whelan","year":"2010","journal-title":"J Trauma."},{"issue":"11","key":"2024012713541955200_jbmr4175-bib-0017","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1002\/jor.21148","article-title":"Fracture healing in mice under controlled rigid and flexible conditions using an adjustable external fixator","volume":"28","author":"R\u00f6ntgen","year":"2010","journal-title":"J Orthop Res."},{"issue":"1\u20132","key":"2024012713541955200_jbmr4175-bib-0018","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2014.12.002","article-title":"Identification and specification of the mouse skeletal stem cell","volume":"160","author":"Chan","year":"2015","journal-title":"Cell."},{"issue":"31","key":"2024012713541955200_jbmr4175-bib-0019","doi-asserted-by":"crossref","first-page":"12643","DOI":"10.1073\/pnas.1310212110","article-title":"Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells","volume":"110","author":"Chan","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"32","key":"2024012713541955200_jbmr4175-bib-0020","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1073\/pnas.1513066112","article-title":"Identification and characterization of an injury-induced skeletal progenitor","volume":"112","author":"Marecic","year":"2015","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"12","key":"2024012713541955200_jbmr4175-bib-0021","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/jbmr.3234","article-title":"Mast cells are critical regulators of bone fracture-induced inflammation and osteoclast formation and activity","volume":"32","author":"Kroner","year":"2017","journal-title":"J Bone Miner Res."},{"issue":"17","key":"2024012713541955200_jbmr4175-bib-0022","doi-asserted-by":"crossref","first-page":"8615","DOI":"10.1073\/pnas.1819218116","article-title":"Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via \u03b2-AR signaling","volume":"116","author":"Haffner-Luntzer","year":"2019","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2024012713541955200_jbmr4175-bib-0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acc.2014.09.001","article-title":"Biomarkers of tobacco smoke exposure","volume":"67","author":"Mattes","year":"2014","journal-title":"Adv Clin Chem."},{"issue":"2","key":"2024012713541955200_jbmr4175-bib-0024","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/aje\/kwn301","article-title":"Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial\/ethnic groups in the United States between 1999 and 2004","volume":"169","author":"Benowitz","year":"2009","journal-title":"Am J Epidemiol."},{"issue":"5","key":"2024012713541955200_jbmr4175-bib-0025","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1378\/chest.06-2179","article-title":"Systemic effects of smoking","volume":"131","author":"Yanbaeva","year":"2007","journal-title":"Chest."},{"key":"2024012713541955200_jbmr4175-bib-0026","first-page":"439396","article-title":"Smoking status effect on inflammatory markers in a randomized trial of current and former heavy smokers","volume":"2015","author":"Aldaham","year":"2015","journal-title":"Int J Inflam."},{"issue":"1","key":"2024012713541955200_jbmr4175-bib-0027","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/clpt.2011.105","article-title":"Cigarette smoking, nicotine, and body weight","volume":"90","author":"Audrain-McGovern","year":"2011","journal-title":"Clin Pharmacol Ther."},{"issue":"9","key":"2024012713541955200_jbmr4175-bib-0028","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1164\/rccm.200309-1270OC","article-title":"The development of emphysema in cigarette smoke-exposed mice is strain dependent","volume":"170","author":"Guerassimov","year":"2004","journal-title":"Am J Respir Crit Care Med."},{"issue":"6","key":"2024012713541955200_jbmr4175-bib-0029","doi-asserted-by":"crossref","first-page":"L519","DOI":"10.1152\/ajplung.00007.2012","article-title":"Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle","volume":"303","author":"Basic","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"2024012713541955200_jbmr4175-bib-0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22203\/eCM.v026a01","article-title":"Rodent animal models of delayed bone healing and non-union formation: a comprehensive review","volume":"26","author":"Garcia","year":"2013","journal-title":"Eur Cell Mater"},{"issue":"10","key":"2024012713541955200_jbmr4175-bib-0031","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/00005131-200411000-00006","article-title":"Characterization of a closed femur fracture model in mice","volume":"18","author":"Manigrasso","year":"2004","journal-title":"J Orthop Trauma."},{"issue":"21","key":"2024012713541955200_jbmr4175-bib-0032","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.2106\/JBJS.18.00035","article-title":"Experimental validation of the Radiographic Union Score for Tibial fractures (RUST) using micro-computed tomography scanning and biomechanical testing in an in-vivo rat model","volume":"100","author":"Fiset","year":"2018","journal-title":"J Bone Joint Surg Am."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0033","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/jor.23710","article-title":"Correlation between RUST assessments of fracture healing to structural and biomechanical properties","volume":"36","author":"Cooke","year":"2018","journal-title":"J Orthop Res."},{"key":"2024012713541955200_jbmr4175-bib-0034","doi-asserted-by":"crossref","first-page":"708574","DOI":"10.1155\/2014\/708574","article-title":"Current options for determining fracture union","volume":"2014","author":"Morshed","year":"2014","journal-title":"Adv Med."},{"issue":"6","key":"2024012713541955200_jbmr4175-bib-0035","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.bone.2012.03.008","article-title":"Micro-computed tomography assessment of the progression of fracture healing in mice","volume":"50","author":"O'Neill","year":"2012","journal-title":"Bone."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0036","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/03091909009015420","article-title":"Biomechanical measurement of fracture healing","volume":"14","author":"Cunningham","year":"1990","journal-title":"J Med Eng Technol."},{"issue":"12","key":"2024012713541955200_jbmr4175-bib-0037","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/jor.20263","article-title":"Smoking delays chondrogenesis in a mouse model of closed tibial fracture healing","volume":"24","author":"El-Zawawy","year":"2006","journal-title":"J Orthop Res."},{"key":"2024012713541955200_jbmr4175-bib-0038","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bone.2015.06.013","article-title":"Skeletal muscle-resident MSCs and bone formation","volume":"80","author":"Lemos","year":"2015","journal-title":"Bone."},{"issue":"12","key":"2024012713541955200_jbmr4175-bib-0039","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00264-013-2059-2","article-title":"Role of mesenchymal stem cells in bone regeneration and fracture repair: a review","volume":"37","author":"Wang","year":"2013","journal-title":"Int Orthop."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0040","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/jcp.22819","article-title":"Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene","volume":"227","author":"Kung","year":"2012","journal-title":"J Cell Physiol."},{"issue":"7724","key":"2024012713541955200_jbmr4175-bib-0041","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/d41586-018-06756-9","article-title":"Clear up this stem-cell mess","volume":"561","author":"Sipp","year":"2018","journal-title":"Nature."},{"issue":"1","key":"2024012713541955200_jbmr4175-bib-0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcyt.2018.11.007","article-title":"Response to nature commentary \"clear up this stem-cell mess\"","volume":"21","author":"Galipeau","year":"2019","journal-title":"Cytotherapy."},{"issue":"6","key":"2024012713541955200_jbmr4175-bib-0043","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1242\/dev.102210","article-title":"Skeletal stem cells","volume":"142","author":"Bianco","year":"2015","journal-title":"Development."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0044","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1083\/jcb.200509011","article-title":"Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population","volume":"172","author":"Morrison","year":"2006","journal-title":"J Cell Biol."},{"issue":"372","key":"2024012713541955200_jbmr4175-bib-0045","doi-asserted-by":"crossref","first-page":"eaag2809","DOI":"10.1126\/scitranslmed.aag2809","article-title":"Pharmacological rescue of diabetic skeletal stem cell niches","volume":"9","author":"Tevlin","year":"2017","journal-title":"Sci Transl Med."},{"issue":"7","key":"2024012713541955200_jbmr4175-bib-0046","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.it.2006.05.002","article-title":"Immunity and age: living in the past","volume":"27","author":"Woodland","year":"2006","journal-title":"Trends Immunol."},{"issue":"11","key":"2024012713541955200_jbmr4175-bib-0047","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1002\/jbmr.2373","article-title":"The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease","volume":"29","author":"Hadjiargyrou","year":"2014","journal-title":"J Bone Miner Res."},{"key":"2024012713541955200_jbmr4175-bib-0048","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00003086-199909000-00003","article-title":"Bone abnormalities in the surgical treatment of patients with rheumatoid arthritis","volume":"366","author":"Bogoch","year":"1999","journal-title":"Clin Orthop Relat Res."},{"issue":"12","key":"2024012713541955200_jbmr4175-bib-0049","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat Immunol."},{"issue":"4","key":"2024012713541955200_jbmr4175-bib-0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nri2062","article-title":"Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems","volume":"7","author":"Takayanagi","year":"2007","journal-title":"Nat Rev Immunol."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0051","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3390\/ijms18030583","article-title":"A pronounced inflammatory activity characterizes the early fracture healing phase in immunologically restricted patients","volume":"18","author":"Hoff","year":"2017","journal-title":"Int J Mol Sci."},{"issue":"5","key":"2024012713541955200_jbmr4175-bib-0052","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri2530","article-title":"How cigarette smoke skews immune responses to promote infection, lung disease and cancer","volume":"9","author":"St\u00e4mpfli","year":"2009","journal-title":"Nat Rev Immunol."},{"issue":"5","key":"2024012713541955200_jbmr4175-bib-0053","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","article-title":"Effects of cigarette smoke on the immune system","volume":"2","author":"Sopori","year":"2002","journal-title":"Nat Rev Immunol."},{"issue":"5","key":"2024012713541955200_jbmr4175-bib-0054","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/ijerph15051033","article-title":"Tobacco smoke induces and alters immune responses in the lung, triggering inflammation, allergy, asthma and other lung diseases: a mechanistic review","volume":"15","author":"Strzelak","year":"2018","journal-title":"Int J Environ Res Public Health."},{"key":"2024012713541955200_jbmr4175-bib-0055","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fendo.2017.00039","article-title":"Potential role of chemokines in fracture repair","volume":"8","author":"Edderkaoui","year":"2017","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"12","key":"2024012713541955200_jbmr4175-bib-0056","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1038\/cdd.2016.72","article-title":"IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells","volume":"23","author":"Xu","year":"2016","journal-title":"Cell Death Differ."},{"issue":"3","key":"2024012713541955200_jbmr4175-bib-0057","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1172\/JCI72030","article-title":"CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis","volume":"124","author":"Nouailles","year":"2014","journal-title":"J Clin Invest."},{"issue":"5","key":"2024012713541955200_jbmr4175-bib-0058","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/cmi.2013.19","article-title":"Translating translational research: mouse models of human disease","volume":"10","author":"Burkhardt","year":"2013","journal-title":"Cell Mol Immunol."},{"issue":"1","key":"2024012713541955200_jbmr4175-bib-0059","first-page":"170","article-title":"Mouse models of human disease: an evolutionary perspective","volume":"2016","author":"Perlman","year":"2016","journal-title":"Evol Med Public Health."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/1\/186\/55460072\/jbmr4175.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/1\/186\/55460072\/jbmr4175.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:06:01Z","timestamp":1710327961000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/36\/1\/186-198\/7516857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,8,31]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4175","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4175\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4175\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4175\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4175\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4175\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4175\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4175\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,8,31]]},"assertion":[{"value":"2020-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}