{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:56:14Z","timestamp":1787068574464,"version":"build-2736575974"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug reaction. Our previous whole-exome sequencing study found SIRT1 intronic region single-nucleotide polymorphism (SNP) rs7896005 to be associated with MRONJ in cancer patients treated with intravenous (iv) bisphosphonates (BPs). This study aimed to identify causal variants for this association. In silico analyses identified three SNPs (rs3758391, rs932658, and rs2394443) in the SIRT1 promoter region that are in high linkage disequilibrium (r2\u2009&amp;gt;\u20090.8) with rs7896005. To validate the association between these SNPs and MRONJ, we genotyped these three SNPs on the germline DNA from 104 cancer patients of European ancestry treated with iv BPs (46 cases and 58 controls). Multivariable logistic regression analysis showed the minor alleles of these three SNPs were associated with lower odds for MRONJ. The odds ratios (95% confidence interval) and p values were 0.351 (0.164\u20130.751; p = 0.007) for rs3758391, 0.351 (0.164\u20130.751; p = 0.007) for rs932658, and 0.331 (0.157\u20130.697; p = 0.0036) for rs2394443, respectively. In the reporter gene assays, constructs containing rs932658 with variant allele A had higher luciferase activity than the reference allele, whereas constructs containing SNP rs3758391 and\/or rs2394443 did not significantly affect activity. These results indicate that the promoter SNP rs932658 regulates the expression of SIRT1 and presumably lowers the risk of MRONJ by increasing SIRT1 expression. \u00a9 2020 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4185","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T17:42:48Z","timestamp":1600882968000},"page":"347-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["SIRT1 Gene SNP rs932658 Is Associated With Medication-Related Osteonecrosis of the Jaw"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-6523","authenticated-orcid":false,"given":"Guang","family":"Yang","sequence":"first","affiliation":[{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Collins","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya","family":"Rafiee","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Singh","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimour","family":"Langaee","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitrin W","family":"McDonough","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Shannon","family":"Holliday","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, College of Dentistry University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinder K","family":"Lamba","sequence":"additional","affiliation":[{"name":"UF Health Cancer Center Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Sick","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Microbiology College of Medicine, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Andrea","family":"Pelliccioni","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences Section of Dentistry-Alma Mater Studiorum-Universit\u00e0 di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaly","family":"Vaszilko","sequence":"additional","affiliation":[{"name":"Department of Oro-Maxillofacial Surgery and Stomatology Semmelweis University Dental School Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos P","family":"Kosa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadett","family":"Balla","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Moreb","sequence":"additional","affiliation":[{"name":"Novant Health Forsyth Medical Center, Hematology, Transplantation, and Cellular Therapy Division Winston-Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8218-1620","authenticated-orcid":false,"given":"Yan","family":"Gong","sequence":"additional","affiliation":[{"name":"UF Health Cancer Center Gainesville FL USA"},{"name":"Center for Pharmacogenomics and Precision Medicine College of Pharmacy, University of Florida Gainesville FL USA"},{"name":"Department of Pharmacotherapy and Translational Research College of Pharmacy, University of Florida Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"issue":"10","key":"2024012713524102100_jbmr4185-bib-0001","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw\u20132014 update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0002","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jbmr.2693","article-title":"Osteonecrosis of the jaw in the United States Food and Drug Administration's adverse event reporting system (FAERS)","volume":"31","author":"Zhang","year":"2016","journal-title":"J Bone Miner Res."},{"issue":"5","key":"2024012713524102100_jbmr4185-bib-0003","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ctrv.2015.04.007","article-title":"Drug induced osteonecrosis of the jaw","volume":"41","author":"Hamadeh","year":"2015","journal-title":"Cancer Treat Rev."},{"issue":"9","key":"2024012713524102100_jbmr4185-bib-0004","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: mechanism of action and role in clinical practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin Proc."},{"issue":"Suppl 3","key":"2024012713524102100_jbmr4185-bib-0005","first-page":"S1\u201332; quiz S3\u20135","article-title":"NCCN task force report: bone health in cancer care","volume":"7","author":"Gralow","year":"2009","journal-title":"J Natl Compr Canc Netw."},{"issue":"9","key":"2024012713524102100_jbmr4185-bib-0006","doi-asserted-by":"crossref","first-page":"e0185236","DOI":"10.1371\/journal.pone.0185236","article-title":"SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis","volume":"12","author":"Zainabadi","year":"2017","journal-title":"PLoS One."},{"issue":"9","key":"2024012713524102100_jbmr4185-bib-0007","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J Oral Maxillofac Surg."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0008","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jbmr.2405","article-title":"Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus","volume":"30","author":"Khan","year":"2015","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0009","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.joms.2009.03.050","article-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","volume":"68","author":"Lo","year":"2010","journal-title":"J Oral Maxillofac Surg."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00774-011-0299-z","article-title":"An epidemiological study of alendronate-related osteonecrosis of the jaws. A case series from the south-east of Scotland with attention given to case definition and prevalence","volume":"30","author":"Malden","year":"2012","journal-title":"J Bone Miner Metab."},{"issue":"11","key":"2024012713524102100_jbmr4185-bib-0011","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.14219\/jada.archive.2010.0082","article-title":"The incidence of osteonecrosis of the jaw in patients receiving 5 milligrams of zoledronic acid: data from the health outcomes and reduced incidence with zoledronic acid once yearly clinical trials program","volume":"141","author":"Grbic","year":"2010","journal-title":"J Am Dent Assoc."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0012","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00520-015-2904-5","article-title":"Safety of long-term denosumab therapy: results from the open label extension phase of two phase 3 studies in patients with metastatic breast and prostate cancer","volume":"24","author":"Stopeck","year":"2016","journal-title":"Support Care Cancer."},{"issue":"5","key":"2024012713524102100_jbmr4185-bib-0013","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/annonc\/mdr435","article-title":"Incidence, risk factors, and outcomes of osteonecrosis of the jaw: integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases","volume":"23","author":"Saad","year":"2012","journal-title":"Ann Oncol."},{"issue":"34","key":"2024012713524102100_jbmr4185-bib-0014","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1200\/JCO.2005.02.8670","article-title":"Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors","volume":"23","author":"Bamias","year":"2005","journal-title":"J Clin Oncol."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1056\/NEJM200507073530120","article-title":"Osteonecrosis of the jaw and bisphosphonates","volume":"353","author":"Durie","year":"2005","journal-title":"N Engl J Med."},{"issue":"32","key":"2024012713524102100_jbmr4185-bib-0016","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1200\/JCO.2009.21.9584","article-title":"Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw","volume":"27","author":"Vahtsevanos","year":"2009","journal-title":"J Clin Oncol."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0017","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10147-013-0561-6","article-title":"Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials","volume":"19","author":"Qi","year":"2014","journal-title":"Int J Clin Oncol."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0018","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10549-011-1429-y","article-title":"Safety of zoledronic acid and incidence of osteonecrosis of the jaw (ONJ) during adjuvant therapy in a randomised phase III trial (AZURE: BIG 01-04) for women with stage II\/III breast cancer","volume":"127","author":"Coleman","year":"2011","journal-title":"Breast Cancer Res Treat"},{"issue":"5 Suppl","key":"2024012713524102100_jbmr4185-bib-0019","first-page":"2","article-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws\u20132009 update","volume":"67","author":"Ruggiero","year":"2009","journal-title":"J Oral Maxillofac Surg."},{"issue":"8","key":"2024012713524102100_jbmr4185-bib-0020","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.14219\/jada.archive.2006.0355","article-title":"Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations","volume":"137","author":"American Dental Association Council on Scientific Affairs","year":"2006","journal-title":"J Am Dent Assoc."},{"issue":"4","key":"2024012713524102100_jbmr4185-bib-0021","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2141.2011.08622.x","article-title":"A peroxisome proliferator-activated receptor gamma (PPARG) polymorphism is associated with zoledronic acid-related osteonecrosis of the jaw in multiple myeloma patients: analysis by DMET microarray profiling","volume":"154","author":"Di Martino","year":"2011","journal-title":"Br J Haematol."},{"issue":"6","key":"2024012713524102100_jbmr4185-bib-0022","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ijom.2011.02.002","article-title":"Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw","volume":"40","author":"Katz","year":"2011","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0023","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jcms.2012.10.018","article-title":"Major histocompatibility complex class II polymorphisms are associated with the development of anti-resorptive agent-induced osteonecrosis of the jaw","volume":"41","author":"Stockmann","year":"2013","journal-title":"J Craniomaxillofac Surg."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0024","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2217\/bmm.12.14","article-title":"An aromatase polymorphism (g.132810C&gt;T) predicts risk of bisphosphonate-related osteonecrosis of the jaw","volume":"6","author":"La Ferla","year":"2012","journal-title":"Biomark Med."},{"issue":"7","key":"2024012713524102100_jbmr4185-bib-0025","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1182\/blood-2008-04-147884","article-title":"Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis","volume":"112","author":"Sarasquete","year":"2008","journal-title":"Blood"},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0026","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1634\/theoncologist.2011-0202","article-title":"Genomewide pharmacogenetics of bisphosphonate-induced osteonecrosis of the jaw: the role of RBMS3","volume":"17","author":"Nicoletti","year":"2012","journal-title":"Oncologist."},{"key":"2024012713524102100_jbmr4185-bib-0027","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bone.2019.04.010","article-title":"Pharmacogenomics of osteonecrosis of the jaw","volume":"124","author":"Yang","year":"2019","journal-title":"Bone."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0028","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jbmr.3285","article-title":"SIRT1\/HERC4 locus associated with bisphosphonate-induced osteonecrosis of the jaw: an exome-wide association analysis","volume":"33","author":"Yang","year":"2018","journal-title":"J Bone Miner Res."},{"issue":"6771","key":"2024012713524102100_jbmr4185-bib-0029","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35001622","article-title":"Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase","volume":"403","author":"Imai","year":"2000","journal-title":"Nature."},{"key":"2024012713524102100_jbmr4185-bib-0030","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1038\/npjamd.2016.17","article-title":"It takes two to tango: NAD","volume":"2","author":"Imai","year":"2016","journal-title":"NPJ Aging Mech Dis."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0031","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/abbs\/gms108","article-title":"SIRT1 and energy metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Acta Biochim Biophys Sin (Shanghai)."},{"issue":"10","key":"2024012713524102100_jbmr4185-bib-0032","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell Signal."},{"issue":"1\u20132","key":"2024012713524102100_jbmr4185-bib-0033","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1615\/CritRevOncog.2014012374","article-title":"Multifaceted modulation of SIRT1 in cancer and inflammation","volume":"20","author":"Yang","year":"2015","journal-title":"Crit Rev Oncog."},{"issue":"10","key":"2024012713524102100_jbmr4185-bib-0034","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1210\/me.2015-1133","article-title":"Sirtuin1 suppresses osteoclastogenesis by deacetylating FoxOs","volume":"29","author":"Kim","year":"2015","journal-title":"Mol Endocrinol."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.yexcr.2016.04.010","article-title":"SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation","volume":"344","author":"Duncan","year":"2016","journal-title":"Exp Cell Res."},{"key":"2024012713524102100_jbmr4185-bib-0036","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.phrs.2019.03.007","article-title":"Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders?","volume":"143","author":"Zainabadi","year":"2019","journal-title":"Pharmacol Res."},{"issue":"1\u20132","key":"2024012713524102100_jbmr4185-bib-0037","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11010-018-3477-7","article-title":"Sirtuin 1 inhibits TNF-\u03b1-mediated osteoclastogenesis of bone marrow-derived macrophages through both ROS generation and TRPV1 activation","volume":"455","author":"Yan","year":"2019","journal-title":"Mol Cell Biochem."},{"issue":"21","key":"2024012713524102100_jbmr4185-bib-0038","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","article-title":"LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants","volume":"31","author":"Machiela","year":"2015","journal-title":"Bioinformatics."},{"issue":"6","key":"2024012713524102100_jbmr4185-bib-0039","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"Consortium","year":"2013","journal-title":"Nat Genet."},{"issue":"8","key":"2024012713524102100_jbmr4185-bib-0040","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/bioinformatics\/btu779","article-title":"SNiPA: an interactive, genetic variant-centered annotation browser","volume":"31","author":"Arnold","year":"2015","journal-title":"Bioinformatics."},{"issue":"4","key":"2024012713524102100_jbmr4185-bib-0041","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1101\/gr.159624.113","article-title":"Centromere reference models for human chromosomes X and Y satellite arrays","volume":"24","author":"Miga","year":"2014","journal-title":"Genome Res."},{"issue":"W1","key":"2024012713524102100_jbmr4185-bib-0042","first-page":"W109\u201313","article-title":"SNPnexus: assessing the functional relevance of genetic variation to facilitate the promise of precision medicine","volume":"46","author":"Dayem Ullah","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"Database issue","key":"2024012713524102100_jbmr4185-bib-0043","doi-asserted-by":"crossref","first-page":"D930","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"7414","key":"2024012713524102100_jbmr4185-bib-0044","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"ENCODE Project Consortium","year":"2012","journal-title":"Nature."},{"issue":"D1","key":"2024012713524102100_jbmr4185-bib-0045","doi-asserted-by":"crossref","first-page":"D794\u2013D01","DOI":"10.1093\/nar\/gkx1081","article-title":"The encyclopedia of DNA elements (ENCODE): data portal update","volume":"46","author":"Davis","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"2024012713524102100_jbmr4185-bib-0046","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res."},{"issue":"D1","key":"2024012713524102100_jbmr4185-bib-0047","doi-asserted-by":"crossref","first-page":"D754\u2013D61","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2024012713524102100_jbmr4185-bib-0048","doi-asserted-by":"crossref","first-page":"e0206239","DOI":"10.1371\/journal.pone.0206239","article-title":"miRWalk: an online resource for prediction of microRNA binding sites","volume":"13","author":"Sticht","year":"2018","journal-title":"PLoS One."},{"issue":"8","key":"2024012713524102100_jbmr4185-bib-0049","doi-asserted-by":"crossref","first-page":"e05005","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife."},{"issue":"Database issue","key":"2024012713524102100_jbmr4185-bib-0050","first-page":"D86\u201391","article-title":"PolymiRTS database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways","volume":"42","author":"Bhattacharya","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"2024012713524102100_jbmr4185-bib-0051","doi-asserted-by":"crossref","first-page":"D155\u201362","DOI":"10.1093\/nar\/gky1141","article-title":"miRBase: from microRNA sequences to function","volume":"47","author":"Kozomara","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"Database issue","key":"2024012713524102100_jbmr4185-bib-0052","first-page":"D146\u201352","article-title":"miRDB: an online resource for microRNA target prediction and functional annotations","volume":"43","author":"Wong","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0053","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13059-019-1629-z","article-title":"Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data","volume":"20","author":"Liu","year":"2019","journal-title":"Genome Biol."},{"issue":"9","key":"2024012713524102100_jbmr4185-bib-0054","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gkp215","article-title":"Human splicing finder: an online bioinformatics tool to predict splicing signals","volume":"37","author":"Desmet","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"2024012713524102100_jbmr4185-bib-0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.gene.2005.07.015","article-title":"Characterization and prediction of alternative splice sites","volume":"366","author":"Wang","year":"2006","journal-title":"Gene."},{"issue":"1\u20132","key":"2024012713524102100_jbmr4185-bib-0056","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mrfmmm.2004.07.023","article-title":"Genetic variation analyses by pyrosequencing","volume":"573","author":"Langaee","year":"2005","journal-title":"Mutat Res."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0057","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13059-018-1519-9","article-title":"The 3D genome browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions","volume":"19","author":"Wang","year":"2018","journal-title":"Genome Biol."},{"issue":"4","key":"2024012713524102100_jbmr4185-bib-0058","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nbt.3158","article-title":"Epigenomic annotation of genetic variants using the roadmap epigenome browser","volume":"33","author":"Zhou","year":"2015","journal-title":"Nat Biotechnol."},{"issue":"4","key":"2024012713524102100_jbmr4185-bib-0059","first-page":"26818","article-title":"Intronic microRNA (miRNA)","volume":"2006","author":"Lin","year":"2006","journal-title":"J Biomed Biotechnol."},{"issue":"12","key":"2024012713524102100_jbmr4185-bib-0060","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1261\/rna.045633.114","article-title":"Cellular microRNAs up-regulate transcription via interaction with promoter TATA-box motifs","volume":"20","author":"Zhang","year":"2014","journal-title":"RNA"},{"issue":"47","key":"2024012713524102100_jbmr4185-bib-0061","doi-asserted-by":"crossref","first-page":"77707","DOI":"10.18632\/oncotarget.12774","article-title":"SIRT1 suppresses adipogenesis by activating Wnt\/\u03b2-catenin signaling in vivo and in vitro","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget."},{"issue":"10","key":"2024012713524102100_jbmr4185-bib-0062","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s11626-016-0070-9","article-title":"SIRT1 was involved in TNF-\u03b1-promoted osteogenic differentiation of human DPSCs through Wnt\/\u03b2-catenin signal","volume":"52","author":"Feng","year":"2016","journal-title":"In Vitro Cell Dev Biol Anim."},{"issue":"5","key":"2024012713524102100_jbmr4185-bib-0063","doi-asserted-by":"crossref","first-page":"e0178520","DOI":"10.1371\/journal.pone.0178520","article-title":"SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2","volume":"12","author":"Zainabadi","year":"2017","journal-title":"PLoS One."},{"issue":"10","key":"2024012713524102100_jbmr4185-bib-0064","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.mad.2005.04.006","article-title":"The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals","volume":"126","author":"Lemieux","year":"2005","journal-title":"Mech Ageing Dev."},{"issue":"1","key":"2024012713524102100_jbmr4185-bib-0065","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1128\/MCB.23.1.38-54.2003","article-title":"The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis","volume":"23","author":"McBurney","year":"2003","journal-title":"Mol Cell Biol."},{"issue":"19","key":"2024012713524102100_jbmr4185-bib-0066","doi-asserted-by":"crossref","first-page":"10794","DOI":"10.1073\/pnas.1934713100","article-title":"Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice","volume":"100","author":"Cheng","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2024012713524102100_jbmr4185-bib-0067","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/jbmr.1824","article-title":"Silent information regulator (Sir)T1 inhibits NF-\u03baB signaling to maintain normal skeletal remodeling","volume":"28","author":"Edwards","year":"2013","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024012713524102100_jbmr4185-bib-0068","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/emmm.201201606","article-title":"SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating \u03b2-catenin","volume":"5","author":"Simic","year":"2013","journal-title":"EMBO Mol Med."},{"issue":"9","key":"2024012713524102100_jbmr4185-bib-0069","doi-asserted-by":"crossref","first-page":"e46364","DOI":"10.1371\/journal.pone.0046364","article-title":"SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-\u03baB activity","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS One."},{"issue":"4","key":"2024012713524102100_jbmr4185-bib-0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"Vallabhapurapu","year":"2009","journal-title":"Annu Rev Immunol."},{"key":"2024012713524102100_jbmr4185-bib-0071","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2020.4564","article-title":"NED416, a novel synthetic Sirt1 activator, promotes cutaneous wound healing via the MAPK\/Rho pathway","author":"Wahedi","year":"2020","journal-title":"Int J Mol Med."},{"key":"2024012713524102100_jbmr4185-bib-0072","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40780-015-0035-2","article-title":"Analysis of the time-to-onset of osteonecrosis of jaw with bisphosphonate treatment using the data from a spontaneous reporting system of adverse drug events","volume":"1","author":"Nakamura","year":"2015","journal-title":"J Pharm Health Care Sci."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/2\/347\/55457618\/jbmr4185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/2\/347\/55457618\/jbmr4185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:06:08Z","timestamp":1710327968000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/36\/2\/347-356\/7516675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,9,23]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4185","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4185\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4185\/v3\/response1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,9,23]]},"assertion":[{"value":"2020-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}