{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:57:26Z","timestamp":1789772246904,"version":"4.0.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T00:00:00Z","timestamp":1604016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish government grant- ALF-agreement"},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism (PHPT) was previously considered a disease presenting with multiorgan involvement and a wide range of symptoms. Today, the disease presents with no symptoms or mild symptomatology in most patients. Data regarding nonspecific symptoms such as pain, fatigue, memory loss, depression, and other neuropsychiatric signs have been ambiguous, and results from prospective long-term randomized control trials are lacking. The Scandinavian Investigation on Primary Hyperparathyroidism (SIPH) is a prospective randomized controlled trial (RCT) with 10-year follow up, comparing parathyroidectomy (PTX) to observation without any treatment (OBS). From 1998 to 2005, 191 patients with mild PHPT were included from Sweden, Norway, and Denmark. A total of 95 patients were randomized to PTX and 96 to OBS. The generic Short Form-36 survey (SF-36) and the Comprehensive Psychopathological Rating Scale (CPRS) were studied at baseline, 2, 5, and 10\u2009years after randomization. After 10\u2009years, the PTX group scored significantly better on vitality (PTX 65.1\u2009\u00b1\u200920.2 versus OBS 57.4\u2009\u00b1\u200922.7; p =\u2009.017) compared to the OBS group in SF-36. We found no differences between the groups in the physical subscales. The OBS group had no significant change in any of the SF-36 scores throughout the study. The CPRS showed an improvement of symptoms in both groups for single items and sum scores after 10\u2009years compared to baseline. There were, however, no significant differences between the two groups in the CPRS data. The results of this large and long-term RCT indicate improvement in some of the mental domains of SF-36 following PTX. However, the treatment effects between the groups were subtle with uncertain clinical significance. The observation group had stable SF-36 values and improvement in CPRS symptom-scores. Thus, in considering only quality of life (QoL) and in the absence of declines in renal and skeletal parameters, it may be safe to observe patients with mild PHPT for a decade. \u00a9 2020 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4199","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T15:49:18Z","timestamp":1604072958000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Effects of Parathyroidectomy on Quality of Life: 10\u2009Years of Data From a Prospective Randomized Controlled Trial on Primary Hyperparathyroidism (the SIPH-Study)"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-5116","authenticated-orcid":false,"given":"Mikkel","family":"Pretorius","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Section of Specialized 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W","family":"Fagerland","sequence":"additional","affiliation":[{"name":"Oslo Centre for Biostatistics and Epidemiology, Research Support Services Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-3657","authenticated-orcid":false,"given":"Kristin","family":"Godang","sequence":"additional","affiliation":[{"name":"Section of Specialized Endocrinology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Mollerup","sequence":"additional","affiliation":[{"name":"Clinic of Breast and Endocrine Surgery, HovedOrtoCentret (HOC) Copenhagen University Hospital, Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1626-4169","authenticated-orcid":false,"given":"Stine L","family":"Fougner","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Clinic of Medicine St. Olavs Hospital, Trondheim University Hospital Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Pernow","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Department of Endocrinology, Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turid","family":"Aas","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Hessman","sequence":"additional","affiliation":[{"name":"Department of Surgery V\u00e4stmanland County Hospital V\u00e4ster\u00e5s Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thord","family":"Ros\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rgen","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Institute of Clinical Sciences Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-884X","authenticated-orcid":false,"given":"Ansgar","family":"Heck","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Oslo Oslo Norway"},{"name":"Section of Specialized Endocrinology Oslo University Hospital Oslo 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