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Although some of their biological characteristics are documented in vitro, their role in diseases of the musculoskeletal system remains yet to be fully evaluated. In this review, we provide an overview of the role of COP cells in a number of physiological and pathological conditions, as well as identify areas for future research. In addition, we suggest possible areas for clinical utilization in the management of musculoskeletal diseases. \u00a9 2020 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4204","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T12:15:20Z","timestamp":1603973720000},"page":"12-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bone From Blood: Characteristics and Clinical Implications of Circulating Osteogenic Progenitor (COP) Cells"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-1299","authenticated-orcid":false,"given":"Jack","family":"Feehan","sequence":"first","affiliation":[{"name":"Department of Medicine University of Melbourne\u2013Western Health Melbourne VIC Australia"},{"name":"Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health St Albans VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-0869","authenticated-orcid":false,"given":"Moustapha","family":"Kassem","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem) University of Copenhagen Copenhagen Denmark"},{"name":"Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology Odense University Hospital & University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"Pignolo","sequence":"additional","affiliation":[{"name":"Department of Medicine Mayo Clinic School of Medicine, Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8126-0637","authenticated-orcid":false,"given":"Gustavo","family":"Duque","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne\u2013Western Health Melbourne VIC Australia"},{"name":"Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health St Albans VIC Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"issue":"5","key":"2024012713534055100_jbmr4204-bib-0001","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1189\/jlb.0403170","article-title":"Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation","volume":"74","author":"Kuwana","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"5","key":"2024012713534055100_jbmr4204-bib-0002","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1083\/jcb.153.5.1133","article-title":"Circulating skeletal stem cells","volume":"153","author":"Kuznetsov","year":"2001","journal-title":"J Cell Biol"},{"key":"2024012713534055100_jbmr4204-bib-0003","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.ebiom.2018.11.051","article-title":"Circulating osteogenic precursor cells: building bone from blood","volume":"39","author":"Feehan","year":"2019","journal-title":"EBioMedicine"},{"issue":"4","key":"2024012713534055100_jbmr4204-bib-0004","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. 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