{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:27:21Z","timestamp":1787614041275,"version":"build-2736575974"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012164","name":"National High-tech R&D Program","doi-asserted-by":"publisher","award":["2015AA020304"],"award-info":[{"award-number":["2015AA020304"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672133"],"award-info":[{"award-number":["81672133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874010"],"award-info":[{"award-number":["81874010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012164","name":"National High-tech Research and Development Program","doi-asserted-by":"publisher","award":["2015AA020304"],"award-info":[{"award-number":["2015AA020304"]}],"id":[{"id":"10.13039\/501100012164","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672133"],"award-info":[{"award-number":["81672133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874010"],"award-info":[{"award-number":["81874010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Systemic bone loss after initial fracture contributes to an increased risk of secondary fracture. Clinical research has revealed an association between the risk of future fracture and the number or magnitude of prior fractures. However, the change in systemic bone mass after single versus multiple fractures is unknown. We used ipsilateral femur and tibia fractures as multiple fractures and a femur or tibia fracture as a single fracture to investigate the influence of single versus multiple fractures on systemic bone mass. Seventy-two adult male C57BL\/6J mice underwent transverse osteotomies of the ipsilateral femur and\/or tibia with subsequent internal fixation. The dynamic change of in vivo whole-body BMD was assessed at 4\u2009days, 2\u2009weeks, and 4\u2009weeks after fracture. The microstructure of the L5 vertebral body and contralateral femur was assessed using micro-CT (\u03bcCT) and biomechanical tests (vertebral compression test and three-point bending test) at 2 and 4\u2009weeks. Tartrate-resistant acid phosphatase (TRAP) staining, sequential fluorescence labeling, and systemic inflammatory cytokines were also quantified. A greater decrease in whole-body BMD was observed after multiple than single fractures. The trabecular bone volume fraction, trabecular number, and trabecular thickness of the L5 vertebral body were significantly reduced. There were no significant differences in cortical thickness, trabecular bone microstructure, or bone strength in the contralateral femur. At 4\u2009days and 2\u2009weeks, we observed significant increases in the serum levels of IL-6 and TNF-\u03b1. We also observed an increase in the osteoclast number of the L5 vertebral body at 4\u2009days. These data indicate that systemic bone loss might increase with the number or severity of prior fractures, and the mechanism may be partly associated with an increased osteoclast number and a more severe inflammatory response. \u00a9 2020 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4211","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T17:35:46Z","timestamp":1605202546000},"page":"567-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice"],"prefix":"10.1093","volume":"36","author":[{"given":"Chenggui","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Jia","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-8998","authenticated-orcid":false,"given":"Zhiyuan","family":"Guan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantong","family":"Sun","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqiong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Leng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-9457","authenticated-orcid":false,"given":"Chunli","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Spinal Diseases Beijing China"},{"name":"Department of Orthopedics Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"issue":"4","key":"2024012713514062000_jbmr4211-bib-0001","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1359\/jbmr.2000.15.4.721","article-title":"Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis","volume":"15","author":"Klotzbuecher","year":"2000","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0002","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archinte.162.1.33","article-title":"Fractures between the ages of 20 and 50\u2009years increase women's risk of subsequent fractures","volume":"162","author":"Wu","year":"2002","journal-title":"Arch Intern Med"},{"issue":"10","key":"2024012713514062000_jbmr4211-bib-0003","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.2106\/00004623-200310000-00011","article-title":"Colles fracture, spine fracture, and subsequent risk of hip fracture in men and women. A meta-analysis","volume":"85","author":"Haentjens","year":"2003","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"2024012713514062000_jbmr4211-bib-0004","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF01623274","article-title":"Radial and humeral fractures as predictors of subsequent hip, radial or humeral fractures in women, and their seasonal variation","volume":"3","author":"Lauritzen","year":"1993","journal-title":"Osteoporos Int"},{"issue":"9","key":"2024012713514062000_jbmr4211-bib-0005","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2106\/00004623-200209000-00004","article-title":"Refractures in patients at least forty-five years old. A prospective analysis of twenty-two thousand and sixty patients","volume":"84","author":"Robinson","year":"2002","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"2024012713514062000_jbmr4211-bib-0006","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2106\/JBJS.G.01529","article-title":"Proximal humeral fracture as a risk factor for subsequent hip fractures","volume":"91","author":"Clinton","year":"2009","journal-title":"J Bone Joint Surg Am"},{"issue":"3","key":"2024012713514062000_jbmr4211-bib-0007","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00198-003-1514-0","article-title":"Fracture risk following an osteoporotic fracture","volume":"15","author":"Johnell","year":"2004","journal-title":"Osteoporos Int"},{"issue":"5","key":"2024012713514062000_jbmr4211-bib-0008","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1359\/jbmr.1999.14.5.821","article-title":"Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group","volume":"14","author":"Black","year":"1999","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2024012713514062000_jbmr4211-bib-0009","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00198-017-3976-5","article-title":"Imminent fracture risk","volume":"28","author":"Roux","year":"2017","journal-title":"Osteoporos Int"},{"issue":"3","key":"2024012713514062000_jbmr4211-bib-0010","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00198-016-3868-0","article-title":"Imminent risk of fracture after fracture","volume":"28","author":"Johansson","year":"2017","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jbmr.3579","article-title":"Age dependence of systemic bone loss and recovery following femur fracture in mice","volume":"34","author":"Emami","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024012713514062000_jbmr4211-bib-0012","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1302\/0301-620X.60B4.711798","article-title":"Ipsilateral fracture of the femur and tibia","volume":"60-b","author":"Fraser","year":"1978","journal-title":"J Bone Joint Surg Br"},{"issue":"9651","key":"2024012713514062000_jbmr4211-bib-0013","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/S0140-6736(08)61367-7","article-title":"Injury-related fatalities in China: an under-recognised public-health problem","volume":"372","author":"Wang","year":"2008","journal-title":"Lancet"},{"issue":"10197","key":"2024012713514062000_jbmr4211-bib-0014","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(19)31632-0","article-title":"Road safety in Sudan","volume":"394","author":"Sokourenko","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"2024012713514062000_jbmr4211-bib-0015","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00198-019-05274-2","article-title":"Fracture risk following high-trauma versus low-trauma fracture: a registry-based cohort study","volume":"31","author":"Leslie","year":"2020","journal-title":"Osteoporos Int"},{"key":"2024012713514062000_jbmr4211-bib-0016","doi-asserted-by":"crossref","first-page":"890816","DOI":"10.1155\/2012\/890816","article-title":"A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response","volume":"2012","author":"Weckbach","year":"2012","journal-title":"Mediators Inflamm"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0017","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1563\/AAID-JOI-D-09-00090","article-title":"Effect of dehiscences to the bone response of implants with an acid-etched surface: an experimental study in miniature pigs","volume":"37","author":"Ruehe","year":"2011","journal-title":"J Oral Implantol"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0018","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11657-016-0280-5","article-title":"Predicting imminent risk for fracture in patients aged 50 or older with osteoporosis using US claims data","volume":"11","author":"Bonafede","year":"2016","journal-title":"Arch Osteoporos"},{"issue":"4","key":"2024012713514062000_jbmr4211-bib-0019","first-page":"461","article-title":"Prevalence and cost of subsequent fractures among U.S. patients with an incident fracture","volume":"23","author":"Weaver","year":"2017","journal-title":"J Manag Care Spec Pharm"},{"issue":"11","key":"2024012713514062000_jbmr4211-bib-0020","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3928\/0147-7447-19961101-08","article-title":"Measurement of bone mineral density in osteoporotic fractures of the spine using dual energy X-ray absorptiometry","volume":"19","author":"Jahng","year":"1996","journal-title":"Orthopedics"},{"issue":"10","key":"2024012713514062000_jbmr4211-bib-0021","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1007\/s00198-018-4606-6","article-title":"Incident fracture is associated with a period of accelerated loss of hip BMD: the Study of Osteoporotic Fractures","volume":"29","author":"Christiansen","year":"2018","journal-title":"Osteoporos Int"},{"key":"2024012713514062000_jbmr4211-bib-0022","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","article-title":"Animal models for osteoporosis","volume":"759","author":"Komori","year":"2015","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"2024012713514062000_jbmr4211-bib-0023","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/jbmr.5650060412","article-title":"A systemic acceleratory phenomenon (SAP) accompanies the regional acceleratory phenomenon (RAP) during healing of a bone defect in the rat","volume":"6","author":"Mueller","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024012713514062000_jbmr4211-bib-0024","first-page":"1233","article-title":"Morphologic and molecular alteration during tibia fracture healing in rat","volume":"22","author":"Yu","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrrheum.2014.164","article-title":"Fracture healing: mechanisms and interventions","volume":"11","author":"Einhorn","year":"2015","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"2024012713514062000_jbmr4211-bib-0026","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00402-008-0632-8","article-title":"Changes in serum levels of receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, IL-6 and TNF-alpha in patients with a concomitant head injury and fracture","volume":"129","author":"Lee","year":"2009","journal-title":"Arch Orthop Trauma Surg"},{"issue":"3","key":"2024012713514062000_jbmr4211-bib-0027","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jocd.2010.04.003","article-title":"Contribution of serum inflammatory markers to changes in bone mineral content and density in postmenopausal women: a 1-year investigation","volume":"13","author":"Gertz","year":"2010","journal-title":"J Clin Densitom"},{"issue":"5","key":"2024012713514062000_jbmr4211-bib-0028","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1210\/jc.2007-2325","article-title":"Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study","volume":"93","author":"Ding","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2024012713514062000_jbmr4211-bib-0029","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1002\/art.22117","article-title":"Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis","volume":"54","author":"van Staa","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"2","key":"2024012713514062000_jbmr4211-bib-0030","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00068-002-1183-2","article-title":"Interleukin-6 (IL-6) \u2013 an early marker of chest trauma","volume":"28","author":"Strecker","year":"2002","journal-title":"Eur J Trauma"},{"issue":"9","key":"2024012713514062000_jbmr4211-bib-0031","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1007\/s11999-013-2908-8","article-title":"Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study","volume":"471","author":"Pfeifer","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0032","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2249.1991.tb05694.x","article-title":"Selective and early increase of IL-1 inhibitors, IL-6 and cortisol after elective surgery","volume":"85","author":"Di Padova","year":"1991","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0033","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/SHK.0b013e31815d190b","article-title":"Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture","volume":"30","author":"Kobbe","year":"2008","journal-title":"Shock"},{"issue":"11","key":"2024012713514062000_jbmr4211-bib-0034","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1097\/00003246-199711000-00018","article-title":"Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma","volume":"25","author":"Martin","year":"1997","journal-title":"Crit Care Med"},{"issue":"4","key":"2024012713514062000_jbmr4211-bib-0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/CS20110340","article-title":"IL-6\/IL-6 receptor system and its role in physiological and pathological conditions","volume":"122","author":"Mihara","year":"2012","journal-title":"Clin Sci (London)"},{"key":"2024012713514062000_jbmr4211-bib-0036","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bone.2018.04.015","article-title":"IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy","volume":"112","author":"Lazzaro","year":"2018","journal-title":"Bone"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0037","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/art.38218","article-title":"Combination of tumor necrosis factor \u03b1 and interleukin-6 induces mouse osteoclast-like cells with bone resorption activity both in vitro and in vivo","volume":"66","author":"Yokota","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"2024012713514062000_jbmr4211-bib-0038","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1038\/s41598-017-07511-2","article-title":"Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice","volume":"7","author":"Fischer","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"2024012713514062000_jbmr4211-bib-0039","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/jor.21180","article-title":"Effects of calcium supplements on fracture healing in a rat osteoporotic model","volume":"28","author":"Shuid","year":"2010","journal-title":"J Orthop Res"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/3\/567\/55457751\/jbmr4211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/3\/567\/55457751\/jbmr4211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:06:23Z","timestamp":1710327983000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/36\/3\/567-578\/7516688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,11,12]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4211","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4211\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4211\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4211\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4211\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4211\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4211\/v2\/response1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,11,12]]},"assertion":[{"value":"2020-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}