{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:18:17Z","timestamp":1791011897342,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T00:00:00Z","timestamp":1305504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic kidney disease (CKD) is associated with increased fracture risk and skeletal deformities. The impact of CKD on volumetric bone mineral density (vBMD) and cortical dimensions during growth is unknown. Tibia quantitative computed tomographic scans were obtained in 156 children with CKD [69 stages 2 to 3, 51 stages 4 to 5, and 36 stage 5D (dialysis)] and 831 healthy participants aged 5 to 21 years. Sex-, race-, and age- or tibia length\u2013specific Z-scores were generated for trabecular BMD (TrabBMD), cortical BMD (CortBMD), cortical area (CortArea) and endosteal circumference (EndoC). Greater CKD severity was associated with a higher TrabBMD Z-score in younger participants (p\u2009&amp;lt;\u2009.001) compared with healthy children; this association was attenuated in older participants (interaction p\u2009&amp;lt;\u2009.001). Mean CortArea Z-score was lower (p\u2009&amp;lt;\u2009.01) in CKD 4\u20135 [\u22120.49, 95% confidence interval (CI) \u22120.80, \u22120.18)] and CKD 5D (\u22120.49, 95% CI \u22120.83, \u22120.15) compared with healthy children. Among CKD participants, parathyroid hormone (PTH) levels were positively associated with TrabBMD Z-score (p\u2009&amp;lt;\u2009.01), and this association was significantly attenuated in older participants (interaction p\u2009&amp;lt;\u2009.05). Higher levels of PTH and biomarkers of bone formation (bone-specific alkaline phosphatase) and resorption (serum C-terminal telopeptide of type 1 collagen) were associated with lower CortBMD and CortArea Z-scores and greater EndoC Z-score (r\u2009=\u20090.18\u20130.36, all p\u2009\u2264\u2009.02). CortBMD Z-score was significantly lower in CKD participants with PTH levels above versus below the upper limit of the Kidney Disease Outcome Quality Initiative (KDOQI) CKD stage-specific target range: \u22120.46\u2009\u00b1\u20091.29 versus 0.12\u2009\u00b1\u20091.14 (p\u2009&amp;lt;\u2009.01). In summary, childhood CKD and secondary hyperparathyroidism were associated with significant reductions in cortical area and CortBMD and greater TrabBMD in younger children. Future studies are needed to establish the fracture implications of these alterations and to determine if cortical and trabecular abnormalities are reversible. \u00a9 2011 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.427","type":"journal-article","created":{"date-parts":[[2011,5,16]],"date-time":"2011-05-16T16:20:12Z","timestamp":1305562812000},"page":"2235-2244","source":"Crossref","is-referenced-by-count":53,"title":["Volumetric bone mineral density and bone structure in childhood chronic kidney disease"],"prefix":"10.1093","volume":"26","author":[{"given":"Rachel J","family":"Wetzsteon","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi J","family":"Kalkwarf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Shults","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette S","family":"Zemel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany J","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, McGill University School of Medicine, Montreal, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Frederic","family":"Strife","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie L","family":"Foerster","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlene K","family":"Jean-Pierre","sequence":"additional","affiliation":[{"name":"Department of Surgery, Albert Einstein College of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA"},{"name":"Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,5,16]]},"reference":[{"key":"2024020317591439300_bib1","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1210\/jc.2009-1913","article-title":"Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults","volume":"95","author":"Leonard","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020317591439300_bib2","first-page":"1420","article-title":"Differential effect of race on the axial and appendicular skeletons of children","volume":"83","author":"Gilsanz","year":"1998","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020317591439300_bib3","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","article-title":"Increased risk of hip fracture among patients with end-stage renal disease","volume":"58","author":"Alem","year":"2000","journal-title":"Kidney Int."},{"key":"2024020317591439300_bib4","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1001\/jama.288.23.3014","article-title":"Risk of hip fracture among dialysis and renal transplant recipients","volume":"288","author":"Ball","year":"2002","journal-title":"JAMA."},{"key":"2024020317591439300_bib5","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1681\/ASN.2005111194","article-title":"Relationship between moderate to severe kidney disease and hip fracture in the united states","volume":"17","author":"Nickolas","year":"2006","journal-title":"J Am Soc Nephrol."},{"key":"2024020317591439300_bib6","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1002\/jbmr.309","article-title":"Renal osteodystrophy in the first decade of the new millennium-analysis of 630 bone biopsies in black and white patients","volume":"26","author":"Malluche","year":"2011","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib7","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1681\/ASN.V971225","article-title":"Mineralized bone loss at different sites in dialysis patients: implications for prevention","volume":"9","author":"Schober","year":"1998","journal-title":"J Am Soc Nephrol."},{"key":"2024020317591439300_bib8","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1359\/jbmr.1998.13.8.1213","article-title":"A structural approach to renal bone disease","volume":"13","author":"Parfitt","year":"1998","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib9","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1210\/jc.2009-2057","article-title":"Height adjustment in assessing dual energy x-ray absorptiometry measurements of bone mass and density in children","volume":"95","author":"Zemel","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"key":"2024020317591439300_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1034\/j.1600-6143.2001.001003243.x","article-title":"The prevalence of osteopenia in pediatric renal allograft recipients varies with the method of analysis","volume":"1","author":"Saland","year":"2001","journal-title":"Am J Transplant."},{"key":"2024020317591439300_bib11","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00467-007-0546-7","article-title":"Bone mineral density and bone histomorphometry in children on long-term dialysis","volume":"22","author":"Andrade","year":"2007","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s001980200039","article-title":"Skeletal status in children, adolescents and young adults with end-stage renal failure treated with hemo- or peritoneal dialysis","volume":"13","author":"Pluskiewicz","year":"2002","journal-title":"Osteoporos Int."},{"key":"2024020317591439300_bib13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00198-002-1335-6","article-title":"Skeletal status in children and adolescents with chronic renal failure before onset of dialysis or on dialysis","volume":"14","author":"Pluskiewicz","year":"2003","journal-title":"Osteoporos Int."},{"key":"2024020317591439300_bib14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00198-004-1672-8","article-title":"Skeletal status in adolescents with end-stage renal failure: a longitudinal study","volume":"16","author":"Pluskiewicz","year":"2005","journal-title":"Osteoporos Int."},{"key":"2024020317591439300_bib15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1046\/j.1365-2265.1998.00593.x","article-title":"Bone mineral density, bone metabolism and body composition of children with chronic renal failure, with and without growth hormone treatment","volume":"49","author":"Boot","year":"1998","journal-title":"Clin Endocrinol (Oxf)."},{"key":"2024020317591439300_bib16","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s00467-004-1670-2","article-title":"Bone mineral density and bone turnover markers in children with chronic renal failure","volume":"19","author":"Bakr","year":"2004","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00467-006-0292-2","article-title":"Bone mineral density in children with chronic renal failure","volume":"22","author":"Waller","year":"2007","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib18","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1007\/s00467-005-1973-y","article-title":"Bone mineral content, corrected for height or bone area, measured by dxa is not reduced in children with chronic renal disease or in hypoparathyroidism","volume":"20","author":"Ahmed","year":"2005","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s004310100734","article-title":"Growth hormone treatment enhances bone mineralisation in children with chronic renal failure","volume":"160","author":"Van dyck","year":"2001","journal-title":"Eur J Pediatr."},{"key":"2024020317591439300_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s004670000470","article-title":"Bone density and body composition in chronic renal failure: effects of growth hormone treatment","volume":"15","author":"Van der Sluis","year":"2000","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1651-2227.2008.01073.x","article-title":"Children with chronic kidney disease: a 3-year prospective study of growth, bone mass and bone turnover","volume":"98","author":"Swolin-eide","year":"2009","journal-title":"Acta Paediatr."},{"key":"2024020317591439300_bib22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1651-2227.2007.00236.x","article-title":"Bone mass, biochemical markers and growth in children with chronic kidney disease: a 1-year prospective study","volume":"96","author":"Swolin-eide","year":"2007","journal-title":"Acta Paediatr."},{"key":"2024020317591439300_bib23","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1359\/jbmr.060105","article-title":"Cortical pqct measures are associated with fractures in dialysis patients","volume":"21","author":"Jamal","year":"2006","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib24","first-page":"24","article-title":"Bone mineral density in pediatric patients after renal transplantation","volume":"46","author":"Behnke","year":"1996","journal-title":"Clin Nephrol."},{"key":"2024020317591439300_bib25","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1093\/ndt\/16.11.2236","article-title":"Bone mineral density in children with primary hyperoxaluria type i","volume":"16","author":"Behnke","year":"2001","journal-title":"Nephrol Dial Transplant."},{"key":"2024020317591439300_bib26","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/s00467-002-1041-9","article-title":"Bone density measurements in pediatric patients with renal osteodystrophy","volume":"18","author":"Lima","year":"2003","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib27","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1111\/j.1523-1755.2004.00937.x","article-title":"Analysis of the functional muscle-bone unit of the forearm in pediatric renal transplant recipients","volume":"66","author":"Ruth","year":"2004","journal-title":"Kidney Int."},{"key":"2024020317591439300_bib28","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s004670000360","article-title":"Analysis of muscle strength and bone structure in children with renal disease","volume":"14","author":"Tenbrock","year":"2000","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib29","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00467-010-1745-1","article-title":"Bone assessment in children with chronic kidney disease: data from two new bone imaging techniques in a single-center pilot study","volume":"26","author":"Bacchetta","year":"2011","journal-title":"Pediatr Nephrol."},{"key":"2024020317591439300_bib30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1681\/ASN.2010060603","article-title":"Association of chronic kidney disease with muscle deficits in children","volume":"22","author":"Foster","journal-title":"J Am Soc Nephrol."},{"key":"2024020317591439300_bib31","volume-title":"Assessment of skeletal maturity and prediction of adult height (tw2 method)","author":"Tanner","year":"1975"},{"key":"2024020317591439300_bib32","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02088471","article-title":"Validation of a self-administered instrument to assess stage of adolescent development","volume":"9","author":"Morris","year":"1980","journal-title":"J Youth Adolesc."},{"key":"2024020317591439300_bib33","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1385\/JCD:3:1:009","article-title":"Pqct measurement of bone parameters in young children: validation of technique","volume":"3","author":"Binkley","year":"2000","journal-title":"J Clin Densitom."},{"key":"2024020317591439300_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate gfr in children with ckd","volume":"20","author":"Schwartz","year":"2009","journal-title":"J Am Soc Nephrol."},{"key":"2024020317591439300_bib35"},{"key":"2024020317591439300_bib36","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.2001.16.4.605","article-title":"Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function","volume":"16","author":"Gao","year":"2001","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1542\/peds.109.1.45","article-title":"Centers for disease control and prevention 2000 Growth charts for the united states: improvements to the 1977 National center for health statistics version","volume":"109","author":"Ogden","year":"2002","journal-title":"Pediatrics."},{"key":"2024020317591439300_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.gastro.2008.09.072","article-title":"Longitudinal assessment of bone density and structure in an incident cohort of children with crohn's disease","volume":"136","author":"Dubner","year":"2009","journal-title":"Gastroenterology."},{"key":"2024020317591439300_bib39","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1359\/jbmr.081101","article-title":"Divergent effects of glucocorticoids on cortical and trabecular compartment bmd in childhood nephrotic syndrome","volume":"24","author":"Wetzsteon","year":"2009","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib40","first-page":"45","article-title":"The lms method for constructing normalized growth standards","volume":"44","author":"Cole","year":"1990","journal-title":"Eur J Clin Nutr."},{"key":"2024020317591439300_bib41","author":"Pan","year":"2010"},{"key":"2024020317591439300_bib42","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00031305.2000.10474549","article-title":"Using heteroscedasticity-consistent standard errors in the linear regression model","volume":"54","author":"Long","year":"2000","journal-title":"Am Stat."},{"key":"2024020317591439300_bib43","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jpeds.2008.04.028","article-title":"Interpretation of biomarkers of bone metabolism in children: impact of growth velocity and body size in healthy children and chronic disease","volume":"153","author":"Tuchman","year":"2008","journal-title":"J Pediatr."},{"key":"2024020317591439300_bib44"},{"key":"2024020317591439300_bib45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF00974065","article-title":"Roentgenological signs in the skeleton of uremic children. An analysis of the anatomical principles underlying the roentgenological changes","volume":"1","author":"Mehls","year":"1973","journal-title":"Pediatr Radiol."},{"key":"2024020317591439300_bib46","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/art.23683","article-title":"Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits","volume":"58","author":"Burnham","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2024020317591439300_bib47","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00198-007-0394-0","article-title":"Glucocorticoid-induced osteoporosis: pathophysiology and therapy","volume":"18","author":"Canalis","year":"2007","journal-title":"Osteoporos Int."},{"key":"2024020317591439300_bib48","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.micron.2005.07.009","article-title":"Histomorphometric analysis of glucocorticoid-induced osteoporosis","volume":"36","author":"Dalle Carbonare","year":"2005","journal-title":"Micron."},{"key":"2024020317591439300_bib49","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1359\/jbmr.090831","article-title":"Early impairment of trabecular microarchitecture assessed with hr-pqct in patients with stage ii-iv chronic kidney disease","volume":"25","author":"Bacchetta","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib50","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/01.ASN.0000039565.56011.BE","article-title":"Effects of thyroparathyroidectomy, exogenous calcium, and short-term calcitriol therapy on the growth plate in renal failure","volume":"14","author":"Sanchez","year":"2003","journal-title":"J Am Soc Nephrol."},{"key":"2024020317591439300_bib51","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1111\/j.1523-1755.2004.00577.x","article-title":"Bone elongation in rats with renal failure and mild or advanced secondary hyperparathyroidism","volume":"65","author":"Sanchez","year":"2004","journal-title":"Kidney Int."},{"key":"2024020317591439300_bib52","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1359\/jbmr.2001.16.4.597","article-title":"Changes in bone density during childhood and adolescence: an approach based on bone's biological organization","volume":"16","author":"Rauch","year":"2001","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib53","first-page":"329","article-title":"Metacarpal cortical dimensions in hypoparathyroidism, primary hyperparathyroidism and chronic renal failure","author":"Parfitt","year":"1977","journal-title":"Calcif Tissue Res."},{"key":"2024020317591439300_bib54","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/01.rct.0000238007.19258.3d","article-title":"Quantitative microcomputed tomography assessment of intratrabecular, intertrabecular, and cortical bone architecture in a rat model of severe renal osteodystrophy","volume":"31","author":"Hopper","year":"2007","journal-title":"J Comput Assist Tomogr."},{"key":"2024020317591439300_bib55","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s001980050089","article-title":"Volumetric bone density and geometry assessed by peripheral quantitative computed tomography in uremic patients on maintenance hemodialysis","volume":"8","author":"Russo","year":"1998","journal-title":"Osteoporos Int."},{"key":"2024020317591439300_bib56","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9290(03)00174-X","article-title":"Estimation of bone mineral density and architectural parameters of the distal radius in hemodialysis patients using peripheral quantitative computed tomography","volume":"37","author":"Hasegawa","year":"2004","journal-title":"J Biomech."},{"key":"2024020317591439300_bib57","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1542-4758.2006.00128.x","article-title":"Evaluation of cortical bone by peripheral quantitative computed tomography in continuous ambulatory peritoneal dialysis patients","volume":"10","author":"Negri","year":"2006","journal-title":"Hemodial Int."},{"key":"2024020317591439300_bib58","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bone.2007.08.044","article-title":"Extracellular acidification enhances osteoclast survival through an nfat-independent, protein kinase c-dependent pathway","volume":"42","author":"Pereverzev","year":"2008","journal-title":"Bone."},{"key":"2024020317591439300_bib59","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1359\/jbmr.2002.17.6.1095","article-title":"Bone mineral content per muscle cross-sectional area as an index of the functional muscle-bone unit","volume":"17","author":"Schoenau","year":"2002","journal-title":"J Bone Miner Res."},{"key":"2024020317591439300_bib60","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1172\/JCI117244","article-title":"Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation","volume":"93","author":"Roubenoff","year":"1994","journal-title":"J Clin Invest."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.427","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/9\/2235\/56558720\/427_ftp.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/26\/9\/2235\/56558720\/427_ftp.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T19:00:41Z","timestamp":1712430041000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/26\/9\/2235-2244\/7598067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,16]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2011,5,16]]},"published-print":{"date-parts":[[2011,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.427","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,9,1]]},"published":{"date-parts":[[2011,5,16]]}}}