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The majority are caused by the ubiquitous bacterium Staphyloccocus (S.) aureus, which can exist as a commensal organism on human skin as well as an invasive pathogen, but a multitude of other microbes are also capable of establishing bone infections. While studies of clinical isolates and small animal models have advanced our understanding of the role of various pathogen and host factors in infectious osteomyelitis (iOM), many questions remain unaddressed. Thus, there are many opportunities to elucidate host-pathogen interactions that may be leveraged toward treatment or prevention of this troublesome problem. Herein, we combine perspectives from bone biology and microbiology and suggest that interdisciplinary approaches will bring new insights to the field. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4279","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T15:06:03Z","timestamp":1616166363000},"page":"636-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Infectious Osteomyelitis: Marrying Bone Biology and Microbiology to Shed New Light on a Persistent Clinical Challenge"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-5582","authenticated-orcid":false,"given":"Deborah J","family":"Veis","sequence":"first","affiliation":[{"name":"Shriners Hospitals for Children St. Louis MO USA"},{"name":"Musculoskeletal Research Center Washington University School of Medicine St. Louis MO USA"},{"name":"Department of Pathology and Immunology Washington University School of Medicine St. Louis MO USA"},{"name":"Division of Bone and Mineral Diseases Departments of Medicine and Pathology, Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-1167","authenticated-orcid":false,"given":"James E","family":"Cassat","sequence":"additional","affiliation":[{"name":"Vanderbilt Center for Bone Biology Vanderbilt University Medical Center Nashville TN USA"},{"name":"Vanderbilt Institute for Infection, Immunology and Inflammation (VI4) Vanderbilt University Medical Center Nashville TN USA"},{"name":"Department of Biomedical Engineering Vanderbilt University Nashville TN USA"},{"name":"Department of Pediatrics, Division of Pediatric Infectious Diseases Vanderbilt University Medical Center Nashville TN USA"},{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center Nashville, TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"issue":"4","key":"2026041420274596300_jbmr4279-bib-0001","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.mporth.2015.02.002","article-title":"(iii) Osteomyelitis\u2014a historical and basic sciences review","volume":"29","author":"Radcliffe","year":"2015","journal-title":"Orthop Trauma."},{"issue":"5","key":"2026041420274596300_jbmr4279-bib-0002","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jor.24293","article-title":"2018 international consensus meeting on musculoskeletal infection: research priorities from the general assembly questions","volume":"37","author":"Schwarz","year":"2019","journal-title":"J Orthop 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