{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:11:21Z","timestamp":1788991881748,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T00:00:00Z","timestamp":1617494400000},"content-version":"vor","delay-in-days":124,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FRQS Programme de bourses de chercheur"},{"DOI":"10.13039\/501100022502","name":"Mereo BioPharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100022502","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF Ambizione grant #174192"],"award-info":[{"award-number":["SNF Ambizione grant #174192"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF grant #165510"],"award-info":[{"award-number":["SNF grant #165510"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SFA PHRT IDoc","award":["grant #2017-304"],"award-info":[{"award-number":["grant #2017-304"]}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF Ambizione grant #174192"],"award-info":[{"award-number":["SNF Ambizione grant #174192"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF grant #165510"],"award-info":[{"award-number":["SNF grant #165510"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011781","name":"Shriners Hospitals for Children","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteogenesis imperfecta (OI) is an inheritable, genetic, and collagen-related disorder leading to an increase in bone fragility, but the origin of its \u201cbrittle behavior\u201d is unclear. Because of its complex hierarchical structure, bone behaves differently at various length scales. This study aims to compare mechanical properties of human OI bone with healthy control bone at the extracellular matrix (ECM) level and to quantify the influence of the degree of mineralization. Degree of mineralization and mechanical properties were analyzed under dry conditions in 12 fixed and embedded transiliac crest biopsies (control n\u00a0=\u00a06, OI type I n\u00a0=\u00a03, OI type IV n\u00a0=\u00a02, and OI type III n\u00a0=\u00a01). Mean degree of mineralization was measured by microcomputed tomography at the biopsy level and the mineral-to-matrix ratio was assessed by Raman spectroscopy at the ECM level. Both methods revealed that the degree of mineralization is higher for OI bone compared with healthy control. Micropillar compression is a novel technique for quantifying post-yield properties of bone at the ECM level. Micropillars (d\u00a0=\u00a05\u2009\u03bcm, h\u00a0=\u00a010\u2009\u03bcm) were fabricated using focused ion beam milling and quasi-statically compressed to capture key post-yield properties such as ultimate strength. The qualitative inspection of the stress\u2013strain curves showed that both OI and healthy control bone have a ductile response at the ECM level. The quantitative results showed that compressive strength is not reduced in OI bone and is increasing with OI severity. Nanoindentation measurements revealed that OI bone tends to have a higher Young's modulus, hardness, and dissipated energy compared with healthy bone. Micropillar strength and indentation modulus increased linearly and significantly (p\u2009&amp;lt;\u2009.0001) with mineral-to-matrix ratio. In conclusion, this study indicates that compressive mechanical properties of dry OI bone at the iliac crest are not inferior to healthy control at the ECM level and increase with mineralization. \u00a9 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4286","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T14:21:53Z","timestamp":1616163713000},"page":"1364-1375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Compressive Strength of Iliac Bone ECM Is Not Reduced in Osteogenesis Imperfecta and Increases With Mineralization"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-4184","authenticated-orcid":false,"given":"Michael","family":"Indermaur","sequence":"first","affiliation":[{"name":"ARTORG Center for Biomedical Engineering Research University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-5070","authenticated-orcid":false,"given":"Daniele","family":"Casari","sequence":"additional","affiliation":[{"name":"Swiss Federal Laboratories for Material Science and Technology, Empa Thun Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kochetkova","sequence":"additional","affiliation":[{"name":"Swiss Federal Laboratories for Material Science and Technology, Empa Thun Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0720-4252","authenticated-orcid":false,"given":"Cinzia","family":"Peruzzi","sequence":"additional","affiliation":[{"name":"Swiss Federal Laboratories for Material Science and Technology, Empa Thun Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-3372","authenticated-orcid":false,"given":"Elizabeth","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"McGill University Montreal Canada"},{"name":"Shriners Hospital for Children Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-0360","authenticated-orcid":false,"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"McGill University Montreal Canada"},{"name":"Shriners Hospital for Children Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2907-3580","authenticated-orcid":false,"given":"Bettina","family":"Willie","sequence":"additional","affiliation":[{"name":"McGill University Montreal Canada"},{"name":"Shriners Hospital for Children Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-4068","authenticated-orcid":false,"given":"Johann","family":"Michler","sequence":"additional","affiliation":[{"name":"Swiss Federal Laboratories for Material Science and Technology, Empa Thun Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-2828","authenticated-orcid":false,"given":"Jakob","family":"Schwiedrzik","sequence":"additional","affiliation":[{"name":"Swiss Federal Laboratories for Material Science and Technology, Empa Thun Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4712-7047","authenticated-orcid":false,"given":"Philippe","family":"Zysset","sequence":"additional","affiliation":[{"name":"ARTORG Center for Biomedical Engineering Research University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"issue":"12","key":"2024012713473913500_jbmr4286-bib-0001","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1002\/ajmg.a.61366","article-title":"Nosology and classification of genetic skeletal disorders: 2019 revision","volume":"179","author":"Mortier","year":"2019","journal-title":"Am J Med Genet A."},{"issue":"1","key":"2024012713473913500_jbmr4286-bib-0002","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jbmr.2920","article-title":"Fracture rates and fracture sites in patients with osteogenesis imperfecta: a nationwide register-based cohort study","volume":"32","author":"Folkestad","year":"2017","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024012713473913500_jbmr4286-bib-0003","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1007\/s00198-015-3156-4","article-title":"Bone structure assessed by HR-pQCT, TBS and DXL in adult patients with different types of osteogenesis imperfecta","volume":"26","author":"Kocijan","year":"2015","journal-title":"Osteoporos Int."},{"issue":"6","key":"2024012713473913500_jbmr4286-bib-0004","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/jbmr.1592","article-title":"Bone geometry, density, and microarchitecture in the distal radius and tibia in adults with osteogenesis imperfecta type I assessed by high-resolution pQCT","volume":"27","author":"Folkestad","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024012713473913500_jbmr4286-bib-0005","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S8756-3282(00)00269-6","article-title":"Static and dynamic bone histomorphometry in children with osteogenesis imperfecta","volume":"26","author":"Rauch","year":"2000","journal-title":"Bone."},{"key":"2024012713473913500_jbmr4286-bib-0006","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jmbbm.2014.12.020","article-title":"Microstructure and compressive mechanical properties of cortical bone in children with osteogenesis imperfecta treated with bisphosphonates compared with healthy children","volume":"46","author":"Imbert","year":"2015","journal-title":"J Mech Behav Biomed Mater."},{"key":"2024012713473913500_jbmr4286-bib-0007","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bone.2014.04.030","article-title":"Mechanical and mineral properties of osteogenesis imperfecta human bones at the tissue level","volume":"65","author":"Imbert","year":"2014","journal-title":"Bone"},{"issue":"3","key":"2024012713473913500_jbmr4286-bib-0008","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bone.2006.02.071","article-title":"Pamidronate does not adversely affect bone intrinsic material properties in children with osteogenesis imperfecta","volume":"39","author":"Weber","year":"2006","journal-title":"Bone."},{"issue":"4","key":"2024012713473913500_jbmr4286-bib-0009","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00223-008-9113-x","article-title":"Evidence that abnormal high bone mineralization in growing children with osteogenesis imperfecta is not associated with specific collagen mutations","volume":"82","author":"Roschger","year":"2008","journal-title":"Calcif Tissue Int."},{"key":"2024012713473913500_jbmr4286-bib-0010","first-page":"1","article-title":"Bisphosphonate therapy for osteogenesis imperfecta (review)","volume":"7","author":"Dwan","year":"2016","journal-title":"Cochrane Libr."},{"issue":"2","key":"2024012713473913500_jbmr4286-bib-0011","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1359\/JBMR.051015","article-title":"Effects of oral alendronate on BMD in adult patients with osteogenesis imperfecta: a 3-year randomized placebo-controlled trial","volume":"21","author":"Chevrel","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"14","key":"2024012713473913500_jbmr4286-bib-0012","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1056\/NEJM199810013391402","article-title":"Cyclic administration of pamidronate therapy in children with severe osteogenesis imperfecta","volume":"339","author":"Glorieux","year":"1998","journal-title":"N Engl J Med."},{"issue":"4","key":"2024012713473913500_jbmr4286-bib-0013","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1359\/jbmr.2003.18.4.610","article-title":"Bone mass, size, and density in children and adolescents with osteogenesis imperfecta: effect of intravenous pamidronate therapy","volume":"18","author":"Rauch","year":"2003","journal-title":"J Bone Miner Res."},{"issue":"9418","key":"2024012713473913500_jbmr4286-bib-0014","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(04)16051-0","article-title":"Osteogenesis imperfecta","volume":"363","author":"Rauch","year":"2004","journal-title":"Lancet."},{"issue":"6","key":"2024012713473913500_jbmr4286-bib-0015","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1557\/JMR.1992.1564","article-title":"An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments","volume":"7","author":"Oliver","year":"1992","journal-title":"J Mater Res."},{"issue":"10","key":"2024012713473913500_jbmr4286-bib-0016","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0021-9290(99)00111-6","article-title":"Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur","volume":"32","author":"Zysset","year":"1999","journal-title":"J Biomech."},{"issue":"6","key":"2024012713473913500_jbmr4286-bib-0017","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00198-009-0854-9","article-title":"Indentation of bone tissue: a short review","volume":"20","author":"Zysset","year":"2009","journal-title":"Osteoporos Int."},{"issue":"2","key":"2024012713473913500_jbmr4286-bib-0018","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bone.2009.09.035","article-title":"Rehydration of vertebral trabecular bone: influences on its anisotropy, its stiffness and the indentation work with a view to age, gender and vertebral level","volume":"46","author":"Wolfram","year":"2010","journal-title":"Bone"},{"issue":"1","key":"2024012713473913500_jbmr4286-bib-0019","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clinbiomech.2012.10.003","article-title":"Bone properties by nanoindentation in mild and severe osteogenesis imperfecta","volume":"28","author":"Albert","year":"2013","journal-title":"Clin Biomech"},{"issue":"3","key":"2024012713473913500_jbmr4286-bib-0020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.compositesb.2006.08.006","article-title":"Nanoindentation as a means for distinguishing clinical type of osteogenesis imperfecta","volume":"38","author":"Fan","year":"2007","journal-title":"Compos B Eng."},{"issue":"5686","key":"2024012713473913500_jbmr4286-bib-0021","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.1098993","article-title":"Sample dimensions influence strength and crystal plasticity","volume":"305","author":"Uchic","year":"2004","journal-title":"Science."},{"issue":"1\u20132 Suppl","key":"2024012713473913500_jbmr4286-bib-0022","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.msea.2005.03.082","article-title":"A methodology to investigate size scale effects in crystalline plasticity using uniaxial compression testing","volume":"400\u20131","author":"Uchic","year":"2005","journal-title":"Mater Sci Eng A."},{"issue":"4","key":"2024012713473913500_jbmr4286-bib-0023","doi-asserted-by":"crossref","first-page":"043123","DOI":"10.1063\/1.2432277","article-title":"Plastic deformation of gallium arsenide micropillars under uniaxial compression at room temperature","volume":"90","author":"Michler","year":"2007","journal-title":"Appl Phys Lett."},{"issue":"7","key":"2024012713473913500_jbmr4286-bib-0024","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nmat3959","article-title":"In situ micropillar compression reveals superior strength and ductility but an absence of damage in lamellar bone","volume":"13","author":"Schwiedrzik","year":"2014","journal-title":"Nat Mater."},{"key":"2024012713473913500_jbmr4286-bib-0025","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.actbio.2017.07.030","article-title":"Nanoscale deformation mechanisms and yield properties of hydrated bone extracellular matrix","volume":"60","author":"Schwiedrzik","year":"2017","journal-title":"Acta Biomater"},{"issue":"2","key":"2024012713473913500_jbmr4286-bib-0026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S8756-3282(99)00257-4","article-title":"Normative data for iliac bone histomorphometry in growing children","volume":"26","author":"Glorieux","year":"2000","journal-title":"Bone."},{"issue":"2","key":"2024012713473913500_jbmr4286-bib-0027","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1210\/jc.2005-2036","article-title":"Pamidronate in children with osteogenesis imperfecta: histomorphometric effects of long-term therapy","volume":"91","author":"Rauch","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2024012713473913500_jbmr4286-bib-0028","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.scriptamat.2005.06.043","article-title":"The design of accurate micro-compression experiments","volume":"54","author":"Zhang","year":"2006","journal-title":"Scr Mater."},{"issue":"6","key":"2024012713473913500_jbmr4286-bib-0029","doi-asserted-by":"crossref","first-page":"065002","DOI":"10.1117\/1.JBO.19.6.065002","article-title":"Relationship between the v2PO4\/amide III ratio assessed by Raman spectroscopy and the calcium content measured by quantitative backscattered electron microscopy in healthy human osteonal bone","volume":"19","author":"Roschger","year":"2014","journal-title":"J Biomed Opt."},{"issue":"2","key":"2024012713473913500_jbmr4286-bib-0030","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.bone.2010.04.608","article-title":"Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy","volume":"47","author":"Gamsjaeger","year":"2010","journal-title":"Bone"},{"key":"2024012713473913500_jbmr4286-bib-0031","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.actbio.2017.05.034","article-title":"On the relationship between indentation hardness and modulus, and the damage resistance of biological materials","volume":"57","author":"Labonte","year":"2017","journal-title":"Acta Biomater"},{"issue":"12","key":"2024012713473913500_jbmr4286-bib-0032","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/jbmr.2567","article-title":"Intravenous bisphosphonate therapy of young children with osteogenesis imperfecta: skeletal findings during follow up throughout the growing years","volume":"30","author":"Palomo","year":"2015","journal-title":"J Bone Miner Res."},{"issue":"11","key":"2024012713473913500_jbmr4286-bib-0033","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/nmat4719","article-title":"The nanocomposite nature of bone drives its strength and damage resistance","volume":"15","author":"Tertuliano","year":"2016","journal-title":"Nat Mater."},{"key":"2024012713473913500_jbmr4286-bib-0034","volume-title":"Mechanical properties of bone","author":"Evans","year":"1973","edition":"1st ed"},{"issue":"3","key":"2024012713473913500_jbmr4286-bib-0035","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/aja.1000910302","article-title":"Compact bone as a non-isometric material","volume":"91","author":"Dempster","year":"1952","journal-title":"Am J Anat."},{"key":"2024012713473913500_jbmr4286-bib-0036","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.actbio.2019.03.043","article-title":"Anisotropic elastic properties of human femoral cortical bone and relationships with composition and microstructure in elderly","volume":"90","author":"Cai","year":"2019","journal-title":"Acta Biomater"},{"key":"2024012713473913500_jbmr4286-bib-0037","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.actbio.2020.10.034","article-title":"Combining polarized Raman spectroscopy and micropillar compression to study microscale structure-property relationships in mineralized tissues","volume":"119","author":"Kochetkova","year":"2020","journal-title":"Acta Biomater"},{"key":"2024012713473913500_jbmr4286-bib-0038","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1007\/s10237-020-01328-1","article-title":"An efficient two-scale 3D FE model of the bone fibril array: comparison of anisotropic elastic properties with analytical methods and micro-sample testing","volume":"19","author":"Alizadeh","year":"2020","journal-title":"Biomech Model Mechanobiol"},{"key":"2024012713473913500_jbmr4286-bib-0039","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.actbio.2020.04.030","article-title":"Microtensile properties and failure mechanisms of cortical bone at the lamellar level","volume":"120","author":"Casari","year":"2021","journal-title":"Acta Biomater."},{"key":"2024012713473913500_jbmr4286-bib-0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bonekey.2015.112","article-title":"The fracture mechanics of human bone: influence of disease and treatment","volume":"4","author":"Zimmermann","year":"2015","journal-title":"Bonekey Rep."},{"key":"2024012713473913500_jbmr4286-bib-0041","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jmbbm.2012.11.005","article-title":"Insight into differences in nanoindentation properties of bone","volume":"18","author":"Rodriguez-Florez","year":"2013","journal-title":"J Mech Behav Biomed Mater"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/7\/1364\/55458477\/jbmr4286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/7\/1364\/55458477\/jbmr4286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:06:59Z","timestamp":1710328019000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/36\/7\/1364-1375\/7516741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":41,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,3,19]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4286","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4286\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4286\/v3\/response1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2020-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}