{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:25:31Z","timestamp":1792027531699,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":174,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundaci\u00f3n de Investigaciones Metab\u00f3licas"},{"DOI":"10.13039\/100013220","name":"Ultragenyx Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013220","name":"Ultragenyx Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Some studies based on bone biopsy have demonstrated that in patients with tumor-induced osteomalacia (TIO) the mineralization process of the bone matrix is profoundly disturbed. However, the interrelationship between clinical and biochemical features and bone microarchitecture in this disease needs further analysis. With this purpose in mind, we set out three objectives: (i) to determine bone microarchitecture and estimated bone strength in a group of patients with tumor-induced osteomalacia using high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA), (ii) to investigate correlations between duration of disease, biochemical features, bone density, HR-pQCT and FEA parameters, and (iii) to compare HR-pQCT and FEA parameters with a healthy control group. Ten patients with TIO were included. All patients had non-resolved disease. At the distal radius, all bone microarchitecture parameters were significantly affected in patients with TIO in comparison with healthy controls. At the distal tibia, all parameters were significantly impaired, except for trabecular thickness. All the parameters were more affected in the distal tibia than in the distal radius. Women with TIO (n\u00a0=\u00a07) had significantly lower bone strength parameters than healthy controls. In men (n\u00a0=\u00a03), bone strength parameters were significantly lower than in the control group at the distal tibia. Alkaline phosphatase levels exhibited a negative correlation with microarchitecture parameters, failure load, and stiffness. Higher levels of parathyroid hormone correlated with poorer microarchitecture parameters. We believe that in TIO, hormonal disturbances and the lack of mechanical stimulus specially converge to generate an extremely harmful combination for bone health. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4325","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T20:58:14Z","timestamp":1620248294000},"page":"1502-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Impaired bone microarchitecture and strength in patients with tumor-induced osteomalacia"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-1847","authenticated-orcid":false,"given":"Mar\u00eda Bel\u00e9n","family":"Zanchetta","sequence":"first","affiliation":[{"name":"IDIM, Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas Universidad del Salvador LIBERTAD 836 1 PISO BUENOS AIRES Argentina C1012AAR Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1339-7145","authenticated-orcid":false,"given":"Fernando","family":"Jerkovich","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Endocrinolog\u00eda, Hospital de Cl\u00ednicas Universidad de Buenos Aires Buenos Aires Argentina"},{"name":"IDIM, Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas Universidad del Salvador LIBERTAD 836 1 PISO BUENOS AIRES Argentina C1012AAR Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selva","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"IDIM, Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas Universidad del Salvador LIBERTAD 836 1 PISO BUENOS AIRES Argentina C1012AAR Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamile","family":"Mocarbel","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Endocrinolog\u00eda, Hospital de Cl\u00ednicas Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda","family":"Pignatta","sequence":"additional","affiliation":[{"name":"Servicio de Endocrinolog\u00eda Hospital Interzonal San Juan Bautista San Fernando del Valle de Catamarca Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"El\u00edas","sequence":"additional","affiliation":[{"name":"Servicio de Endocrinolog\u00eda, Metabolismo, Nutrici\u00f3n y Diabetes Hospital Brit\u00e1nico de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Graciela","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n Endocrinolog\u00eda, Hospital de Cl\u00ednicas Universidad de Buenos Aires Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Roganovich","sequence":"additional","affiliation":[{"name":"Cl\u00ednica \u00c1mbar Posadas Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Vigovich","sequence":"additional","affiliation":[{"name":"Hospital Gobernador Centeno General Pico Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Celeste","family":"Balonga","sequence":"additional","affiliation":[{"name":"IDIM, Instituto de Diagn\u00f3stico e Investigaciones Metab\u00f3licas Universidad del Salvador LIBERTAD 836 1 PISO BUENOS AIRES Argentina C1012AAR Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Cohen","sequence":"additional","affiliation":[{"name":"Sanatorio Rivadavia San Miguel de Tucum\u00e1n Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Mumbach","sequence":"additional","affiliation":[{"name":"Instituto de Ortopedia y 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