{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:29:10Z","timestamp":1791404950412,"version":"4.3.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":185,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cStrategic Priority Research Program\u201d of the Chinese Academy of Sciences","award":["XDB38020400"],"award-info":[{"award-number":["XDB38020400"]}]},{"name":"National Key Research and Development Project","award":["2018YFC0910403"],"award-info":[{"award-number":["2018YFC0910403"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16JC1400500"],"award-info":[{"award-number":["16JC1400500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Science and Technology Major Project","award":["2017SHZDZX01"],"award-info":[{"award-number":["2017SHZDZX01"]}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["16JC1400500"],"award-info":[{"award-number":["16JC1400500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Recent advances indicate that bone and energy metabolism are closely related. However, little direct evidence on causality has been provided in humans. We aimed to assess the association of three bone-related biomarkers\u201425 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), and osteocalcin (OCN)\u2014with several metabolic phenotypes and investigate any causal relevance to the associations using a Mendelian randomization (MR) study. Serum 25OHD, PTH, and total OCN were measured at baseline in 5169 eligible Chinese participants in Changfeng study. Partial correlation and bivariate GREML analysis were used to estimate phenotypic and genetic correlations, respectively. Multiple linear regression and logistic regression were used to assess linear associations. Genomewide association analysis (GWAS) was performed. Bidirectional two-sample MR analyses were conducted to examine causal relationships between OCN and body mass index (BMI), diastolic blood pressure (DBP), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), glycated hemoglobin A1c (HbA1c), and type 2 diabetes (T2DM), using our GWAS result of OCN and GWAS statistics from Biobank Japan project (BBJ) and the largest meta-analysis of T2DM GWAS in East Asian population. Circulating OCN was significantly associated with higher DBP and HDL-C and decreased TG, blood glucose level, insulin resistance, liver fat content, bone mineral density, BMI, and a favorable body fat distribution pattern. GWAS identified one novel serum PTH locus and two novel serum OCN loci, explaining 0.81% and 1.98% of variances of PTH and OCN levels, respectively. MR analysis suggested a causal effect of T2DM on lower circulating OCN concentration (causal effect: \u22120.03; \u22120.05 to \u22120.01; p\u00a0=\u00a00.006 for T2DM_BBJ and \u22120.03; \u22120.05 to \u22120.01; p\u00a0=\u00a00.001 for T2DM_EAS). These findings indicate that T2DM might impact bone remodeling and provide a resource for understanding complex relationships between osteocalcin and metabolic (and related) traits in humans. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4330","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T09:54:29Z","timestamp":1620467669000},"page":"1694-1707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9353-6565","authenticated-orcid":false,"given":"Hailuan","family":"Zeng","sequence":"first","affiliation":[{"name":"Human Phenome Institute, Fudan University Shanghai China"},{"name":"Fudan Institute for Metabolic Diseases Shanghai China"},{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyu","family":"Ge","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development School of Life Sciences, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-0165","authenticated-orcid":false,"given":"Mingfeng","family":"Xia","sequence":"additional","affiliation":[{"name":"Fudan Institute for Metabolic Diseases Shanghai China"},{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baishen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huandong","family":"Lin","sequence":"additional","affiliation":[{"name":"Fudan Institute for Metabolic Diseases Shanghai China"},{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China"},{"name":"CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Human Phenome Institute, Fudan University Shanghai China"},{"name":"Fudan Institute for Metabolic Diseases Shanghai China"},{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital, Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"2024012713453853100_jbmr4330-bib-0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2017.02.001","article-title":"Osteocalcin and its endocrine functions","volume":"132","author":"Mizokami","year":"2017","journal-title":"Biochem Pharmacol."},{"issue":"2","key":"2024012713453853100_jbmr4330-bib-0002","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/jbmr.3888","article-title":"Osteocalcin regulates arterial calcification via altered Wnt signaling and glucose metabolism","volume":"35","author":"Rashdan","year":"2020","journal-title":"J Bone Miner 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