{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T13:42:16Z","timestamp":1781962936134,"version":"3.54.5"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":205,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Bruno Farmaceutici S.p.A."},{"name":"Faes Farma S.A."}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vitamin D has shown to play a role in multiple diseases due to its skeletal and extraskeletal actions. Furthermore, vitamin D deficiency has become a worldwide health issue. Few supplementation guidelines mention calcifediol treatment, despite being the direct precursor of calcitriol and the biomarker of vitamin D status. This 1-year, phase III\u2013IV, double-blind, randomized, controlled, multicenter clinical trial assessed the efficacy and safety of calcifediol 0.266 mg soft capsules in vitamin D\u2013deficient postmenopausal women, compared to cholecalciferol. Results reported here are from a prespecified interim analysis, for the evaluation of the study's primary endpoint: the percentage of patients with serum 25-hydroxyvitamin D (25(OH)D) levels above 30\u2009ng\/ml after 4\u2009months. A total of 303 patients were enrolled, of whom 298 were included in the intention-to-treat (ITT) population. Patients with baseline levels of serum 25(OH)D\u2009&amp;lt;20\u2009ng\/ml were randomized 1:1:1 to calcifediol 0.266\u2009mg\/month for 12\u2009months, calcifediol 0.266\u2009mg\/month for 4\u2009months followed by placebo for 8\u2009months, and cholecalciferol 25,000\u2009IU\/month for 12\u2009months. At month 4, 35.0% of postmenopausal women treated with calcifediol and 8.2% of those treated with cholecalciferol reached serum 25(OH)D levels above 30\u2009ng\/ml (p\u2009&amp;lt;\u20090.0001). The most remarkable difference between both drugs in terms of mean change in serum 25(OH)D levels was observed after the first month of treatment (mean \u00b1 standard deviation change\u00a0=\u00a09.7\u2009\u00b1\u20096.7 and 5.1\u2009\u00b1\u20093.5\u2009ng\/ml in patients treated with calcifediol and cholecalciferol, respectively). No relevant treatment-related safety issues were reported in any of the groups studied. These results thus confirm that calcifediol is effective, faster, and more potent than cholecalciferol in raising serum 25(OH)D levels and is a valuable option for the treatment of vitamin D deficiency. \u00a9 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4387","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T05:44:48Z","timestamp":1623217488000},"page":"1967-1978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial"],"prefix":"10.1093","volume":"36","author":[{"given":"Jos\u00e9 Luis","family":"P\u00e9rez-Castrill\u00f3n","sequence":"first","affiliation":[{"name":"School of Medicine Universidad de Valladolid Valladolid Spain"},{"name":"Internal Medicine Department Hospital Universitario R\u00edo Hortega Valladolid 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Reina Sof\u00eda C\u00f3rdoba Spain"},{"name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Galarraga","sequence":"additional","affiliation":[{"name":"Rheumatology Department Hospital Quir\u00f3nsalud Bizkaia Erandio Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Gonz\u00e1lez-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n marqu\u00e9s de Valdecilla (IDIVAL) Santander Spain"},{"name":"School of Medicine Universidad de Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-3763","authenticated-orcid":false,"given":"Roger","family":"Bouillon","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism KU Leuven Leuven 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