{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:11:23Z","timestamp":1791925883340,"version":"4.3.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"am","delay-in-days":568,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":227,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH T32-AR007281"],"award-info":[{"award-number":["NIH T32-AR007281"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["DOD PRMRP W81XWH-17-1-0540"],"award-info":[{"award-number":["DOD PRMRP W81XWH-17-1-0540"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["NIH T32\u2010AR007281"],"award-info":[{"award-number":["NIH T32\u2010AR007281"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["DOD PRMRP W81XWH\u201017\u20101\u20100540"],"award-info":[{"award-number":["DOD PRMRP W81XWH\u201017\u20101\u20100540"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Posttraumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral bone remodeling. Inhibiting altered remodeling immediately following joint damage can slow PTOA progression. Clinically, however, inhibiting remodeling when significant joint damage is already present has minimal effects in slowing further disease progression. We sought to determine the treatment window following PTOA initiation in which inhibiting remodeling can attenuate progression of joint damage. We hypothesized that the most effective treatment would be to inhibit remodeling immediately after PTOA initiation. We used an animal model in which a single bout of mechanical loading was applied to the left tibia of 26-week-old male C57Bl\/6 mice at a peak load of 9 N to initiate load-induced PTOA development. Following loading, we inhibited bone remodeling using daily alendronate (ALN) treatment administered either immediately or with 1 or 2\u2009weeks' delay up to 3 or 6\u2009weeks post-loading. A vehicle (VEH) treatment group controlled for daily injections. Cartilage and subchondral bone morphology and osteophyte development were analyzed and compared among treatment groups. Inhibiting remodeling using ALN immediately after load-induced PTOA initiation reduced cartilage degeneration, slowed osteophyte formation, and preserved subchondral bone volume compared to VEH treatment. Delaying the inhibition of bone remodeling at 1 or 2\u2009weeks similarly attenuated cartilage degeneration at 6\u2009weeks, but did not slow the development of osteoarthritis (OA)-related changes in the subchondral bone, including osteophyte formation and subchondral bone erosions. Immediate inhibition of subchondral bone remodeling was most effective in slowing PTOA progression across the entire joint, indicating that abnormal bone remodeling within the first week following PTOA initiation played a critical role in subsequent cartilage damage, subchondral bone changes, and overall joint degeneration. These results highlight the potential of anti-resorptive drugs as preemptive therapies for limiting PTOA development after joint injury, rather than as disease-modifying therapies after joint damage is established. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4397","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T03:27:47Z","timestamp":1624332467000},"page":"2027-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-2156","authenticated-orcid":false,"given":"Sophia N.","family":"Ziemian","sequence":"first","affiliation":[{"name":"Meinig School of Biomedical Engineering Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Witkowski","sequence":"additional","affiliation":[{"name":"Meinig School of Biomedical Engineering Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Wright","sequence":"additional","affiliation":[{"name":"HSS Research Institute Hospital for Special Surgery New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Otero","sequence":"additional","affiliation":[{"name":"HSS Research Institute Hospital for Special Surgery New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein C. H.","family":"van der Meulen","sequence":"additional","affiliation":[{"name":"Sibley School of Mechanical & Aerospace Engineering Cornell University New York New York USA"},{"name":"HSS Research Institute Hospital for Special Surgery New York New York USA"},{"name":"Meinig School of Biomedical Engineering Cornell University Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"issue":"10182","key":"2024012802581228000_jbmr4397-bib-0001","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet."},{"issue":"9991","key":"2024012802581228000_jbmr4397-bib-0002","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet."},{"issue":"3","key":"2024012802581228000_jbmr4397-bib-0003","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis","volume":"231","author":"Goldring","year":"2007","journal-title":"J Cell Physiol"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0004","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrrheum.2015.135","article-title":"Strategies for the prevention of knee osteoarthritis","volume":"12","author":"Roos","year":"2016","journal-title":"Nat Rev Rheumatol"},{"issue":"9783","key":"2024012802581228000_jbmr4397-bib-0005","doi-asserted-by":"crossref","first-page":"22115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"issue":"12","key":"2024012802581228000_jbmr4397-bib-0006","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.joca.2016.07.017","article-title":"Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future","volume":"24","author":"Karsdal","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0007","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mcna.2008.09.006","article-title":"Role of bone in osteoarthritis pathogenesis","volume":"93","author":"Goldring","year":"2009","journal-title":"Med Clin North Am"},{"key":"2024012802581228000_jbmr4397-bib-0008","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"Goldring","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"2024012802581228000_jbmr4397-bib-0009","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/1759720X12437353","article-title":"Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis","volume":"4","author":"Goldring","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2024012802581228000_jbmr4397-bib-0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-198612000-00005","article-title":"Role of subchondral bone in the initiation and progression of cartilage damage","volume":"213","author":"Radin","year":"1986","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0011","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/art.40351","article-title":"Loading-induced reduction in sclerostin as a mechanism of subchondral bone plate sclerosis in mouse knee joints during late-stage osteoarthritis","volume":"70","author":"Jia","year":"2018","journal-title":"Arthritis Rheumatol"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0012","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1053\/joca.2002.0821","article-title":"A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis","volume":"10","author":"Huebner","year":"2002","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0013","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/art.40382","article-title":"Editorial: Wnt signaling related to subchondral bone density and cartilage degradation in osteoarthritis","volume":"70","author":"Burr","year":"2018","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"2024012802581228000_jbmr4397-bib-0014","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jbmr.3909","article-title":"Articular cartilage degradation and aberrant subchondral bone remodeling in patients with osteoarthritis and osteoporosis","volume":"35","author":"Chu","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0015","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/01.bot.0000246468.80635.ef","article-title":"Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease","volume":"20","author":"Brown","year":"2006","journal-title":"J Orthop Trauma"},{"issue":"8","key":"2024012802581228000_jbmr4397-bib-0016","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrrheum.2013.72","article-title":"Post-traumatic osteoarthritis: from mouse models to clinical trials","volume":"9","author":"Little","year":"2013","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13018-016-0346-5","article-title":"Animal models of osteoarthritis: classification, update, and measurement of outcomes","volume":"11","author":"Kuyinu","year":"2016","journal-title":"J Orthop Surg Res"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0018","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.joca.2016.05.017","article-title":"A novel rat model for subchondral microdamage in acute knee injury: a potential mechanism in post-traumatic osteoarthritis","volume":"24","author":"Ramme","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"2024012802581228000_jbmr4397-bib-0019","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/jor.20331","article-title":"Joint degeneration following closed intraarticular fracture in the mouse knee: a model of posttraumatic arthritis","volume":"25","author":"Furman","year":"2007","journal-title":"J Orthop Res"},{"issue":"8","key":"2024012802581228000_jbmr4397-bib-0020","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.joca.2014.05.023","article-title":"Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies","volume":"22","author":"Yuan","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"2024012802581228000_jbmr4397-bib-0021","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0022","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bone.2005.08.007","article-title":"Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis","volume":"38","author":"Hayami","year":"2006","journal-title":"Bone"},{"issue":"12","key":"2024012802581228000_jbmr4397-bib-0023","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1002\/art.10630","article-title":"Evidence for increased bone resorption in patients with progressive knee osteoarthritis: longitudinal results from the Chingford study","volume":"46","author":"Bettica","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"5","key":"2024012802581228000_jbmr4397-bib-0024","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1053\/joca.1999.0241","article-title":"Evidence of early subchondral bone changes in the meniscectomized guinea pig. A densitometric study using dual-energy X-ray absorptiometry subregional analysis","volume":"7","author":"Pastoureau","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2302\/kjm.58.29","article-title":"New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?","volume":"58","author":"Tat","year":"2009","journal-title":"Keio J Med"},{"issue":"6","key":"2024012802581228000_jbmr4397-bib-0026","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00198-007-0540-8","article-title":"Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy","volume":"19","author":"Russell","year":"2008","journal-title":"Osteoporos Int"},{"issue":"4","key":"2024012802581228000_jbmr4397-bib-0027","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1002\/art.20124","article-title":"The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model","volume":"50","author":"Hayami","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"7","key":"2024012802581228000_jbmr4397-bib-0028","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.joca.2012.03.021","article-title":"Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation","volume":"20","author":"Panahifar","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0029","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1002\/jor.21394","article-title":"Chondroprotective effect of alendronate in a rabbit model of osteoarthritis","volume":"29","author":"Shirai","year":"2011","journal-title":"J Orthop Res"},{"issue":"4","key":"2024012802581228000_jbmr4397-bib-0030","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10238-011-0131-z","article-title":"Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis","volume":"11","author":"Zhang","year":"2011","journal-title":"Clin Exp Med"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-015-0546-0","article-title":"Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice","volume":"17","author":"Khorasani","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"2024012802581228000_jbmr4397-bib-0032","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1002\/art.22160","article-title":"Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study","volume":"54","author":"Bingham","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"3","key":"2024012802581228000_jbmr4397-bib-0033","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1186\/ar1716","article-title":"Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]","volume":"7","author":"Spector","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"2024012802581228000_jbmr4397-bib-0034","doi-asserted-by":"crossref","first-page":"e72714","DOI":"10.1371\/journal.pone.0072714","article-title":"Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review","volume":"8","author":"Davis","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0035","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3349\/ymj.2010.51.2.164","article-title":"Effects of risedronate on osteoarthritis of the knee","volume":"51","author":"Iwamoto","year":"2010","journal-title":"Yonsei Med J"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0036","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.joca.2013.06.020","article-title":"Pre-emptive, early, and delayed alendronate treatment in a rat model of knee osteoarthritis: effect on subchondral trabecular bone microarchitecture and cartilage degradation of the tibia, bone\/cartilage turnover, and joint discomfort","volume":"21","author":"Mohan","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"2024012802581228000_jbmr4397-bib-0037","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/jor.23204","article-title":"Progressive cell-mediated changes in articular cartilage and bone in mice are initiated by a single session of controlled cyclic compressive loading","volume":"34","author":"Ko","year":"2016","journal-title":"J Orthop Res"},{"issue":"Suppl 3","key":"2024012802581228000_jbmr4397-bib-0038","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0039","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/jor.23731","article-title":"Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice","volume":"36","author":"Holyoak","year":"2018","journal-title":"J Orthop Res"},{"issue":"12","key":"2024012802581228000_jbmr4397-bib-0040","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.joca.2017.08.016","article-title":"Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice","volume":"25","author":"Adebayo","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"2024012802581228000_jbmr4397-bib-0041","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0042","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jbmr.2082","article-title":"Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength","volume":"29","author":"Melville","year":"2014","journal-title":"J Bone Miner Res"},{"key":"2024012802581228000_jbmr4397-bib-0043","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bone.2014.06.009","article-title":"Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression","volume":"66","author":"Siebelt","year":"2014","journal-title":"Bone"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0044","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/joca.2002.0873","article-title":"Osteophyte development - molecular characterization of differentiation stages","volume":"11","author":"Gelse","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ard.34.1.12","article-title":"Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone labelling techniques","volume":"34","author":"Gilbertson","year":"1975","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"2024012802581228000_jbmr4397-bib-0046","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","article-title":"Osteophytes: relevance and biology","volume":"15","author":"van der Kraan","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"2024012802581228000_jbmr4397-bib-0047","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.joca.2015.11.006","article-title":"Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis","volume":"24","author":"Kwok","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0048","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13075-020-02261-5","article-title":"Meniscal and ligament modifications in spontaneous and post-traumatic mouse models of osteoarthritis","volume":"22","author":"Ramos-Mucci","year":"2020","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"2024012802581228000_jbmr4397-bib-0049","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joca.2012.04.014","article-title":"Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis","volume":"20","author":"Christiansen","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"2024012802581228000_jbmr4397-bib-0050","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jor.22509","article-title":"Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis","volume":"32","author":"Onur","year":"2014","journal-title":"J Orthop Res"},{"key":"2024012802581228000_jbmr4397-bib-0051","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jbiomech.2018.04.014","article-title":"Comparison of knee injury threshold during tibial compression based on limb orientation in mice","volume":"74","author":"Hsia","year":"2018","journal-title":"J Biomech"},{"issue":"6","key":"2024012802581228000_jbmr4397-bib-0052","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1002\/art.37906","article-title":"In vivo cyclic compression causes cartilage degeneration and subchondral bone changes in mouse tibiae","volume":"65","author":"Ko","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0053","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.joca.2019.06.005","article-title":"Low-level cyclic tibial compression attenuates early osteoarthritis progression after joint injury in mice","volume":"27","author":"Holyoak","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"2024012802581228000_jbmr4397-bib-0054","article-title":"Repeated intra-articular injection of zoledronic acid modulates chondrocyte proliferation and death in murine post-traumatic osteoarthritis","volume":"43","author":"David","year":"2018","journal-title":"Trans Annu Meet Orthop Res\u00a0Soc"},{"issue":"10","key":"2024012802581228000_jbmr4397-bib-0055","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/ard.61.10.925","article-title":"Effect of bisphosphonates on viability, proliferation, and dexamethasone-induced apoptosis of articular chondrocytes","volume":"61","author":"Van Offel","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2024012802581228000_jbmr4397-bib-0056","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jbspin.2006.06.005","article-title":"Extra-skeletal effects of bisphosphonates","volume":"74","author":"Corrado","year":"2007","journal-title":"Joint Bone Spine"},{"issue":"8","key":"2024012802581228000_jbmr4397-bib-0057","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","article-title":"Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis","volume":"12","author":"Blom","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"2024012802581228000_jbmr4397-bib-0058","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s11914-018-0464-6","article-title":"Current understanding of epidemiology, pathophysiology, and management of atypical femur fractures","volume":"16","author":"Starr","year":"2018","journal-title":"Curr Osteoporos Rep"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/asbmr.onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002\/jbmr.4397","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/10\/2027\/56289699\/jbmr4397.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/10\/2027\/56289699\/jbmr4397.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:07:42Z","timestamp":1710328062000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/36\/10\/2027-2038\/7516546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,6,22]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4397","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4397\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4397\/v4\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2020-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}