{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:29:31Z","timestamp":1774963771687,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical and Translational Science Award","award":["UL1TR001422"],"award-info":[{"award-number":["UL1TR001422"]}]},{"name":"Department of Defense U.S. Army Medical Research and Materiel Command","award":["SC130125; contract# W81XWH-14-2-0193"],"award-info":[{"award-number":["SC130125; contract# W81XWH-14-2-0193"]}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>A single infusion of zoledronic acid (ZOL) after acute spinal cord injury (SCI) attenuates bone loss at the hip (proximal femur) and knee (distal femur and proximal tibia) for at least 6\u2009months. The objective of this study was to examine the effects of timing and frequency of ZOL over 2\u2009years. In this double-blind, placebo-controlled trial, we randomized 60 individuals with acute SCI (&amp;lt;120\u2009days of injury) to receive either ZOL 5-mg infusion (n\u00a0=\u00a030) or placebo (n\u00a0=\u00a030). After 12\u2009months, groups were again randomized to receive ZOL or placebo, resulting in four treatment groups for year 2: (i) ZOL both years; (ii) ZOL year 1, placebo year 2; (iii) placebo year 1, ZOL year 2; and (iv) placebo both years. Our primary outcome was bone loss at 12\u2009months; compared to placebo, a single infusion of ZOL attenuated bone loss at the proximal femur, where median changes relative to baseline were \u22121.7% to \u22122.2% for ZOL versus \u221211.3% to \u221212.8% for placebo (p\u2009&amp;lt;\u20090.001). Similarly, the distal femur and proximal tibia showed changes of \u22124.7% to \u22129.6% for ZOL versus \u22128.9% to \u221223.0% for placebo (p\u2009\u2264\u20090.042). After 24\u2009months, differences were significant at the proximal femur only (\u22123.2% to \u22126.0% for ZOL vs. \u221216.8% to \u221221.8% for placebo; p\u2009\u2264\u20090.018). Although not statistically significant, median bone density losses suggested some benefit from two annual infusions compared to a single baseline infusion, as well as from a single infusion 12\u2009months after baseline compared to 2\u2009years of placebo; therefore, further investigation in the 12-month to 24-month treatment window is warranted. No unanticipated adverse events associated with drug treatment were observed. In summary, ZOL 5-mg infusion after acute SCI was well-tolerated and may provide an effective therapeutic approach to prevent bone loss in the first few years following SCI. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4416","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T03:26:26Z","timestamp":1626665186000},"page":"2127-2138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Durability and delayed treatment effects of zoledronic acid on bone loss after spinal cord injury: a randomized, controlled trial"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3623-9764","authenticated-orcid":false,"given":"W. 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