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In this study, a retrospective review of patients with CED evaluated at Peking Union Medical College Hospital in Beijing, China, between November 30, 2000 and November 30, 2020 was conducted. Data including demographic data, manifestations, and examination results were characterized. Furthermore, bone geometry, density, and microarchitecture were assessed and bone strength was estimated by HR-pQCT. Results showed the median age at onset was 2.5\u2009years. Common manifestations included pain in the lower limbs (94%, 17\/18), abnormal gait (89%, 16\/18), genu valgum (89%, 16\/18), reduced subcutaneous fat (78%, 14\/18), delayed puberty (73%, 8\/11), muscle weakness (67%, 12\/18), hearing loss (39%, 7\/18), hepatosplenomegaly (39%, 7\/18), exophthalmos or impaired vision or visual field defect (33%, 6\/18), and anemia (33%, 7\/18). Twenty-five percent (4\/16) of patients had short stature. Serum level of alkaline phosphatase was elevated in 41% (7\/17) of patients whereas beta-C-terminal telopeptide was elevated in 91% of patients (10\/11). Among 12 patients, the Z-scores of two patients were greater than 2.5 at the femur neck and the Z-scores of five patients were lower than \u22122.5 at the femur neck and\/or lumbar spine. HR-pQCT results showed lower volumetric BMD (vBMD), altered bone microstructure and lower estimated bone strength at the distal radius and tibia in patients with CED compared with controls. In addition, total volume bone mineral density and cortical volumetric bone mineral density at the radius were negatively correlated with age in patients with CED, but positively correlated with age in controls. In conclusion, the largest case series of CED with characterized clinical features in a Chinese population was reported here. In addition, HR-pQCT was used to investigate bone microstructure at the distal radius and tibia in nine patients with CED, and the alteration of bone density, microstructure, and strength was shown for the first time. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4436","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T05:50:35Z","timestamp":1630993835000},"page":"78-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alteration of Bone Density, Microarchitecture, and Strength in Patients with Camurati\u2013Engelmann Disease: Assessed by HR-pQCT"],"prefix":"10.1093","volume":"37","author":[{"given":"Qian","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology, NHC, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, 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Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijia","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology, NHC, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Key Laboratory of Endocrinology, NHC, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing 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