{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:57:03Z","timestamp":1774389423367,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":308,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although bone fragility may already be present at diagnosis of pediatric acute lymphoblastic leukemia (ALL), routine performance of dual-energy X-ray absorptiometry (DXA) in every child is not universally feasible. The aim of this study was to develop and validate a risk prediction model for low lumbar spine bone mineral density (LS BMD Z-score\u2009\u2264\u2009\u22122.0) at diagnosis, as an important indicator for fracture risk and further treatment-related BMD aggravation. Children with ALL (4\u201318\u2009years), treated according to the Dutch Childhood Oncology Group protocol (DCOG-ALL9; model development; n\u00a0=\u00a0249) and children from the Canadian Steroid-Associated Osteoporosis in the Pediatric Population cohort (STOPP; validation; n\u00a0=\u00a099) were included in this study. Multivariable logistic regression analyses were used to develop the prediction model and to confirm the association of low LS BMD at diagnosis with symptomatic fractures during and shortly after cessation of ALL treatment. The area under the receiver operating characteristic curve (AUC) was used to assess model performance. The prediction model for low LS BMD at diagnosis using weight (\u03b2\u00a0=\u00a0\u22120.70) and age (\u03b2\u00a0=\u00a0\u22120.10) at diagnosis revealed an AUC of 0.71 (95% CI, 0.63\u20130.78) in DCOG-ALL9 and 0.74 (95% CI, 0.63\u20130.84) in STOPP, and resulted in correct identification of 71% of the patients with low LS BMD. We confirmed that low LS BMD at diagnosis is associated with LS BMD at treatment cessation (OR 5.9; 95% CI, 3.2\u201310.9) and with symptomatic fractures (OR 1.7; 95% CI, 1.3\u20132.4) that occurred between diagnosis and 12\u2009months following treatment cessation. In meta-analysis, LS BMD at diagnosis (OR 1.6; 95% CI, 1.1\u20132.4) and the 6-month cumulative glucocorticoid dose (OR 1.9; 95% CI, 1.1\u20133.2) were associated with fractures that occurred in the first year of treatment. In summary, a prediction model for identifying pediatric ALL patients with low LS BMD at diagnosis, as an important indicator for bone fragility, was successfully developed and validated. This can facilitate identification of future bone fragility in individual pediatric ALL patients. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4442","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T00:01:10Z","timestamp":1633651270000},"page":"2290-2299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Validated Risk Prediction Model for Bone Fragility in Children With Acute Lymphoblastic Leukemia"],"prefix":"10.1093","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-3363","authenticated-orcid":false,"given":"Emma J.","family":"Verwaaijen","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hester A.","family":"de Groot-Kruseman","sequence":"additional","affiliation":[{"name":"Dutch Childhood Oncology Group Utrecht The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge M.","family":"van der Sluis","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-0089","authenticated-orcid":false,"given":"Jenneke E.","family":"van Atteveld","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Halton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conrad V.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelies","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Pediatric Physiotherapy Erasmus MC-Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"de Jonge","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Academic Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten H.","family":"Lequin","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00ebl L.","family":"te Winkel","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Alos","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie Universit\u00e9 de Montr\u00e9al Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie A.","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McMaster University Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald M.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hay","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Brock University St. Catharines ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Jaremko","sequence":"additional","affiliation":[{"name":"Department of Radiology & Diagnostic Imaging University of Alberta Edmonton AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaldoun","family":"Koujok","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dalhousie University Halifax NS Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary-Ann","family":"Matzinger","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazih","family":"Shenouda","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-0360","authenticated-orcid":false,"given":"Frank","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics McGill University Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Rodd","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Manitoba Winnipeg MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia M.F.","family":"Pluijm","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1557-9185","authenticated-orcid":false,"given":"Leanne M.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Ottawa Ottawa ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The DCOG-ALL9 and Canadian STOPP Consortia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"issue":"1","key":"2024012713454558800_jbmr4442-bib-0001","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1470-2045(13)70548-5","article-title":"Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5\u2013a population-based study","volume":"15","author":"Gatta","year":"2014","journal-title":"Lancet Oncol"},{"issue":"22","key":"2024012713454558800_jbmr4442-bib-0002","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1200\/JCO.2015.64.6364","article-title":"Successful therapy reduction and intensification for childhood acute lymphoblastic leukemia based on minimal residual disease monitoring: Study ALL10 from the Dutch Childhood Oncology Group","volume":"34","author":"Pieters","year":"2016","journal-title":"J Clin Oncol"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0003","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.seminhematol.2013.06.007","article-title":"A 50-year journey to cure childhood acute lymphoblastic leukemia","volume":"50","author":"Pui","year":"2013","journal-title":"Semin Hematol"},{"issue":"9","key":"2024012713454558800_jbmr4442-bib-0004","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1210\/JC.2015-2176","article-title":"Incident vertebral fractures in children with leukemia during the four years following diagnosis","volume":"100","author":"Cummings","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2024012713454558800_jbmr4442-bib-0005","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bone.2013.11.017","article-title":"Bone mineral density at diagnosis determines fracture rate in children with acute lymphoblastic leukemia treated according to the DCOG-ALL9 protocol","volume":"59","author":"te Winkel","year":"2014","journal-title":"Bone"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0006","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11914-014-0222-3","article-title":"Bone morbidity in childhood leukemia: epidemiology, mechanisms, diagnosis, and treatment","volume":"12","author":"Mostoufi-Moab","year":"2014","journal-title":"Curr Osteoporos Rep"},{"issue":"8","key":"2024012713454558800_jbmr4442-bib-0007","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/jbmr.3447","article-title":"Bone morbidity and recovery in children with acute lymphoblastic leukemia: Results of a six-year prospective cohort study","volume":"33","author":"Ward","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"22","key":"2024012713454558800_jbmr4442-bib-0008","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1200\/JCO.2011.40.4830","article-title":"High incidence of vertebral fractures in children with acute lymphoblastic leukemia 12 months after the initiation of therapy","volume":"30","author":"Alos","year":"2012","journal-title":"J Clin Oncol"},{"issue":"7","key":"2024012713454558800_jbmr4442-bib-0009","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1359\/jbmr.090202","article-title":"Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: Results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program","volume":"24","author":"Halton","year":"2009","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0010","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1067\/mpd.2002.125728","article-title":"Altered bone mineral density and body composition, and increased fracture risk in childhood acute lymphoblastic leukemia","volume":"141","author":"van der Sluis","year":"2002","journal-title":"J Pediatr"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0011","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1210\/jc.2018-01083","article-title":"Impact of vertebral fractures and glucocorticoid exposure on height deficits in children during treatment of leukemia","volume":"104","author":"Ma","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024012713454558800_jbmr4442-bib-0012","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3324\/haematol.2015.125583","article-title":"Aggravated bone density decline following symptomatic osteonecrosis in children with acute lymphoblastic leukemia","volume":"100","author":"Den Hoed","year":"2015","journal-title":"Haematologica"},{"issue":"21","key":"2024012713454558800_jbmr4442-bib-0013","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1200\/JCO.2015.64.9525","article-title":"Modifiable factors associated with aging phenotypes among adult survivors of childhood acute lymphoblastic leukemia","volume":"34","author":"Wilson","year":"2016","journal-title":"J Clin Oncol"},{"issue":"10","key":"2024012713454558800_jbmr4442-bib-0014","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1470-2045(09)70228-1","article-title":"Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004)","volume":"10","author":"Veerman","year":"2009","journal-title":"Lancet Oncol"},{"issue":"9","key":"2024012713454558800_jbmr4442-bib-0015","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024012713454558800_jbmr4442-bib-0016","doi-asserted-by":"crossref","first-page":"e2088","DOI":"10.1210\/clinem\/dgz294","article-title":"A contemporary view of the definition and diagnosis of osteoporosis in children and adolescents","volume":"105","author":"Ward","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2024012713454558800_jbmr4442-bib-0017","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/pbc.24040","article-title":"Predictors of bony morbidity in children with acute lymphoblastic leukemia","volume":"59","author":"Rayar","year":"2012","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"2024012713454558800_jbmr4442-bib-0018","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00043426-199807000-00008","article-title":"Longitudinal evaluation of bone mineral density in children receiving chemotherapy","volume":"20","author":"Henderson","year":"1998","journal-title":"J Pediatr Hematol Oncol"},{"issue":"1","key":"2024012713454558800_jbmr4442-bib-0019","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11657-016-0290-3","article-title":"Bone mineral density in children with acute leukemia and its associated factors in Iran: a case-control study","volume":"11","author":"Bordbar","year":"2016","journal-title":"Arch Osteoporos"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0020","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00198-011-1605-2","article-title":"Predictors of bone loss in childhood hematologic malignancies: a prospective study","volume":"23","author":"El-Hajj Fuleihan","year":"2012","journal-title":"Osteoporosis Int"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0021","first-page":"1","article-title":"Mice: multivariate imputation by chained equations in R","volume":"45","author":"van Buuren","year":"2011","journal-title":"J Stat Softw"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0022","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4172\/2161-1165.1000227","article-title":"Multicollinearity in regression analyses conducted in epidemiologic studies","volume":"6","author":"Vatcheva","year":"2016","journal-title":"Epidemiology (Sunnyvale)"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0023","first-page":"30","article-title":"Multiple imputation with multivariate imputation by chained equation (MICE) package","volume":"4","author":"Zhang","year":"2016","journal-title":"Ann Transl Med"},{"key":"2024012713454558800_jbmr4442-bib-0024","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/0471722146.ch5","volume-title":"Applied Logistic Regression","author":"Hosmer","year":"2000"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0025","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1365-2362.2011.02562.x","article-title":"Assessing the incremental value of diagnostic and prognostic markers: a review and illustration","volume":"42","author":"Steyerberg","year":"2012","journal-title":"Eur J Clin Invest"},{"issue":"25","key":"2024012713454558800_jbmr4442-bib-0026","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1200\/JCO.18.01917","article-title":"Prediction of low and very low bone mineral density among adult survivors of childhood cancer","volume":"37","author":"van Atteveld","year":"2019","journal-title":"J Clin Oncol"},{"key":"2024012713454558800_jbmr4442-bib-0027","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fendo.2020.00200","article-title":"The bones of children with obesity","volume":"11","author":"Fintini","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"7","key":"2024012713454558800_jbmr4442-bib-0028","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/pbc.25010","article-title":"Bone mineral density among long-term survivors of childhood acute lymphoblastic leukemia: results from the St. Jude Lifetime Cohort study","volume":"61","author":"Gurney","year":"2014","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0029","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/pbc.25324","article-title":"Catch-up of bone mineral density among long-term survivors of childhood cancer? Letter to the editor: response to the article of Gurney et al. 2014","volume":"62","author":"Pluijm","year":"2015","journal-title":"Pediatr Blood Cancer"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0030","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.bone.2010.10.163","article-title":"Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study","volume":"48","author":"te Winkel","year":"2011","journal-title":"Bone"},{"issue":"5","key":"2024012713454558800_jbmr4442-bib-0031","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3324\/haematol.2009.016303","article-title":"Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia","volume":"95","author":"te Winkel","year":"2010","journal-title":"Haematologica"},{"issue":"7","key":"2024012713454558800_jbmr4442-bib-0032","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1200\/JCO.2004.04.199","article-title":"Skeletal morbidity in childhood acute lymphoblastic leukemia","volume":"22","author":"Mandel","year":"2004","journal-title":"J Clin Oncol"},{"issue":"2 suppl","key":"2024012713454558800_jbmr4442-bib-0033","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/pbc.21407","article-title":"Osteoporosis in children with cancer","volume":"50","author":"van der Sluis","year":"2008","journal-title":"Pediatr Blood Cancer"},{"issue":"12","key":"2024012713454558800_jbmr4442-bib-0034","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1200\/JCO.2007.13.8404","article-title":"Asparaginase may influence dexamethasone pharmacokinetics in acute lymphoblastic leukemia","volume":"26","author":"Yang","year":"2008","journal-title":"J Clin Oncol"},{"issue":"12","key":"2024012713454558800_jbmr4442-bib-0035","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1359\/JBMR.050820","article-title":"Bone and body composition of children and adolescents with repeated forearm fractures","volume":"20","author":"Goulding","year":"2005","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2024012713454558800_jbmr4442-bib-0036","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1002\/cncr.21706","article-title":"Decrease in motor performance in children with cancer is independent of the cumulative dose of vincristine","volume":"106","author":"Hartman","year":"2006","journal-title":"Cancer"},{"issue":"1","key":"2024012713454558800_jbmr4442-bib-0037","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/pbc.21942","article-title":"A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia","volume":"53","author":"Hartman","year":"2009","journal-title":"Pediatr Blood Cancer"},{"issue":"2","key":"2024012713454558800_jbmr4442-bib-0038","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jocd.2014.01.003","article-title":"Dual-energy X-ray absorptiometry interpretation and reporting in children and adolescents: the revised 2013 ISCD pediatric official positions","volume":"17","author":"Crabtree","year":"2014","journal-title":"J Clin Densitom"},{"issue":"4","key":"2024012713454558800_jbmr4442-bib-0039","doi-asserted-by":"crossref","first-page":"e20162398","DOI":"10.1542\/peds.2016-2398","article-title":"Bone densitometry in children and adolescents","volume":"138","author":"Bachrach","year":"2016","journal-title":"Pediatrics"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0040","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1210\/jc.2014-3096","article-title":"The choice of normative pediatric reference database changes spine bone mineral density Z-scores but not the relationship between bone mineral density and prevalent vertebral fractures","volume":"100","author":"Ma","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0041","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00198-017-4337-0","article-title":"Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women","volume":"29","author":"Watanabe","year":"2018","journal-title":"Osteoporos Int"},{"issue":"3","key":"2024012713454558800_jbmr4442-bib-0042","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/jbmr.3922","article-title":"The accuracy of prevalent vertebral fracture detection in children using targeted case-finding approaches","volume":"35","author":"Ma","year":"2020","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/12\/2290\/55453627\/jbmr4442.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/36\/12\/2290\/55453627\/jbmr4442.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:03Z","timestamp":1710328083000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/36\/12\/2290-2299\/7516477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":42,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,10,5]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4442","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4442\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4442\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4442\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4442\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4442\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4442\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}