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Body weight and biochemical parameters improved significantly in the CKD\u2009+\u2009cinacalcet groups compared to the CKD group. Micro\u2013computed tomography (\u03bcCT) revealed both cortical and trabecular parameters deteriorated significantly in the CKD group and were reversed by cinacalcet in a dose-dependent manner. Nanoindentation analysis of bone quality proved that both cortical hardness and elastic modulus improved significantly with high dose cinacalcet treatment. In vitro studies revealed that cinacalcet inhibited receptor activator of NF-\u03baB ligand (RANKL)\/receptor activator of NF-\u03baB (RANK)\u2013induced OC differentiation in a concentration-dependent manner through a close interaction between activation of caspase-related apoptosis, reversal of OC autophagy through the protein kinase B (Akt)\/mammalian target of rapamycin (mTOR) and adenosine monophosphate\u2013activated protein kinase (AMPK) pathways, and attenuation of the OC ER stress\/CREBH\/NFATc1 signaling pathway. Cinacalcet improves both bone quantity and bone quality in CKD mouse model and inhibits OC differentiation through regulation of the interactions among the apoptosis, ER stress, and autophagy pathways within OCs. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4459","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T09:52:25Z","timestamp":1633945945000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cinacalcet Improves Bone Parameters Through Regulation of Osteoclast Endoplasmic Reticulum Stress, Autophagy, and Apoptotic Pathways in Chronic Kidney Disease\u2013Mineral and Bone Disorder"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-390X","authenticated-orcid":false,"given":"Hui-Wen","family":"Chiu","sequence":"first","affiliation":[{"name":"Department of Medical 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