{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:17:20Z","timestamp":1790309840027,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":343,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fondation pour la Recherche sur l'Ost\u00e9oporose et les Maladies Osseuses de Gen\u00e8ve."},{"name":"Geneva University Hospitals and Faculty of Medicine Clinical Research Center"},{"name":"HUG Private Foundation"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Atypical femoral fractures (AFFs) occurring during the course of osteoporosis treatment usually lead to discontinuation of anti-resorptive (AR) drugs. However, the risk of fracture after an AFF is unknown. We conducted a follow-up study of patients with AFF matched 1:3 for age and gender with patients with a peripheral major osteoporotic fracture (pMOF), in the setting of a fracture liaison service, to investigate the incidence of subsequent low-trauma fractures. Fifty-five patients with AFF (95% women, age [mean\u2009\u00b1\u2009standard deviation] 75\u2009\u00b1\u200910\u2009years, 89% exposed to AR drugs), followed for 6.2\u2009\u00b1\u20093.7\u2009years, were compared to 165 matched controls with a pMOF (hip 85%) followed for 4.3\u2009\u00b1\u20092.6\u2009years. During the follow-up, 38% of patients in the AFF group and 16% in the pMOF group received AR therapies. Continuation of AR drugs after an AFF was associated with contralateral AFF in 27% of subjects. The risks of new low-trauma, major osteoporotic and imminent (within 2\u2009years) fractures, were similar between the two groups: incidence rate ratio (95% confidence interval [CI]) of subsequent fracture following AFF relative to pMOF, 1.30 (95% CI, 0.82\u20132.04), 1.28 (95% CI, 0.74\u20132.15), and 1.11 (95% CI, 0.54\u20132.15), respectively. Moreover, the risk of sustaining multiple fractures per participant was significantly increased among patients with AFF compared to pMOF (hazard ratio 1.48 [95% CI, 1.00\u20132.19]; p\u00a0=\u00a00.049). When taking mortality into account, the risk of subsequent fractures tended to be higher in the AFF group (sub-hazard ratio 1.42 [95% CI, 0.95\u20132.12]). In conclusion, patients who sustained an AFF are at high risk of subsequent fragility fractures, at least equal or even greater to the risk observed after a pMOF. However, continuation of AR drugs increases the risk of contralateral AFF. Therefore, optimal modalities for secondary fracture prevention after AFF require further evaluation. \u00a9 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4461","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T18:21:39Z","timestamp":1634754099000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fracture Risk Following an Atypical Femoral Fracture"],"prefix":"10.1093","volume":"37","author":[{"given":"Marie-Jos\u00e9e","family":"B\u00e9gin","sequence":"first","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claude","family":"Audet","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-1148","authenticated-orcid":false,"given":"Thierry","family":"Chevalley","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Portela","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Padlina","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Hannouche","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuntheavy","family":"Ing Lorenzini","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Peter","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery, Department of Surgery, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Uebelhart","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Rizzoli","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1372-4417","authenticated-orcid":false,"given":"Serge","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6174-1951","authenticated-orcid":false,"given":"Emmanuel","family":"Biver","sequence":"additional","affiliation":[{"name":"Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"issue":"10","key":"2024012714045216100_jbmr4461-bib-0001","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1056\/NEJMc1403799","article-title":"Risk of atypical femoral fracture during and after bisphosphonate use","volume":"371","author":"Schilcher","year":"2014","journal-title":"N Engl J Med"},{"issue":"12","key":"2024012714045216100_jbmr4461-bib-0002","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1210\/jc.2012-2590","article-title":"Atypical femur fractures: 81 individual personal histories","volume":"97","author":"Schneider","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2024012714045216100_jbmr4461-bib-0003","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1007\/s00198-019-05112-5","article-title":"Atypical femur fracture incidence in women increases with duration of bisphosphonate exposure","volume":"30","author":"Lo","year":"2019","journal-title":"Osteoporos Int"},{"issue":"12","key":"2024012714045216100_jbmr4461-bib-0004","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1002\/jbmr.1719","article-title":"Incidence of atypical nontraumatic diaphyseal fractures of the femur","volume":"27","author":"Dell","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2024012714045216100_jbmr4461-bib-0005","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1001\/archinternmed.2012.1796","article-title":"Increasing occurrence of atypical femoral fractures associated with bisphosphonate use","volume":"172","author":"Meier","year":"2012","journal-title":"Arch Intern Med"},{"issue":"2","key":"2024012714045216100_jbmr4461-bib-0006","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1210\/er.2018-00001","article-title":"Atypical femur fractures: review of epidemiology, relationship to bisphosphonates, prevention, and clinical management","volume":"40","author":"Black","year":"2019","journal-title":"Endocr Rev"},{"issue":"7","key":"2024012714045216100_jbmr4461-bib-0007","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1210\/jc.2012-1027","article-title":"Benefits and risks of bisphosphonate therapy for osteoporosis","volume":"97","author":"Khosla","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2024012714045216100_jbmr4461-bib-0008","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1056\/NEJMoa1916525","article-title":"Atypical femur fracture risk versus fragility fracture prevention with bisphosphonates","volume":"383","author":"Black","year":"2020","journal-title":"N Engl J Med"},{"issue":"1","key":"2024012714045216100_jbmr4461-bib-0009","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3109\/17453674.2015.1004149","article-title":"Risk of atypical femoral fracture during and after bisphosphonate use","volume":"86","author":"Schilcher","year":"2015","journal-title":"Acta Orthop"},{"issue":"1","key":"2024012714045216100_jbmr4461-bib-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jbmr.1998","article-title":"Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research","volume":"29","author":"Shane","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024012714045216100_jbmr4461-bib-0011","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1302\/0301-620X.96B5.32887","article-title":"Post-operative outcomes of atypical femoral subtrochanteric fracture in patients on bisphosphonate therapy","volume":"96-B","author":"Teo","year":"2014","journal-title":"Bone Joint J"},{"issue":"9","key":"2024012714045216100_jbmr4461-bib-0012","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1007\/s11999-013-2963-1","article-title":"Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails","volume":"472","author":"Egol","year":"2014","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"2024012714045216100_jbmr4461-bib-0013","first-page":"14","article-title":"Surgical complications associated with atypical femur fractures attributed to bisphosphonate use","volume":"27","author":"Schultz","year":"2018","journal-title":"J Surg Orthop Adv"},{"issue":"3","key":"2024012714045216100_jbmr4461-bib-0014","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jbmr.2767","article-title":"Mortality after atypical femoral fractures: a cohort study","volume":"31","author":"Kharazmi","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024012714045216100_jbmr4461-bib-0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.297.4.387","article-title":"Risk of subsequent fracture after low-trauma fracture in men and women","volume":"297","author":"Center","year":"2007","journal-title":"JAMA"},{"issue":"6","key":"2024012714045216100_jbmr4461-bib-0016","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00198-017-3976-5","article-title":"Imminent fracture risk","volume":"28","author":"Roux","year":"2017","journal-title":"Osteoporos Int"},{"issue":"9","key":"2024012714045216100_jbmr4461-bib-0017","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2165\/00002018-200932090-00002","article-title":"Low-energy femoral fractures associated with the long-term use of bisphosphonates: a case series from a Swiss university hospital","volume":"32","author":"Ing-Lorenzini","year":"2009","journal-title":"Drug Saf"},{"issue":"6","key":"2024012714045216100_jbmr4461-bib-0018","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s001980200053","article-title":"An osteoporosis clinical pathway for the medical management of patients with low-trauma fracture","volume":"13","author":"Chevalley","year":"2002","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024012714045216100_jbmr4461-bib-0019","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jbmr.3584","article-title":"Prevalence and characteristics of atypical periprosthetic femoral fractures","volume":"34","author":"Leclerc","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2024012714045216100_jbmr4461-bib-0020","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/j.injury.2018.09.014","article-title":"Frequency and associated factor of atypical periprosthetic femoral fracture after hip arthroplasty","volume":"49","author":"Lee","year":"2018","journal-title":"Injury"},{"issue":"10","key":"2024012714045216100_jbmr4461-bib-0021","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1302\/0301-620X.101B10.BJJ-2019-0599.R2","article-title":"Periprosthetic atypical femoral fractures exist and are associated with duration of bisphosphonate therapy","volume":"101-B","author":"MacKenzie","year":"2019","journal-title":"Bone Joint J"},{"issue":"4","key":"2024012714045216100_jbmr4461-bib-0022","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/BOT.0000000000000508","article-title":"Periprosthetic atypical femoral fractures in patients on long-term bisphosphonates: a multicenter retrospective review","volume":"30","author":"Robinson Jde","year":"2016","journal-title":"J Orthop Trauma"},{"issue":"5","key":"2024012714045216100_jbmr4461-bib-0023","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3109\/17453674.2012.729183","article-title":"Atypical femoral fracture following bisphosphonate treatment in a woman with osteogenesis imperfecta\u2014a case report","volume":"83","author":"Meier","year":"2012","journal-title":"Acta Orthop"},{"issue":"2","key":"2024012714045216100_jbmr4461-bib-0024","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jbmr.3299","article-title":"Evaluation of radius microstructure and areal bone mineral density improves fracture prediction in postmenopausal women","volume":"33","author":"Biver","year":"2018","journal-title":"J Bone Miner Res"},{"key":"2024012714045216100_jbmr4461-bib-0025","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group","volume":"843","year":"1994","journal-title":"World Health Organ Tech Rep Ser"},{"issue":"9","key":"2024012714045216100_jbmr4461-bib-0026","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","article-title":"Vertebral fracture assessment using a semiquantitative technique","volume":"8","author":"Genant","year":"1993","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024012714045216100_jbmr4461-bib-0027","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00198-012-2051-5","article-title":"Competing mortality and fracture risk assessment","volume":"24","author":"Leslie","year":"2013","journal-title":"Osteoporos Int"},{"key":"2024012714045216100_jbmr4461-bib-0028","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s11657-014-0187-y","article-title":"Epidemiology and economic burden of osteoporosis in Switzerland","volume":"9","author":"Svedbom","year":"2014","journal-title":"Arch Osteoporos"},{"issue":"3","key":"2024012714045216100_jbmr4461-bib-0029","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/joim.12586","article-title":"Excess mortality after hip fracture in elderly persons from Europe and the USA: the CHANCES project","volume":"281","author":"Katsoulis","year":"2017","journal-title":"J Intern Med"},{"issue":"10","key":"2024012714045216100_jbmr4461-bib-0030","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1007\/s00198-016-3616-5","article-title":"Hip fracture, mortality risk, and cause of death over two decades","volume":"27","author":"von Friesendorff","year":"2016","journal-title":"Osteoporos Int"},{"issue":"9","key":"2024012714045216100_jbmr4461-bib-0031","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s001980200100","article-title":"Survival and potential years of life lost after hip fracture in men and age-matched women","volume":"13","author":"Trombetti","year":"2002","journal-title":"Osteoporos Int"},{"issue":"8","key":"2024012714045216100_jbmr4461-bib-0032","doi-asserted-by":"crossref","first-page":"e10515","DOI":"10.1002\/jbm4.10515","article-title":"Incidence of atypical femoral fracture and its mortality in a Single Center in Singapore","volume":"5","author":"Gani","year":"2021","journal-title":"JBMR Plus"},{"issue":"11","key":"2024012714045216100_jbmr4461-bib-0033","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1007\/s00256-015-2212-7","article-title":"Bilateral atypical femoral fractures: how much symmetry is there on imaging?","volume":"44","author":"Probyn","year":"2015","journal-title":"Skeletal Radiol"},{"issue":"8","key":"2024012714045216100_jbmr4461-bib-0034","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s00198-014-2738-x","article-title":"Adherence to oral bisphosphonates and the risk of subtrochanteric and femoral shaft fractures among female Medicare beneficiaries","volume":"25","author":"Wang","year":"2014","journal-title":"Osteoporos Int"},{"issue":"2","key":"2024012714045216100_jbmr4461-bib-0035","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2106\/JBJS.20.00807","article-title":"Progression of asymptomatic contralateral femur in patients with complete atypical femoral fracture, according to initial radiographic findings","volume":"103","author":"Lee","year":"2021","journal-title":"J Bone Joint Surg Am"},{"key":"2024012714045216100_jbmr4461-bib-0036","first-page":"7","volume-title":"Paper presented at: American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting","author":"Dell","year":"2012"},{"issue":"6","key":"2024012714045216100_jbmr4461-bib-0037","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00198-018-4506-9","article-title":"A proposal for an atypical femur fracture treatment and prevention clinical practice guideline","volume":"29","author":"Dell","year":"2018","journal-title":"Osteoporos Int"},{"issue":"5","key":"2024012714045216100_jbmr4461-bib-0038","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/clinem\/dgz295","article-title":"Medical management of patients after atypical femur fractures: a systematic review and recommendations from the European Calcified Tissue Society","volume":"105","author":"van de Laarschot","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024012714045216100_jbmr4461-bib-0039","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1302\/0301-620X.99B3.BJJ-2016-0276.R2","article-title":"Atypical femoral fractures related to bisphosphonate treatment: issues and controversies related to their surgical management","volume":"99-B","author":"Koh","year":"2017","journal-title":"Bone Joint J"},{"issue":"4","key":"2024012714045216100_jbmr4461-bib-0040","doi-asserted-by":"crossref","first-page":"183","DOI":"10.11005\/jbm.2015.22.4.183","article-title":"Effect of teriparatide on healing of atypical femoral fractures: a systemic review","volume":"22","author":"Im","year":"2015","journal-title":"J Bone Metab"},{"issue":"5","key":"2024012714045216100_jbmr4461-bib-0041","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00774-014-0617-3","article-title":"Healing of bisphosphonate-associated atypical femoral fractures in patients with osteoporosis: a comparison between treatment with and without teriparatide","volume":"33","author":"Miyakoshi","year":"2015","journal-title":"J Bone Miner Metab"},{"key":"2024012714045216100_jbmr4461-bib-0042","doi-asserted-by":"crossref","first-page":"115033","DOI":"10.1016\/j.bone.2019.08.006","article-title":"A retrospective bicenter comparative study of surgical outcomes of atypical femoral fracture: potential effect of teriparatide on fracture healing and callus formation","volume":"128","author":"Shin","year":"2019","journal-title":"Bone"},{"issue":"11","key":"2024012714045216100_jbmr4461-bib-0043","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1007\/s00198-019-05131-2","article-title":"Different surgical outcomes in a patient with bilateral atypical femoral fracture related to bisphosphonate use with or without teriparatide treatment","volume":"30","author":"Zhang","year":"2019","journal-title":"Osteoporos Int"},{"issue":"Suppl 1","key":"2024012714045216100_jbmr4461-bib-0044","first-page":"23","article-title":"Teriparatide for the healing of\u00a0incomplete atypical femur fractures: the TAFF trial","volume":"35","author":"Tile","year":"2020","journal-title":"J Bone Miner\u00a0Res"},{"issue":"5","key":"2024012714045216100_jbmr4461-bib-0045","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.bone.2006.12.063","article-title":"Incidence of hip fracture over a 10-year period (1991-2000): reversal of a secular trend","volume":"40","author":"Chevalley","year":"2007","journal-title":"Bone"},{"issue":"1","key":"2024012714045216100_jbmr4461-bib-0046","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11657-020-00871-9","article-title":"SCOPE 2021: a new scorecard for osteoporosis in Europe","volume":"16","author":"Kanis","year":"2021","journal-title":"Arch Osteoporos"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/1\/87\/55459163\/jbmr4461.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/1\/87\/55459163\/jbmr4461.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:11Z","timestamp":1710328091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/1\/87-94\/7512192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,10,20]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4461","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4461\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4461\/v2\/review1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}