{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:40:27Z","timestamp":1783431627696,"version":"3.54.6"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["ZIA HG200407"],"award-info":[{"award-number":["ZIA HG200407"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK121326"],"award-info":[{"award-number":["R01 DK121326"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["ZIA HG200407"],"award-info":[{"award-number":["ZIA HG200407"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK121326"],"award-info":[{"award-number":["R01 DK121326"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Ectonucleotide pyrophosphatase\/phosphodiesterase 1 (ENPP1) deficiency leads to cardiovascular calcification in infancy, fibroblast growth factor 23 (FGF23)-mediated hypophosphatemic rickets in childhood, and osteomalacia in adulthood. Excessive enthesis mineralization and cervical spine fusion have been previously reported in patients with biallelic ENPP1 deficiency, but their effect on quality of life is unknown. We describe additional musculoskeletal complications in patients with ENPP1 deficiency, namely osteoarthritis and interosseous membrane ossification, and for the first time evaluate health-related quality of life (HRQoL) in patients with this disease, both subjectively via narrative report, and objectively via the Brief Pain Inventory\u2013Short Form, and a Patient Reported Outcome Measurement Information System Physical Function (PROMIS PF) short form. Residual pain, similar in magnitude to that identified in adult patients with X-linked hypophosphatemia, was experienced by the majority of patients despite use of analgesic medications. Impairment in physical function varied from mild to severe. To assess murine ENPP1 deficiency for the presence of enthesopathy, and for the potential response to enzyme replacement therapy, we maintained Enpp1asj\/asj mice on regular chow for 23\u2009weeks and treated cohorts with either vehicle or a long-acting form of recombinant ENPP1. Enpp1asj\/asj mice treated with vehicle exhibited robust calcification throughout their Achilles tendons, whereas two-thirds of those treated with ENPP1 enzyme replacement exhibited complete or partial suppression of the Achilles tendon calcification. Our combined results document that musculoskeletal complications are a significant source of morbidity in biallelic ENPP1 deficiency, a phenotype which is closely recapitulated in Enpp1asj\/asj mice. Finally, we show that a long-acting form of recombinant ENPP1 prevents the development of enthesis calcification at the relatively modest dose of 0.3\u2009mg\/kg per week, suggesting that suppression of enthesopathy may be attainable upon dose escalation. \u00a9 2021 American Society for Bone and Mineral Research (ASBMR). This article has been contributed to by US Government employees and their work is in the public domain in the USA.<\/jats:p>","DOI":"10.1002\/jbmr.4487","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T06:50:07Z","timestamp":1639032607000},"page":"494-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Musculoskeletal Comorbidities and Quality of Life in ENPP1-Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-1046","authenticated-orcid":false,"given":"Carlos R.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anenya Jai","family":"Ansh","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Nester","sequence":"additional","affiliation":[{"name":"Inozyme Pharma, Inc. Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"O'Brien","sequence":"additional","affiliation":[{"name":"GACI Global Argyle TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Stabach","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae-Il","family":"Murtada","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan R.","family":"Lester","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gus","family":"Khursigara","sequence":"additional","affiliation":[{"name":"Inozyme Pharma, Inc. Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Molloy","sequence":"additional","affiliation":[{"name":"GACI Global Argyle TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Endocrinology) Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0541-4689","authenticated-orcid":false,"given":"Demetrios T.","family":"Braddock","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"2024012714031301800_jbmr4487-bib-0001","author":"Ziegler"},{"key":"2024012714031301800_jbmr4487-bib-0002","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/s41436-020-00983-0","article-title":"Prospective phenotyping of long-term survivors of generalized arterial calcification of infancy (GACI)","volume":"23","author":"Ferreira","year":"2020","journal-title":"Genet Med"},{"issue":"4","key":"2024012714031301800_jbmr4487-bib-0003","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1089\/ten.teb.2018.0383","article-title":"Enthesis tissue engineering: biological requirements meet at the interface","volume":"25","author":"Calejo","year":"2019","journal-title":"Tissue Eng Part B Rev"},{"issue":"4","key":"2024012714031301800_jbmr4487-bib-0004","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bpj.2009.05.043","article-title":"Functional grading of mineral and collagen in the attachment of tendon to bone","volume":"97","author":"Genin","year":"2009","journal-title":"Biophys J"},{"issue":"56","key":"2024012714031301800_jbmr4487-bib-0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.actbio.2017.01.037","article-title":"Micro-mechanical properties of the tendon-to-bone attachment","volume":"1","author":"Deymier","year":"2017","journal-title":"Acta Biomater"},{"key":"2024012714031301800_jbmr4487-bib-0006","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.matbio.2016.01.016","article-title":"The role of bone sialoprotein in the tendon-bone insertion","volume":"52\u201354","author":"Marinovich","year":"2016","journal-title":"Matrix Biol"},{"issue":"1","key":"2024012714031301800_jbmr4487-bib-0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM198507043130101","article-title":"Calcification of entheses associated with X-linked hypophosphatemic osteomalacia","volume":"313","author":"Polisson","year":"1985","journal-title":"N Engl J Med"},{"issue":"3","key":"2024012714031301800_jbmr4487-bib-0008","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00223-009-9270-6","article-title":"Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice","volume":"85","author":"Liang","year":"2009","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0009","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.semarthrit.2012.12.019","article-title":"Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in Hyp mice","volume":"42","author":"Macica","year":"2013","journal-title":"Semin Arthritis Rheum"},{"issue":"Supplement 1","key":"2024012714031301800_jbmr4487-bib-0010","doi-asserted-by":"crossref","first-page":"SUN-364","DOI":"10.1210\/jendso\/bvaa046.960","article-title":"SUN-364 enthesophytes are a common feature of FGF23-mediated hypophosphatemia due to tumor-induced osteomalacia","volume":"4","author":"Gafni","year":"2020","journal-title":"J Endocr Soc"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0011","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1177\/2192568218801015","article-title":"Increase of the serum FGF-23 in ossification of the posterior longitudinal ligament","volume":"9","author":"Kawaguchi","year":"2019","journal-title":"Global Spine J"},{"issue":"10","key":"2024012714031301800_jbmr4487-bib-0012","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00264-010-1163-9","article-title":"Is ossification of posterior longitudinal ligament an enthesopathy?","volume":"35","author":"Chen","year":"2011","journal-title":"Int Orthop"},{"issue":"8","key":"2024012714031301800_jbmr4487-bib-0013","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.ekir.2019.05.004","article-title":"Description of 5 novel SLC34A3\/NPT2c mutations causing hereditary hypophosphatemic rickets with hypercalciuria","volume":"4","author":"Chen","year":"2019","journal-title":"Kidney Int Rep"},{"issue":"15","key":"2024012714031301800_jbmr4487-bib-0014","doi-asserted-by":"crossref","first-page":"dev163519","DOI":"10.1242\/dev.163519","article-title":"Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets","volume":"145","author":"Liu","year":"2018","journal-title":"Development"},{"issue":"4","key":"2024012714031301800_jbmr4487-bib-0015","doi-asserted-by":"crossref","first-page":"e1798","DOI":"10.1210\/clinem\/dgaa064","article-title":"Osteoarthritis, osteophytes, and enthesophytes affect biomechanical function in adults with X-linked hypophosphatemia","volume":"105","author":"Steele","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024012714031301800_jbmr4487-bib-0016","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-010-9373-0","article-title":"Phenotype presentation of hypophosphatemic rickets in adults","volume":"87","author":"Beck-Nielsen","year":"2010","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"2024012714031301800_jbmr4487-bib-0017","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1530\/EJE-15-0661","article-title":"Impaired quality of life in adults with X-linked hypophosphatemia and skeletal symptoms","volume":"174","author":"Che","year":"2016","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"2024012714031301800_jbmr4487-bib-0018","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1210\/en.2012-1551","article-title":"Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice","volume":"153","author":"Karaplis","year":"2012","journal-title":"Endocrinology"},{"issue":"10","key":"2024012714031301800_jbmr4487-bib-0019","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/JC.2015-2199","article-title":"Conventional therapy in adults with X-linked hypophosphatemia: effects on enthesopathy and dental disease","volume":"100","author":"Connor","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2024012714031301800_jbmr4487-bib-0020","doi-asserted-by":"crossref","first-page":"10006","DOI":"10.1038\/ncomms10006","article-title":"ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy","volume":"1","author":"Albright","year":"2015","journal-title":"Nat Commun"},{"issue":"10","key":"2024012714031301800_jbmr4487-bib-0021","doi-asserted-by":"crossref","first-page":"dmm035691","DOI":"10.1242\/dmm.035691","article-title":"ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy","volume":"11","author":"Khan","year":"2018","journal-title":"Dis Model Mech"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0022","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/jbmr.4254","article-title":"Response of the ENPP1-deficient skeletal phenotype to oral phosphate supplementation and\/or enzyme replacement therapy: comparative studies in humans and mice","volume":"36","author":"Ferreira","year":"2021","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024012714031301800_jbmr4487-bib-0023","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland","year":"1994","journal-title":"Ann Acad Med Singapore"},{"issue":"2","key":"2024012714031301800_jbmr4487-bib-0024","first-page":"605","article-title":"Patient-reported outcomes measurement information system and legacy patient-reported outcome measures in the field of orthopaedics: a systematic review","volume":"34","author":"Fidai","year":"2018","journal-title":"Art Ther"},{"issue":"3","key":"2024012714031301800_jbmr4487-bib-0025","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s11136-017-1709-z","article-title":"Establishing clinical severity for PROMIS\u00ae measures in adult patients with rheumatic diseases","volume":"27","author":"Nagaraja","year":"2018","journal-title":"Qual Life Res"},{"issue":"1","key":"2024012714031301800_jbmr4487-bib-0026","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/cts.12887","article-title":"Improving the pharmacodynamics and in vivo activity of ENPP1-fc through protein and glycosylation engineering","volume":"14","author":"Stabach","year":"2021","journal-title":"Clin Transl Sci"},{"issue":"3","key":"2024012714031301800_jbmr4487-bib-0027","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jbmr.3911","article-title":"Human heterozygous ENPP1 deficiency is associated with early onset osteoporosis, a phenotype recapitulated in a mouse model of Enpp1 deficiency","volume":"35","author":"Oheim","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024012714031301800_jbmr4487-bib-0028","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jbmr.3938","article-title":"Clinical and biochemical phenotypes in a family with ENPP1 mutations","volume":"35","author":"Kotwal","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2024012714031301800_jbmr4487-bib-0029","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0030","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1161\/HYPERTENSIONAHA.115.06262","article-title":"Excessive adventitial remodeling leads to early aortic maladaptation in angiotensin-induced hypertension","volume":"67","author":"Bersi","year":"2016","journal-title":"Hypertension"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0031","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/ajmg.a.37574","article-title":"Treatment of hypophosphatemic rickets in generalized arterial calcification of infancy (GACI) without worsening of vascular calcification","volume":"170A","author":"Ferreira","year":"2016","journal-title":"Am J Med Genet A"},{"key":"2024012714031301800_jbmr4487-bib-0032"},{"issue":"8","key":"2024012714031301800_jbmr4487-bib-0033","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.jval.2018.01.013","article-title":"Qualitative research to explore the patient experience of X-linked hypophosphatemia and evaluate the suitability of the BPI-SF and WOMAC\u00ae as clinical trial end points","volume":"21","author":"Theodore-Oklota","year":"2018","journal-title":"Value Health"},{"issue":"12","key":"2024012714031301800_jbmr4487-bib-0034","doi-asserted-by":"crossref","first-page":"bvaa151","DOI":"10.1210\/jendso\/bvaa151","article-title":"X-linked hypophosphatemia: a new era in management","volume":"4","author":"Dahir","year":"2020","journal-title":"J Endocr Soc"},{"issue":"1","key":"2024012714031301800_jbmr4487-bib-0035","first-page":"S336","article-title":"Efficacy and safety of KRN23 in adults with X-linked hypophosphatemia (XLH): data from a phase 2 extension study","volume":"28","author":"Carpenter","year":"2017","journal-title":"Osteoporos Int"},{"issue":"7","key":"2024012714031301800_jbmr4487-bib-0036","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1210\/js.2018-00365","article-title":"The lifelong impact of X-linked hypophosphatemia: results from a burden of disease survey","volume":"3","author":"Skrinar","year":"2019","journal-title":"J Endocr Soc"},{"key":"2024012714031301800_jbmr4487-bib-0037","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bone.2015.05.040","article-title":"Clinical and molecular heterogeneity in a large series of patients with hypophosphatemic rickets","volume":"79","author":"Capelli","year":"2015","journal-title":"Bone"},{"issue":"2","key":"2024012714031301800_jbmr4487-bib-0038","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1210\/endo-111-2-650","article-title":"Secondary hyperparathyroidism in X-linked hypophosphatemic mice","volume":"111","author":"Kiebzak","year":"1982","journal-title":"Endocrinology"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0039","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00467-004-1443-y","article-title":"The enigma of hyperparathyroidism in hypophosphatemic rickets","volume":"19","author":"Schmitt","year":"2004","journal-title":"Pediatr Nephrol"},{"issue":"3","key":"2024012714031301800_jbmr4487-bib-0040","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00223-019-00568-3","article-title":"Continued beneficial effects of burosumab in adults with X-linked hypophosphatemia: results from a 24-week treatment continuation period after a 24-week double-blind placebo-controlled period","volume":"105","author":"Portale","year":"2019","journal-title":"Calcif Tissue Int"},{"key":"2024012714031301800_jbmr4487-bib-0041","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1038\/s41436-021-01228-4","article-title":"Correspondence on \u201cProspective phenotyping of long-term survivors of generalized arterial calcification of infancy (GACI)\u201d by Ferreira et al.","volume":"23","author":"Stern","year":"2021","journal-title":"Genet Med"},{"key":"2024012714031301800_jbmr4487-bib-0042","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/s41436-021-01229-3","article-title":"Response to Stern","volume":"23","author":"Ziegler","year":"2021","journal-title":"Genet Med"},{"issue":"7","key":"2024012714031301800_jbmr4487-bib-0043","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3899\/jrheum.190512","article-title":"Imaging techniques: options for the diagnosis and monitoring of treatment of enthesitis in psoriatic arthritis","volume":"47","author":"Bakewell","year":"2020","journal-title":"J Rheumatol"},{"issue":"5","key":"2024012714031301800_jbmr4487-bib-0044","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3899\/jrheum.160387","article-title":"Performance of 3 Enthesitis indices in patients with peripheral spondyloarthritis during treatment with adalimumab","volume":"44","author":"Mease","year":"2017","journal-title":"J Rheumatol"},{"issue":"2","key":"2024012714031301800_jbmr4487-bib-0045","doi-asserted-by":"crossref","first-page":"176","DOI":"10.17294\/2330-0698.1727","article-title":"Giving credence to the experience of X-linked hypophosphatemia in adulthood: an interprofessional mixed-methods study","volume":"7","author":"Hughes","year":"2020","journal-title":"J Patient Cent Res Rev"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4487","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4487","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/3\/494\/55457972\/jbmr4487.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/3\/494\/55457972\/jbmr4487.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:21Z","timestamp":1710328101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/3\/494-504\/7516703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,12,9]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4487","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4487\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4487\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4487\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4487\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4487\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4487\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4487\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}