{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:51:58Z","timestamp":1790632318108,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":440,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Development Project of Nanjing Science and Technology Commission and Foundation","award":["ZKX20020"],"award-info":[{"award-number":["ZKX20020"]}]},{"name":"Jiangsu Provincial Key Medical Center funds","award":["YXZXA2016009"],"award-info":[{"award-number":["YXZXA2016009"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772422"],"award-info":[{"award-number":["81772422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772422"],"award-info":[{"award-number":["81772422"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory skeletal disease characterized by the progressive ectopic ossification and calcification of ligaments and enthuses. However, specific pathogenesis remains unknown. Bone marrow mesenchymal stem cells (BMSCs) are a major source of osteoblasts and play vital roles in bone metabolism and ectopic osteogenesis. However, it is unclear whether BMSCs are involved in ectopic calcification and ossification in DISH. The current study aimed to explore the osteogenic differentiation abilities of BMSCs from DISH patients (DISH-BMSCs). Our results showed that DISH-BMSCs exhibited stronger osteogenic differentiation abilities than normal control (NC)-BMSCs. Human cytokine array kit analysis showed significantly increased secretion of Galectin-3 in DISH-BMSCs. Furthermore, Galectin-3 downregulation inhibited the increased osteogenic differentiation ability of DISH-BMSCs, whereas exogenous Galectin-3 significantly enhanced the osteogenic differentiation ability of NC-BMSCs. Notably, the increased Galectin-3 in DISH-BMSCs enhanced the expression of \u03b2-catenin as well as TCF-4, whereas attenuation of Wnt\/\u03b2-catenin signaling partially alleviated Galectin-3-induced osteogenic differentiation and activity in DISH-BMSCs. In addition, our results noted that Galectin-3 interacted with \u03b2-catenin and enhanced its nuclear accumulation. Further in vivo studies showed that exogenous Galectin-3 enhanced ectopic bone formation in the Achilles tendon in trauma-induced rats by activating Wnt\/\u03b2-catenin signaling. The current study indicated that enhanced osteogenic differentiation of DISH-BMSCs was mainly attributed to the increased secretion of Galectin-3 by DISH-BMSCs, which enhanced \u03b2-catenin expression and its nuclear accumulation. Our study helps illuminate the mechanisms of pathological osteogenesis and sheds light on the possible development of potential therapeutic strategies for DISH treatment. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4508","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T08:49:26Z","timestamp":1642841366000},"page":"724-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Galectin-3 Enhances Osteogenic Differentiation of Precursor Cells From Patients With Diffuse Idiopathic Skeletal Hyperostosis via Wnt\/\u03b2-Catenin Signaling"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6120-4216","authenticated-orcid":false,"given":"Liang","family":"Xu","sequence":"first","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7553-0637","authenticated-orcid":false,"given":"Zhuang","family":"Qian","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinian","family":"Wang","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Pu","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshuang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changzhi","family":"Du","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanchi","family":"Chen","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Feng","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilei","family":"Xu","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Sun","sequence":"additional","affiliation":[{"name":"Spine Surgery, Affiliated Drum Tower Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"issue":"7","key":"2024012714021806300_jbmr4508-bib-0001","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1093\/rheumatology\/kex056","article-title":"Classification criteria for diffuse idiopathic skeletal hyperostosis: a lack of consensus","volume":"56","author":"Kuperus","year":"2017","journal-title":"Rheumatology."},{"issue":"12","key":"2024012714021806300_jbmr4508-bib-0002","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrrheum.2013.165","article-title":"Diffuse idiopathic skeletal hyperostosis: clinical features and pathogenic mechanisms","volume":"9","author":"Mader","year":"2013","journal-title":"Nat Rev Rheumatol."},{"issue":"7","key":"2024012714021806300_jbmr4508-bib-0003","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/art.40465","article-title":"Diffuse idiopathic skeletal hyperostosis-on the wrong side?","volume":"70","author":"Martens","year":"2018","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"2024012714021806300_jbmr4508-bib-0004","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jbspin.2013.02.011","article-title":"Diffuse idiopathic skeletal hyperostosis (Forestier-Rotes-Querol disease): what's new?","volume":"80","author":"Mazi\u00e8res","year":"2013","journal-title":"Joint Bone Spine"},{"issue":"10","key":"2024012714021806300_jbmr4508-bib-0005","first-page":"1635","article-title":"Is diffuse idiopathic skeletal hyperostosis a disease or a syndrome?","volume":"56","author":"Pappone","year":"2017","journal-title":"Rheumatology"},{"issue":"2","key":"2024012714021806300_jbmr4508-bib-0006","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1148\/radiol.2019181695","article-title":"Criteria for early-phase diffuse idiopathic skeletal hyperostosis: development and validation","volume":"291","author":"Kuperus","year":"2019","journal-title":"Radiology."},{"key":"2024012714021806300_jbmr4508-bib-0007","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41413-020-0091-6","article-title":"Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH)","volume":"8","author":"Fournier","year":"2020","journal-title":"Bone Res."},{"issue":"1","key":"2024012714021806300_jbmr4508-bib-0008","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jor.23267","article-title":"Histological characteristics of diffuse idiopathic skeletal hyperostosis","volume":"35","author":"Kuperus","year":"2017","journal-title":"J Orthop Res."},{"issue":"1","key":"2024012714021806300_jbmr4508-bib-0009","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/molecules23010095","article-title":"The impact of lipid types and liposomal formulations on osteoblast adiposity and mineralization","volume":"23","author":"Chang","year":"2018","journal-title":"Molecules"},{"issue":"7","key":"2024012714021806300_jbmr4508-bib-0010","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ."},{"issue":"11","key":"2024012714021806300_jbmr4508-bib-0011","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41419-019-1949-7","article-title":"SPRY4 is responsible for pathogenesis of adolescent idiopathic scoliosis by contributing to osteogenic differentiation and melatonin response of bone marrow-derived mesenchymal stem cells","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"issue":"2","key":"2024012714021806300_jbmr4508-bib-0012","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/art.39433","article-title":"Imbalance between bone morphogenetic protein 2 and noggin induces abnormal osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis","volume":"68","author":"Xie","year":"2016","journal-title":"Arthritis Rheumatol."},{"issue":"5","key":"2024012714021806300_jbmr4508-bib-0013","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41419-019-1586-1","article-title":"Enhanced osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis: a study based on a three-dimensional biomimetic environment","volume":"10","author":"Zheng","year":"2019","journal-title":"Cell Death Dis"},{"issue":"12","key":"2024012714021806300_jbmr4508-bib-0014","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1172\/JCI125212","article-title":"HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis","volume":"129","author":"Liu","year":"2019","journal-title":"J Clin Invest."},{"key":"2024012714021806300_jbmr4508-bib-0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.metabol.2018.02.001","article-title":"Galectin-3 is essential for proper bone cell differentiation and activity, bone remodeling and biomechanical competence in mice","volume":"83","author":"Iacobini","year":"2018","journal-title":"Metabolism."},{"issue":"1","key":"2024012714021806300_jbmr4508-bib-0016","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1038\/s41467-019-11441-0","article-title":"Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease","volume":"10","author":"Siew","year":"2019","journal-title":"Nat Commun"},{"issue":"18","key":"2024012714021806300_jbmr4508-bib-0017","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/CIRCULATIONAHA.118.035047","article-title":"IL (interleukin)-10-STAT3-Galectin-3 axis is essential for osteopontin-producing reparative macrophage polarization after myocardial infarction","volume":"138","author":"Shirakawa","year":"2018","journal-title":"Circulation."},{"issue":"11","key":"2024012714021806300_jbmr4508-bib-0018","doi-asserted-by":"crossref","first-page":"e004360","DOI":"10.1161\/JAHA.116.004360","article-title":"Role for Galectin-3 in calcific aortic valve stenosis","volume":"5","author":"S\u00e1daba","year":"2016","journal-title":"J Am Heart Assoc"},{"issue":"19","key":"2024012714021806300_jbmr4508-bib-0019","doi-asserted-by":"crossref","first-page":"17360","DOI":"10.1074\/jbc.M207631200","article-title":"Expression of Galectin-3 in skeletal tissues is controlled by Runx2","volume":"278","author":"Stock","year":"2003","journal-title":"J Biol Chem."},{"issue":"1","key":"2024012714021806300_jbmr4508-bib-0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.18632\/aging.100865","article-title":"Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles","volume":"8","author":"Weilner","year":"2016","journal-title":"Aging."},{"issue":"7","key":"2024012714021806300_jbmr4508-bib-0021","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1073\/pnas.97.7.3213","article-title":"Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow","volume":"97","author":"Colter","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2024012714021806300_jbmr4508-bib-0022","article-title":"PLC\u03b5 knockdown overcomes drug resistance to androgen receptor antagonist in castration-resistant prostate cancer by suppressing the wnt3a\/\u03b2-catenin pathway","author":"Li","year":"2019","journal-title":"J Cell Physiol."},{"issue":"9","key":"2024012714021806300_jbmr4508-bib-0023","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nchembio.1309","article-title":"Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5\/6 interaction","volume":"9","author":"Wang","year":"2013","journal-title":"Nat Chem Biol."},{"issue":"1","key":"2024012714021806300_jbmr4508-bib-0024","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41467-018-02988-5","article-title":"Inhibition of overactive TGF-\u03b2 attenuates progression of heterotopic ossification in mice","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun"},{"issue":"4","key":"2024012714021806300_jbmr4508-bib-0025","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nm.2334","article-title":"Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor-\u03b3 agonists","volume":"17","author":"Shimono","year":"2011","journal-title":"Nat Med."},{"issue":"4","key":"2024012714021806300_jbmr4508-bib-0026","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1158\/0008-5472.CAN-08-4153","article-title":"Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity","volume":"69","author":"Song","year":"2009","journal-title":"Cancer Res"},{"issue":"11","key":"2024012714021806300_jbmr4508-bib-0027","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neo.2014.09.005","article-title":"Galectin-3 inhibits osteoblast differentiation through notch signaling","volume":"16","author":"Nakajima","year":"2014","journal-title":"Neoplasia."},{"key":"2024012714021806300_jbmr4508-bib-0028","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biocel.2016.05.015","article-title":"The role of the wnt\/\u03b2-catenin signaling pathway in formation and maintenance of bone and teeth","volume":"77","author":"Duan","year":"2016","journal-title":"Int J Biochem Cell Biol."},{"issue":"1","key":"2024012714021806300_jbmr4508-bib-0029","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/nrrheum.2011.189","article-title":"Bone: exploring factors responsible for bone formation in DISH","volume":"8","author":"Mader","year":"2011","journal-title":"Nat Rev Rheumatol."},{"issue":"11","key":"2024012714021806300_jbmr4508-bib-0030","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/biom9110711","article-title":"Fermented oyster extract promotes osteoblast differentiation by activating the Wnt\/\u03b2-catenin signaling pathway, leading to Bone formation","volume":"9","author":"Molagoda","year":"2019","journal-title":"Biomolecules"},{"key":"2024012714021806300_jbmr4508-bib-0031","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3389\/fphar.2019.01308","article-title":"Wnt\/\u03b2-catenin pathway-regulated fibromodulin expression is crucial for breast cancer metastasis and inhibited by aspirin","volume":"10","author":"Khan","year":"2019","journal-title":"Front Pharmacol."},{"issue":"Suppl","key":"2024012714021806300_jbmr4508-bib-0032","first-page":"157","article-title":"A new breed of mouse showing multiple osteochondral lesions-twy mouse","volume":"21","author":"Hosoda","year":"1981","journal-title":"Ryumachi."},{"issue":"2","key":"2024012714021806300_jbmr4508-bib-0033","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00296345","article-title":"Elevation of alkaline phosphatase activity induced by parathyroid hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY (twy\/twy)","volume":"56","author":"Terakado","year":"1995","journal-title":"Calcif Tissue Int."},{"issue":"2","key":"2024012714021806300_jbmr4508-bib-0034","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-015-0068-4","article-title":"Teriparatide improves trabecular osteoporosis but simultaneously promotes ankylosis of the spine in the Twy mouse model for diffuse idiopathic skeletal hyperostosis","volume":"98","author":"Hamano","year":"2016","journal-title":"Calcif Tissue Int."},{"issue":"5","key":"2024012714021806300_jbmr4508-bib-0035","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/jbmr.1826","article-title":"Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans","volume":"28","author":"Warraich","year":"2013","journal-title":"J Bone Miner Res."},{"key":"2024012714021806300_jbmr4508-bib-0036","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bone.2016.05.008","article-title":"Disruption of biomineralization pathways in spinal tissues of a mouse model of diffuse idiopathic skeletal hyperostosis","volume":"90","author":"Ii","year":"2016","journal-title":"Bone."},{"issue":"5","key":"2024012714021806300_jbmr4508-bib-0037","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1097\/CORR.0000000000001085","article-title":"Heterotopic ossification after an Achilles tendon rupture cannot be prevented by early functional rehabilitation: a cohort study","volume":"478","author":"Magnusson","year":"2020","journal-title":"Clin Orthop Relat Res."},{"issue":"6","key":"2024012714021806300_jbmr4508-bib-0038","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1097\/PRS.0000000000001266","article-title":"Role of gender in burn-induced heterotopic ossification and mesenchymal cell osteogenic differentiation","volume":"135","author":"Ranganathan","year":"2015","journal-title":"Plast Reconstr Surg."},{"key":"2024012714021806300_jbmr4508-bib-0039","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bone.2017.06.014","article-title":"Gli1-labeled adult mesenchymal stem\/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification","volume":"109","author":"Kan","year":"2018","journal-title":"Bone."},{"issue":"6","key":"2024012714021806300_jbmr4508-bib-0040","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/stem.2991","article-title":"Coordinating tissue regeneration through transforming growth factor-\u03b2 activated kinase 1 inactivation and reactivation","volume":"37","author":"Hsieh","year":"2019","journal-title":"Stem Cell."},{"key":"2024012714021806300_jbmr4508-bib-0041","doi-asserted-by":"crossref","first-page":"114113","DOI":"10.1016\/j.bcp.2020.114113","article-title":"Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression","volume":"178","author":"Wang","year":"2020","journal-title":"Biochem Pharmacol."},{"issue":"3","key":"2024012714021806300_jbmr4508-bib-0042","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1161\/HYPERTENSIONAHA.118.11874","article-title":"CT-1 (Cardiotrophin-1)-Gal-3 (Galectin-3) axis in cardiac fibrosis and inflammation","volume":"73","author":"Mart\u00ednez-Mart\u00ednez","year":"2019","journal-title":"Hypertension."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4508","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/4\/724\/55458708\/jbmr4508.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/4\/724\/55458708\/jbmr4508.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:30Z","timestamp":1710328110000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/4\/724-739\/7516758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,1,22]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4508","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4508\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4508\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}