{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:38:55Z","timestamp":1790699935914,"version":"4.1.0"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":441,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIH\/NIAMS","doi-asserted-by":"publisher","award":["1K01AR064314- 01"],"award-info":[{"award-number":["1K01AR064314- 01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIH\/NIAMS","doi-asserted-by":"publisher","award":["R21AR073454"],"award-info":[{"award-number":["R21AR073454"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIH\/NIA","doi-asserted-by":"publisher","award":["R01AG067997"],"award-info":[{"award-number":["R01AG067997"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["1K01AR064314\u2010 01"],"award-info":[{"award-number":["1K01AR064314\u2010 01"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21AR073454"],"award-info":[{"award-number":["R21AR073454"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG067997"],"award-info":[{"award-number":["R01AG067997"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fracture despite exhibiting normal to high bone mineral density (BMD). Conditions arising from T2DM, such as reduced bone turnover and alterations in microarchitecture, may contribute to skeletal fragility by influencing bone morphology and microdamage accumulation. The objectives of this study were (i) to characterize the effect of T2DM on microdamage quantity and morphology in cancellous bone, and (ii) relate the accumulation of microdamage to the cancellous microarchitecture. Cancellous specimens from the femoral neck were collected during total hip arthroplasty (T2DM: n\u00a0=\u200922, age\u00a0=\u00a065\u2009\u00b1\u20099\u2009years, glycated hemoglobin [HbA1c]\u00a0=\u00a07.00%\u2009\u00b1\u20090.98%; non-diabetic [non-DM]: n\u00a0=\u200925, age\u00a0=\u00a061\u2009\u00b1\u20098\u2009years, HbA1c\u00a0=\u00a05.50%\u2009\u00b1\u20090.4%), compressed to 3% strain, stained with lead uranyl acetate to isolate microdamage, and scanned with micro\u2013computed tomography (\u03bcCT). Individual trabeculae segmentation was used to isolate rod-like and plate-like trabeculae and their orientations with respect to the loading axis. The T2DM group trended toward a greater BV\/TV (+27%, p\u00a0=\u20090.07) and had a more plate-like trabecular architecture (+8% BVplates, p\u00a0=\u20090.046) versus non-DM specimens. Rods were more damaged relative to their volume compared to plates in the non-DM group (DVrods\/BVrods versus DVplates\/BVplates: +49%, p\u00a0&amp;lt;\u20090.0001), but this difference was absent in T2DM specimens. Longitudinal rods were more damaged in the non-DM group (DVlongitudinal rods\/BVlongitudinal rods: +73% non-DM versus T2DM, p\u00a0=\u20090.027). Total damage accumulation (DV\/BV) and morphology (DS\/DV) did not differ in T2DM versus non-DM specimens. These results provide evidence that cancellous microarchitecture does not explain fracture risk in T2DM, pointing to alterations in material matrix properties. In particular, cancellous bone from men with T2DM may have an attenuated ability to mitigate microdamage accumulation through sacrificial rods. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>\n                  <jats:p>Abstract<\/jats:p>\n                  <jats:p>Reconstructions of representative T2DM cancellous specimen with highlighted plate microdamage (green) and rod microdamage (red). Rods were more damaged relative to their volume vs. plates in non-DM specimens but this difference was absent in T2DM specimens.<\/jats:p>","DOI":"10.1002\/jbmr.4509","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T08:53:35Z","timestamp":1642841615000},"page":"740-752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8410-1500","authenticated-orcid":false,"given":"Sara E.","family":"Sacher","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Cornell University Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather B.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Cornell University Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashank","family":"Lekkala","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Cornell University Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsie A.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Cornell University Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Potts","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Cornell University Ithaca NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison K.","family":"Heilbronner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology and Metabolic Bone Service Hospital for Special Surgery New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-5774","authenticated-orcid":false,"given":"Emily M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Medicine, Endocrinology and Metabolic Bone Service Hospital for Special Surgery New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-6533","authenticated-orcid":false,"given":"Christopher J.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Sibley School of Mechanical and Aerospace Engineering Cornell University Ithaca NY USA"},{"name":"Research Division Hospital for Special Surgery New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8165-9568","authenticated-orcid":false,"given":"Eve","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Research Division Hospital for Special Surgery New York NY 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