{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:27:57Z","timestamp":1789421277552,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":447,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Hsinchu Mackay Memorial Hospital","award":["MMH-104-06"],"award-info":[{"award-number":["MMH-104-06"]}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Exclusively breastfed infants are at a high risk of vitamin D deficiency. Few studies have evaluated the effects of vitamin D supplementation. Hence, we conducted a prospective randomized controlled trial investigating the effects of oral vitamin D3 400 IU\/d supplementation in exclusively breastfed newborns. Serum 25-hydroxy-vitamin D (25[OH]D) levels in pregnant women and their newborns were evaluated. Breastfed newborns were randomized to one of two regimens at age 10\u2009days. One group received vitamin D3 supplementation at a dose of 400\u2009IU\/d (vD-400 group), whereas the placebo group received a liquid product without vitamin D3. Outcomes were assessed at 4\u00a0months of age. A total of 92 pregnant women and their infants were enrolled, and the data of 72 infants (37 in the vD-400 group and 35 in the placebo group) who completed the study at 4\u2009months of age were assessed. The results showed severe vitamin D deficiency in 15.2% of mothers before delivery, while 54.3% had vitamin D deficiency. Moreover, 15.2% of newborns presented with severe vitamin D deficiency at birth, while 52.2% had vitamin D deficiency. Maternal vitamin D levels were significantly correlated with infant vitamin D levels at birth (r\u00a0=\u00a00.816, p\u2009&amp;lt;\u20090.001). At 4\u2009months of age, weight, head circumference, serum 25(OH)D, phosphorus, and intact parathyroid hormone levels significantly differed between the vD-400 and placebo groups. However, the body length and bone mineral density of the two groups did not differ significantly. Regardless of vitamin D supplementation, participants with severe vitamin D deficiency had significantly higher intact parathyroid hormone levels and lower bone mineral content. In conclusion, among exclusively breastfed infants, oral supplementation with vitamin D3 at a dose of 400\u2009IU\/d from age 10\u2009days increased 25(OH)D concentrations at 4\u2009months of age, but it did not affect bone mineralization. \u00a9 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4521","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T09:59:56Z","timestamp":1644055196000},"page":"786-793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of Oral Vitamin D3 Supplementation in Exclusively Breastfed Newborns: Prospective, Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-0907","authenticated-orcid":false,"given":"Chao-Hsu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medicine MacKay Medical College New Taipei Taiwan"},{"name":"Department of Biological Science and Technology National Yang Ming Chiao Tung University Hsinchu Taiwan"},{"name":"Department of Pediatrics Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine MacKay Medical College New Taipei Taiwan"},{"name":"Department of Pediatrics Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsiang","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Tse","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun-Long","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing-Jyh","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hsinchu MacKay Memorial Hospital Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics MacKay Children's Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann-Jinn","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences MacKay Medical College New Taipei Taiwan"},{"name":"Department of Pediatrics, School of Medicine, College of Medicine Taipei Medical University Taipei Taiwan"},{"name":"Department of Medical Research Tamsui MacKay Memorial Hospital New Taipei Taiwan"},{"name":"Department of Pediatrics MacKay Children's Hospital Taipei Taiwan"},{"name":"Department of Medicine MacKay Medical College New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hsin","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Pediatrics MacKay Children's Hospital Taipei Taiwan"},{"name":"Department of Medicine MacKay Medical College New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics MacKay Children's Hospital Taipei Taiwan"},{"name":"Department of Medicine MacKay Medical College New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Changhua Christian 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