{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:15:23Z","timestamp":1791728123509,"version":"4.3.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":483,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AR070241"],"award-info":[{"award-number":["K01 AR070241"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG004875"],"award-info":[{"award-number":["P01 AG004875"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG062413"],"award-info":[{"award-number":["P01 AG062413"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG048792"],"award-info":[{"award-number":["R01 AG048792"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR068275"],"award-info":[{"award-number":["R01 AR068275"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK128552"],"award-info":[{"award-number":["R01 DK128552"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K01 AR070241"],"award-info":[{"award-number":["K01 AR070241"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG004875"],"award-info":[{"award-number":["P01 AG004875"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG062413"],"award-info":[{"award-number":["P01 AG062413"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG048792"],"award-info":[{"award-number":["R01 AG048792"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR068275"],"award-info":[{"award-number":["R01 AR068275"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK128552"],"award-info":[{"award-number":["R01 DK128552"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oxidative stress-induced reactive oxygen species, DNA damage, apoptosis, and cellular senescence have been associated with reduced osteoprogenitors in a reciprocal fashion to bone marrow adipocyte tissue (BMAT); however, a direct (causal) link between cellular senescence and BMAT is still elusive. Accumulation of senescent cells occur in naturally aged and in focally radiated bone tissue, but despite amelioration of age- and radiation-associated bone loss after senescent cell clearance, molecular events that precede BMAT accrual are largely unknown. Here we show by RNA-Sequencing data that BMAT-related genes were the most upregulated gene subset in radiated bones of C57BL\/6 mice. Using focal radiation as a model to understand age-associated changes in bone, we performed a longitudinal assessment of cellular senescence and BMAT. Using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR), RNA in situ hybridization of p21 transcripts and histological assessment of telomere dysfunction as a marker of senescence, we observed an increase in senescent cell burden of bone cells from day 1 postradiation, without the presence of BMAT. BMAT was significantly elevated in radiated bones at day 7, confirming the qRT-PCR data in which most BMAT-related genes were elevated by day 7, and the trend continued until day 42 postradiation. Similarly, elevation in BMAT-related genes was observed in bones of aged mice. The senolytic cocktail of Dasatinib (D) plus Quercetin (Q) (ie, D\u2009+\u2009Q), which clears senescent cells, reduced BMAT in aged and radiated bones. MicroRNAs (miRNAs or miRs) linked with senescence marker p21 were downregulated in radiated and aged bones, whereas miR-27a, a miR that is associated with increased BMAT, was elevated both in radiated and aged bones. D\u2009+\u2009Q downregulated miR-27a in radiated bones at 42\u2009days postradiation. Overall, our study provides evidence that BMAT occurrence in oxidatively stressed bone environments, such as radiation and aging, is induced following a common pathway and is dependent on the presence of senescent cells. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>\n                  <jats:p>Abstract<\/jats:p>\n                  <jats:p>Schematic representing a senescent bone environment during aging and radiation. The schematic represents changes in an oxidatively stressed, senescent microenvironment in which mesenchymal progenitors are preferentially forming adipocytes, regulated by a common process shared between aging bone and radiation-induced bone damage, and with identical expression patterns of bone marrow adipocyte tissue (BMAT)-related genes and microRNAs (miRNAs or miRs). Increase in senescent markers p21 and p16Ink4a induce a cellular state in which production of the senescence-associated secretory phenotype (SASP) increases and influences the bone marrow environment. Secreted adipokines can promote mesenchymal stem cell (MSC) fate, switching to an adipocyte lineage. Several adipokines are also released in circulation, causing systemic effects. These changes in senescence markers and genes that regulate BMAT are in turn regulated by their corresponding miRNAs. These changes can be blocked or reversed by the clearance of senescent cells using senolytic drugs. The figure was created with BioRender.com.<\/jats:p>","DOI":"10.1002\/jbmr.4537","type":"journal-article","created":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:11:02Z","timestamp":1646482262000},"page":"997-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Bone Marrow Adiposity in Models of Radiation- and Aging-Related Bone Loss Is Dependent on Cellular Senescence"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-9669","authenticated-orcid":false,"given":"Abhishek","family":"Chandra","sequence":"first","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Medicine Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony B.","family":"Lagnado","sequence":"additional","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-6414","authenticated-orcid":false,"given":"Joshua N.","family":"Farr","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Schleusner","sequence":"additional","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4818-0114","authenticated-orcid":false,"given":"David G.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0673-3710","authenticated-orcid":false,"given":"Dominik","family":"Saul","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-1890","authenticated-orcid":false,"given":"Jo\u00e3o F.","family":"Passos","sequence":"additional","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Medicine Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-4372","authenticated-orcid":false,"given":"Sundeep","family":"Khosla","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-9438","authenticated-orcid":false,"given":"Robert J.","family":"Pignolo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Medicine Mayo Clinic College of Medicine Rochester MN USA"},{"name":"Department of Physiology and Biomedical Engineering Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,5]]},"reference":[{"key":"2024012714000082200_jbmr4537-bib-0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-72228-3_1","volume-title":"Fractures in the Elderly: A Guide to Practical Management","author":"Chandra","year":"2018"},{"key":"2024012714000082200_jbmr4537-bib-0002","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/joim.12718","article-title":"Clinical implications of bone marrow adiposity","volume":"283","author":"Veldhuis-Vlug","year":"2018","journal-title":"J Intern Med"},{"key":"2024012714000082200_jbmr4537-bib-0003","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2213-8587(14)70007-5","article-title":"The bone-fat interface: basic and clinical implications of marrow adiposity","volume":"3","author":"Devlin","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2024012714000082200_jbmr4537-bib-0004","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jbmr.3895","article-title":"Greater bone marrow adiposity predicts bone loss in older women","volume":"35","author":"Woods","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2024012714000082200_jbmr4537-bib-0005","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jbmr.2996","article-title":"Suppression of sclerostin alleviates radiation-induced bone loss by protecting bone-forming cells and their progenitors through distinct mechanisms","volume":"32","author":"Chandra","year":"2017","journal-title":"J Bone Miner Res"},{"key":"2024012714000082200_jbmr4537-bib-0006","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54695","article-title":"Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment","volume":"9","author":"Zhong","year":"2020","journal-title":"Elife"},{"key":"2024012714000082200_jbmr4537-bib-0007","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bone.2016.01.014","article-title":"Aging alters bone-fat reciprocity by shifting in vivo mesenchymal precursor cell fate towards an adipogenic lineage","volume":"85","author":"Singh","year":"2016","journal-title":"Bone"},{"key":"2024012714000082200_jbmr4537-bib-0008","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s40610-018-0096-8","article-title":"Molecular interaction of bone marrow adipose tissue with energy metabolism","volume":"4","author":"Suchacki","year":"2018","journal-title":"Curr Mol Biol Rep"},{"key":"2024012714000082200_jbmr4537-bib-0009","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","article-title":"The limited in vitro lifetime of human diploid cell strains","volume":"37","author":"Hayflick","year":"1965","journal-title":"Exp Cell Res"},{"key":"2024012714000082200_jbmr4537-bib-0010","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Coppe","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"2024012714000082200_jbmr4537-bib-0011","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/jbmr.3978","article-title":"Targeted reduction of senescent cell burden alleviates focal radiotherapy-related bone loss","volume":"35","author":"Chandra","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2024012714000082200_jbmr4537-bib-0012","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/jbmr.2892","article-title":"Identification of senescent cells in the bone microenvironment","volume":"31","author":"Farr","year":"2016","journal-title":"J Bone Miner Res"},{"key":"2024012714000082200_jbmr4537-bib-0013","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat Med"},{"key":"2024012714000082200_jbmr4537-bib-0014","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1096\/fj.201700375R","article-title":"Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis","volume":"32","author":"Chandra","year":"2018","journal-title":"FASEB J"},{"key":"2024012714000082200_jbmr4537-bib-0015","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bone.2018.12.006","article-title":"Potential role of senescence in radiation-induced damage of the aged skeleton","volume":"120","author":"Chandra","year":"2019","journal-title":"Bone"},{"key":"2024012714000082200_jbmr4537-bib-0016","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2105-15-224","article-title":"MAP-RSeq: mayo analysis pipeline for RNA sequencing","volume":"15","author":"Kalari","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"2024012714000082200_jbmr4537-bib-0017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2024012714000082200_jbmr4537-bib-0018","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1093\/nar\/gkt214","article-title":"The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucl Acids Res"},{"key":"2024012714000082200_jbmr4537-bib-0019","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res"},{"key":"2024012714000082200_jbmr4537-bib-0020","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1093\/bioinformatics\/btu577","article-title":"RVboost: RNA-seq variants prioritization using a boosting method","volume":"30","author":"Wang","year":"2014","journal-title":"Bioinformatics"},{"key":"2024012714000082200_jbmr4537-bib-0021","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","article-title":"RSeQC: quality control of RNA-seq experiments","volume":"28","author":"Wang","year":"2012","journal-title":"Bioinformatics"},{"key":"2024012714000082200_jbmr4537-bib-0022","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2024012714000082200_jbmr4537-bib-0023","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucl Acids Res"},{"key":"2024012714000082200_jbmr4537-bib-0024","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1128\/MCB.01977-07","article-title":"MicroRNAs in the miR-106b family regulate p21\/CDKN1A and promote cell cycle progression","volume":"28","author":"Ivanovska","year":"2008","journal-title":"Mol Cell Biol"},{"key":"2024012714000082200_jbmr4537-bib-0025","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1474-9726.2010.00549.x","article-title":"miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging","volume":"9","author":"Hackl","year":"2010","journal-title":"Aging Cell"},{"key":"2024012714000082200_jbmr4537-bib-0026","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1111\/j.1742-4658.2009.06967.x","article-title":"A role of miR-27 in the regulation of adipogenesis","volume":"276","author":"Lin","year":"2009","journal-title":"FEBS J"},{"key":"2024012714000082200_jbmr4537-bib-0027","article-title":"Bone marrow adiposity is inversely associated with bone mineral density in postmenopausal females","volume":"17","author":"Milisic","year":"2020","journal-title":"Med Glas (Zenica)"},{"key":"2024012714000082200_jbmr4537-bib-0028","doi-asserted-by":"crossref","first-page":"19366","DOI":"10.18632\/oncotarget.4358","article-title":"Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic","volume":"6","author":"Nicolay","year":"2015","journal-title":"Oncotarget"},{"key":"2024012714000082200_jbmr4537-bib-0029","doi-asserted-by":"crossref","first-page":"e13247","DOI":"10.1111\/acel.13247","article-title":"Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice","volume":"19","author":"Almeida","year":"2020","journal-title":"Aging Cell"},{"key":"2024012714000082200_jbmr4537-bib-0030","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1093\/gerona\/glaa049","article-title":"Deletion of PPARgamma in mesenchymal lineage cells protects against aging-induced cortical bone loss in mice","volume":"75","author":"Cao","year":"2020","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2024012714000082200_jbmr4537-bib-0031","first-page":"583","article-title":"Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis","volume":"7","author":"Brennan","year":"2014","journal-title":"Dis Model Mech"},{"key":"2024012714000082200_jbmr4537-bib-0032","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.4161\/cc.8.13.8925","article-title":"The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses","volume":"8","author":"Turaga","year":"2009","journal-title":"Cell Cycle"},{"key":"2024012714000082200_jbmr4537-bib-0033","doi-asserted-by":"crossref","first-page":"21220","DOI":"10.1074\/jbc.M801824200","article-title":"Cyclin-dependent kinase inhibitor, p21WAF1\/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance","volume":"283","author":"Inoue","year":"2008","journal-title":"J Biol Chem"},{"key":"2024012714000082200_jbmr4537-bib-0034","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.7150\/thno.22565","article-title":"Adipocyte-derived exosomal MiR-27a induces insulin resistance in skeletal muscle through repression of PPARgamma","volume":"8","author":"Yu","year":"2018","journal-title":"Theranostics"},{"key":"2024012714000082200_jbmr4537-bib-0035","doi-asserted-by":"crossref","first-page":"106393","DOI":"10.1016\/j.domaniend.2019.106393","article-title":"miR-27a is an important adipogenesis regulator associated with differential lipid accumulation between intramuscular and subcutaneous adipose tissues of sheep","volume":"71","author":"Deng","year":"2020","journal-title":"Domest Anim Endocrinol"},{"key":"2024012714000082200_jbmr4537-bib-0036","doi-asserted-by":"crossref","first-page":"28056","DOI":"10.1038\/srep28056","article-title":"Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue","volume":"6","author":"Ahmad","year":"2016","journal-title":"Sci Rep"},{"key":"2024012714000082200_jbmr4537-bib-0037","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cmet.2007.08.010","article-title":"The rapidly expanding family of adipokines","volume":"6","author":"MacDougald","year":"2007","journal-title":"Cell Metab"},{"key":"2024012714000082200_jbmr4537-bib-0038","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1210\/en.2007-0175","article-title":"Chemerin is a novel adipokine associated with obesity and metabolic syndrome","volume":"148","author":"Bozaoglu","year":"2007","journal-title":"Endocrinology"},{"key":"2024012714000082200_jbmr4537-bib-0039","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1002\/stem.1450","article-title":"Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis","volume":"31","author":"Muruganandan","year":"2013","journal-title":"Stem Cells"},{"key":"2024012714000082200_jbmr4537-bib-0040","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1097\/GME.0000000000000655","article-title":"Association between circulatory levels of adipokines and bone mineral density in postmenopausal women","volume":"23","author":"Cervellati","year":"2016","journal-title":"Menopause"},{"key":"2024012714000082200_jbmr4537-bib-0041","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/MEG.0000000000000617","article-title":"Chemerin, visfatin, and vaspin serum levels in relation to bone mineral density in patients with inflammatory bowel disease","volume":"28","author":"Terzoudis","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2024012714000082200_jbmr4537-bib-0042","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.scr.2016.04.011","article-title":"Genome-wide analysis of gene expression during adipogenesis in human adipose-derived stromal cells reveals novel patterns of gene expression during adipocyte differentiation","volume":"16","author":"Ambele","year":"2016","journal-title":"Stem Cell Res"},{"key":"2024012714000082200_jbmr4537-bib-0043","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1242\/dev.067710","article-title":"Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis","volume":"138","author":"Birsoy","year":"2011","journal-title":"Development"},{"key":"2024012714000082200_jbmr4537-bib-0044","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1194\/jlr.M067207","article-title":"CXCL3 positively regulates adipogenic differentiation","volume":"57","author":"Kusuyama","year":"2016","journal-title":"J Lipid Res"},{"key":"2024012714000082200_jbmr4537-bib-0045","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.celrep.2016.12.015","article-title":"Amplification of adipogenic commitment by VSTM2A","volume":"18","author":"Secco","year":"2017","journal-title":"Cell Rep"},{"key":"2024012714000082200_jbmr4537-bib-0046","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2152\/jmi.53.238","article-title":"ALK7 is a novel marker for adipocyte differentiation","volume":"53","author":"Kogame","year":"2006","journal-title":"J Med Invest"},{"key":"2024012714000082200_jbmr4537-bib-0047","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1186\/1471-2164-12-461","article-title":"Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic development","volume":"12","author":"Menssen","year":"2011","journal-title":"BMC Genomics"},{"key":"2024012714000082200_jbmr4537-bib-0048","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s12038-014-9412-5","article-title":"DNA microarray analysis of genes differentially expressed in adipocyte differentiation","volume":"39","author":"Yin","year":"2014","journal-title":"J Biosci"},{"key":"2024012714000082200_jbmr4537-bib-0049","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/ijo.2009.263","article-title":"Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects","volume":"34","author":"Ortega","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"2024012714000082200_jbmr4537-bib-0050","doi-asserted-by":"crossref","first-page":"34089","DOI":"10.1074\/jbc.M105097200","article-title":"Galectin-12, an adipose-expressed galectin-like molecule possessing apoptosis-inducing activity","volume":"276","author":"Hotta","year":"2001","journal-title":"J Biol Chem"},{"key":"2024012714000082200_jbmr4537-bib-0051","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jcyt.2018.11.010","article-title":"Insulin-like growth factor 2 regulates the proliferation and differentiation of rat adipose-derived stromal cells via IGF-1R and IR","volume":"21","author":"Wang","year":"2019","journal-title":"Cytotherapy"},{"key":"2024012714000082200_jbmr4537-bib-0052","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/1471-2164-9-340","article-title":"Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis","volume":"9","author":"Scheideler","year":"2008","journal-title":"BMC Genomics"},{"key":"2024012714000082200_jbmr4537-bib-0053","doi-asserted-by":"crossref","first-page":"28175","DOI":"10.1074\/jbc.M700793200","article-title":"Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism","volume":"282","author":"Goralski","year":"2007","journal-title":"J Biol Chem"},{"key":"2024012714000082200_jbmr4537-bib-0054","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbrc.2009.12.142","article-title":"Identification of a new secretory factor, CCDC3\/Favine, in adipocytes and endothelial cells","volume":"392","author":"Kobayashi","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"2024012714000082200_jbmr4537-bib-0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.plefa.2015.04.008","article-title":"SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition","volume":"98","author":"Ralston","year":"2015","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"2024012714000082200_jbmr4537-bib-0056","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12864-017-3728-0","article-title":"Gene expression profile during proliferation and differentiation of rainbow trout adipocyte precursor cells","volume":"18","author":"Bou","year":"2017","journal-title":"BMC Genomics"},{"key":"2024012714000082200_jbmr4537-bib-0057","first-page":"924","article-title":"Dynamic changes in lipid droplet-associated proteins in the \u201cbrowning\u201d of white adipose tissues","volume":"2013","author":"Barneda","year":"1831","journal-title":"Biochim Biophys Acta"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/5\/997\/55457553\/jbmr4537.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/5\/997\/55457553\/jbmr4537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:42Z","timestamp":1710328122000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/5\/997-1011\/7516671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3,5]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4537","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4537\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4537\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}