{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:50:34Z","timestamp":1792270234920,"version":"4.4.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":482,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970953"],"award-info":[{"award-number":["81970953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001072"],"award-info":[{"award-number":["82001072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2019SF-102"],"award-info":[{"award-number":["2019SF-102"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2020JQ-453"],"award-info":[{"award-number":["2020JQ-453"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2021SF-046"],"award-info":[{"award-number":["2021SF-046"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2021JM-229"],"award-info":[{"award-number":["2021JM-229"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970953"],"award-info":[{"award-number":["81970953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001072"],"award-info":[{"award-number":["82001072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2019SF\u2010102"],"award-info":[{"award-number":["2019SF\u2010102"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2020JQ\u2010453"],"award-info":[{"award-number":["2020JQ\u2010453"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2021SF\u2010046"],"award-info":[{"award-number":["2021SF\u2010046"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Natural Science Foundation of Shaanxi Province","doi-asserted-by":"publisher","award":["2021JM\u2010229"],"award-info":[{"award-number":["2021JM\u2010229"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage-associated molecular patterns (DAMPs). However, the role of necroptosis and downstream key DAMPs in TMJOA is unknown. Here, rodent models of TMJOA were established by the unilateral anterior crossbite (UAC). Transmission electron microscopy (TEM) and immunohistochemistry of receptor interacting protein kinase 3 (RIPK3)\/phosphorylation of mixed lineage kinase domain-like protein (pMLKL) were conducted to evaluate the occurrence of necroptosis in vivo. The therapeutic effects of blocking necroptosis were achieved by intra-articularly injecting RIPK3 or MLKL inhibitors and using RIPK3 or MLKL knockout mice. In vitro necroptosis of condylar chondrocyte was induced by combination of tumor necrosis factor alpha (TNF\u03b1), second mitochondria-derived activator of caspases (SMAC) mimetics and carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone (z-VAD-fmk). The possible DAMPs released by necroptotic chondrocytes were screened by quantitative proteomics and blocked by specific antibody. Translucent cytosol, swollen organelles, and ruptured cell membranes, features of necroptosis, were frequently manifested in chondrocytes at the early stage of condylar cartilage degeneration in TMJOA, which was accompanied by upregulation of RIPK3\/pMLKL. Inhibiting or knocking out RIPK3\/MLKL significantly prevented cartilage degeneration. DAMPs released by necroptotic condylar chondrocytes, such as syndecan 4 (SDC4) and heat shock protein 90 (HSP90), were verified. Furthermore, blocking the function of SDC4 significantly attenuated the expression of TNF\u03b1 in cartilage and synovium, and accordingly increased cartilage thickness and reduced synovial inflammation. Thus, the necroptotic vicious cycle of TNF\u03b1-SDC4-TNF\u03b1 contributes to cartilage degeneration and synovitis, and can serve as a potential therapeutic target for treating TMJOA. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4542","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T09:13:19Z","timestamp":1647076399000},"page":"1044-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Necroptotic TNF\u03b1-Syndecan 4-TNF\u03b1 Vicious Cycle as a Therapeutic Target for Preventing Temporomandibular Joint Osteoarthritis"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0767-6006","authenticated-orcid":false,"given":"Feng","family":"He","sequence":"first","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjun","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Stomatology Seventh Medical Center of Chinese PLA General Hospital Beijing PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhe","family":"Ren","sequence":"additional","affiliation":[{"name":"Health Science Center Xi'an Jiaotong University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, Department of Central Sterile Supply, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuge","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianle","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxu","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2464-361X","authenticated-orcid":false,"given":"Mian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Diseases, Department of Medical Rehabilitation, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Institute of Neurosciences, School of Basic Medicine, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibin","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Oral Diseases, School of Stomatology, the Fourth Military Medical University Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,12]]},"reference":[{"key":"2024012714002899900_jbmr4542-bib-0001","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1056\/NEJMra0802472","article-title":"Temporomandibular disorders","volume":"359","author":"Scrivani","year":"2008","journal-title":"N Engl J Med"},{"key":"2024012714002899900_jbmr4542-bib-0002","doi-asserted-by":"crossref","first-page":"h1154","DOI":"10.1136\/bmj.h1154","article-title":"Temporomandibular disorders","volume":"350","author":"Durham","year":"2015","journal-title":"BMJ"},{"key":"2024012714002899900_jbmr4542-bib-0003","first-page":"Cd007261","article-title":"Interventions for the management of temporomandibular joint osteoarthritis","volume":"2012","author":"de Souza","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2024012714002899900_jbmr4542-bib-0004","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/S0140-6736(18)31064-X","article-title":"Osteoarthritis","volume":"391","author":"Barnett","year":"2018","journal-title":"Lancet"},{"key":"2024012714002899900_jbmr4542-bib-0005","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.3390\/ijms17122146","article-title":"Insights on molecular mechanisms of chondrocytes death in osteoarthritis","volume":"17","author":"Charlier","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2024012714002899900_jbmr4542-bib-0006","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte apoptosis in the pathogenesis of osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2024012714002899900_jbmr4542-bib-0007","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2019.1606647","article-title":"MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"key":"2024012714002899900_jbmr4542-bib-0008","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"2024012714002899900_jbmr4542-bib-0009","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"2024012714002899900_jbmr4542-bib-0010","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"key":"2024012714002899900_jbmr4542-bib-0011","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature"},{"key":"2024012714002899900_jbmr4542-bib-0012","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-med-041316-085215","article-title":"Targeting RAGE signaling in inflammatory disease","volume":"69","author":"Hudson","year":"2018","journal-title":"Annu Rev Med"},{"key":"2024012714002899900_jbmr4542-bib-0013","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1074-7613(01)00111-X","article-title":"CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin","volume":"14","author":"Basu","year":"2001","journal-title":"Immunity"},{"key":"2024012714002899900_jbmr4542-bib-0014","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1182\/blood-2011-07-368720","article-title":"Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation","volume":"120","author":"Brennan","year":"2012","journal-title":"Blood"},{"key":"2024012714002899900_jbmr4542-bib-0015","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-pathmechdis-012419-032847","article-title":"DAMPs, PAMPs, and LAMPs in immunity and sterile inflammation","volume":"15","author":"Zindel","year":"2020","journal-title":"Annu Rev Pathol"},{"key":"2024012714002899900_jbmr4542-bib-0016","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2024012714002899900_jbmr4542-bib-0017","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41577-019-0215-7","article-title":"DAMP-sensing receptors in sterile inflammation and inflammatory diseases","volume":"20","author":"Gong","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"2024012714002899900_jbmr4542-bib-0018","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bone.2018.03.008","article-title":"Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone","volume":"111","author":"Ye","year":"2018","journal-title":"Bone"},{"key":"2024012714002899900_jbmr4542-bib-0019","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.joca.2017.05.007","article-title":"Matrix replenishing by BMSCs is beneficial for osteoarthritic temporomandibular joint cartilage","volume":"25","author":"Zhang","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"2024012714002899900_jbmr4542-bib-0020","doi-asserted-by":"crossref","first-page":"115123","DOI":"10.1016\/j.bone.2019.115123","article-title":"The effect of oestrogen on mandibular condylar cartilage via hypoxia-inducible factor-2alpha during osteoarthritis development","volume":"130","author":"Ye","year":"2019","journal-title":"Bone"},{"key":"2024012714002899900_jbmr4542-bib-0021","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"2024012714002899900_jbmr4542-bib-0022","doi-asserted-by":"crossref","first-page":"39738","DOI":"10.1074\/jbc.M111.264549","article-title":"TNF-\u03b1 and IL-1\u03b2 promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc","volume":"286","author":"Wang","year":"2011","journal-title":"J Biol Chem"},{"key":"2024012714002899900_jbmr4542-bib-0023","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1016\/j.ajpath.2014.06.006","article-title":"Tumor necrosis factor-\u03b1- and interleukin-1\u03b2-dependent matrix metalloproteinase-3 expression in nucleus pulposus cells requires cooperative signaling via syndecan 4 and mitogen-activated protein kinase-NF-\u03baB axis: implications in inflammatory disc disease","volume":"184","author":"Wang","year":"2014","journal-title":"Am J Pathol"},{"key":"2024012714002899900_jbmr4542-bib-0024","doi-asserted-by":"crossref","first-page":"8746858","DOI":"10.1155\/2018\/8746858","article-title":"Temporomandibular disorders: \"occlusion\" matters!","volume":"2018","author":"de Kanter","year":"2018","journal-title":"Pain Res Manag"},{"key":"2024012714002899900_jbmr4542-bib-0025","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.joca.2015.12.009","article-title":"Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats","volume":"24","author":"Zhang","year":"2016","journal-title":"Osteoarthr Cartil"},{"key":"2024012714002899900_jbmr4542-bib-0026","doi-asserted-by":"crossref","first-page":"e0141774","DOI":"10.1371\/journal.pone.0141774","article-title":"TNF accelerates death of mandibular condyle chondrocytes in rats with biomechanical stimulation-induced temporomandibular joint disease","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS One"},{"key":"2024012714002899900_jbmr4542-bib-0027","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.intimp.2018.11.007","article-title":"Protective effects of alogliptin against TNF-\u03b1-induced degradation of extracellular matrix in human chondrocytes","volume":"68","author":"Zhang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"2024012714002899900_jbmr4542-bib-0028","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41419-020-2328-0","article-title":"Inhibition of keratinocyte necroptosis mediated by RIPK1\/RIPK3\/MLKL provides a protective effect against psoriatic inflammation","volume":"11","author":"Duan","year":"2020","journal-title":"Cell Death Dis"},{"key":"2024012714002899900_jbmr4542-bib-0029","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.3390\/ijms21124204","article-title":"Cartilage trauma induces Necroptotic chondrocyte death and expulsion of cellular contents","volume":"21","author":"Stolberg-Stolberg","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2024012714002899900_jbmr4542-bib-0030","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/annrheumdis-2020-217904","article-title":"TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis","volume":"79","author":"Jeon","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2024012714002899900_jbmr4542-bib-0031","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.14336\/AD.2019.1127","article-title":"Pyroptosis plays a role in osteoarthritis","volume":"11","author":"An","year":"2020","journal-title":"Aging Dis"},{"key":"2024012714002899900_jbmr4542-bib-0032","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"2024012714002899900_jbmr4542-bib-0033","doi-asserted-by":"crossref","first-page":"695041","DOI":"10.3389\/fcell.2021.695041","article-title":"IRE1-mTOR-PERK Axis coordinates autophagy and ER stress-apoptosis induced by P2X7-mediated Ca(2+) influx in osteoarthritis","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2024012714002899900_jbmr4542-bib-0034","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41419-019-1930-5","article-title":"Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis","volume":"10","author":"Riegger","year":"2019","journal-title":"Cell Death Dis"},{"key":"2024012714002899900_jbmr4542-bib-0035","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.joca.2017.03.018","article-title":"Mechanical force-mediated pathological cartilage thinning is regulated by necroptosis and apoptosis","volume":"25","author":"Zhang","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"2024012714002899900_jbmr4542-bib-0036","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.joca.2020.01.003","article-title":"Early stage blockade of the alarmin HMGB1 reduces cartilage destruction in experimental OA","volume":"28","author":"Aulin","year":"2020","journal-title":"Osteoarthr Cartil"},{"key":"2024012714002899900_jbmr4542-bib-0037","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/s13075-017-1426-6","article-title":"S100A8\/A9 increases the mobilization of pro-inflammatory Ly6C(high) monocytes to the synovium during experimental osteoarthritis","volume":"19","author":"Cremers","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"2024012714002899900_jbmr4542-bib-0038","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1002\/art.38000","article-title":"Hsp90 inhibition protects against biomechanically induced osteoarthritis in rats","volume":"65","author":"Siebelt","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2024012714002899900_jbmr4542-bib-0039","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1440-169X.2010.01230.x","article-title":"Role of syndecan-4 side chains in turkey satellite cell growth and development","volume":"53","author":"Song","year":"2011","journal-title":"Dev Growth Differ"},{"key":"2024012714002899900_jbmr4542-bib-0040","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.200210176","article-title":"Integrin-specific signaling pathways controlling focal adhesion formation and cell migration","volume":"161","author":"Mostafavi-Pour","year":"2003","journal-title":"J Cell Biol"},{"key":"2024012714002899900_jbmr4542-bib-0041","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.1998","article-title":"Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis","volume":"15","author":"Echtermeyer","year":"2009","journal-title":"Nat Med"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4542","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4542","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/5\/1044\/55459460\/jbmr4542.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/5\/1044\/55459460\/jbmr4542.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:44Z","timestamp":1710328124000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/5\/1044-1055\/7516816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3,12]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4542","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4542\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4542\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4542\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4542\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4542\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4542\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4542\/v1\/review2","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-10-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}