{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:06:18Z","timestamp":1791396378295,"version":"4.3.3"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":522,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pharmacosmos"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Randomized control trials (RCTs) have shown that certain intravenous iron preparations can induce high levels of fibroblast growth factor 23 (FGF-23) and persistent hypophosphatemia. Repeated iron infusions may lead to prolonged hypophosphatemia and osteomalacia events not captured by RCTs. Several previous case reports have described skeletal adverse effects after repeated iron infusions. To characterize these effects, we conducted a systematic review of case reports. MEDLINE, Embase, Web of Science, and Cochrane databases were searched in March 2021. We selected case reports of patients \u226516\u2009years old. Study quality was assessed using the tool from Murad and colleagues. We report the results in a narrative summary. We identified 28 case reports, reporting 30 cases. Ages ranged from 28 to 80\u2009years (median 50\u2009years). Most patients (n\u00a0=\u00a018) received ferric carboxymaltose (FCM), whereas 8 received saccharated ferric oxide (SFO) and 3 received iron polymaltose (IPM). All but 2 cases had more than five infusions (range 2 to 198, median 17). The lowest phosphate levels ranged from 0.16 to 0.77\u2009mmol\/L (median 0.36\u2009mmol\/L). Intact FGF-23 (iFGF-23) was high when measured. Serum 25OH vitamin D was low in 10 of 21 cases measured and 1,25(OH)2 vitamin D in 12 of 18. Alkaline phosphatase was high in 18 of 22 cases. Bone or muscle pain was reported in 28 of the 30 cases. Twenty patients had pseudofractures, 9 had fractures, and 6 patients had both. All 15 available bone scans showed focal isotope uptake. Case reports tend to report severe cases, so potential reporting bias should be considered. Osteomalacia is a potential complication of repeated iron infusion, especially in patients with gastrointestinal disorders receiving prolonged therapy. Pain and fractures or pseudofractures are common clinical findings, associated with low phosphate, high iFGF-23, high alkaline phosphatase, and abnormal isotope bone scan. Discontinuing or switching the iron formulation was an effective intervention in most cases. \u00a9 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4558","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:18:27Z","timestamp":1649981907000},"page":"1188-1199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Osteomalacia as a Complication of Intravenous Iron Infusion: A Systematic Review of Case Reports"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9227-6076","authenticated-orcid":false,"given":"Tatiane","family":"Vilaca","sequence":"first","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Velmurugan","sequence":"additional","affiliation":[{"name":"Department of Medicine Holb\u00e6k Hospital Holb\u00e6k Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Smith","sequence":"additional","affiliation":[{"name":"Open Patient Data Explorative Network, Department of Clinical Research University of Southern Denmark Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-6080","authenticated-orcid":false,"given":"Bo","family":"Abrahamsen","sequence":"additional","affiliation":[{"name":"Denmark and NDORMS University of Oxford Oxford UK"},{"name":"Open Patient Data Explorative Network, Department of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"Department of Medicine Holb\u00e6k Hospital Holb\u00e6k Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-3366","authenticated-orcid":false,"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"issue":"4","key":"2024012713573120500_jbmr4558-bib-0001","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MNH.0000000000000329","article-title":"Iron-induced hypophosphatemia: an emerging complication","volume":"26","author":"Zoller","year":"2017","journal-title":"Curr Opin Nephrol Hypertens."},{"issue":"2","key":"2024012713573120500_jbmr4558-bib-0002","doi-asserted-by":"crossref","first-page":"R57\u201365","DOI":"10.1530\/JME-20-0089","article-title":"FGF23-related hypophosphatemic rickets\/osteomalacia: diagnosis and new treatment","volume":"66","author":"Fukumoto","year":"2021","journal-title":"J Mol Endocrinol."},{"issue":"5","key":"2024012713573120500_jbmr4558-bib-0003","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/jama.2019.22450","article-title":"Effects of iron isomaltoside vs ferric carboxymaltose on hypophosphatemia in iron-deficiency anemia: two randomized clinical trials","volume":"323","author":"Wolf","year":"2020","journal-title":"JAMA."},{"issue":"8","key":"2024012713573120500_jbmr4558-bib-0004","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1002\/jbmr.1923","article-title":"Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women","volume":"28","author":"Wolf","year":"2013","journal-title":"J Bone Miner Res."},{"issue":"23","key":"2024012713573120500_jbmr4558-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.124486","article-title":"Randomized trial of intravenous iron-induced hypophosphatemia","volume":"3","author":"Wolf","year":"2018","journal-title":"JCI Insight."},{"key":"2024012713573120500_jbmr4558-bib-0006","volume-title":"The Cochrane Collaboration","author":"Higgins","year":"2011"},{"issue":"7","key":"2024012713573120500_jbmr4558-bib-0007","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"issue":"5","key":"2024012713573120500_jbmr4558-bib-0008","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/bcp.14643","article-title":"Hypophosphatemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside\u2014a systematic review and meta-analysis","volume":"87","author":"Schaefer","year":"2021","journal-title":"Br J Clin Pharmacol."},{"issue":"7","key":"2024012713573120500_jbmr4558-bib-0009","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41581-019-0152-5","article-title":"Clinical practice recommendations for the diagnosis and management of X-linked hypophosphatemia","volume":"15","author":"Haffner","year":"2019","journal-title":"Nat Rev Nephrol."},{"issue":"2","key":"2024012713573120500_jbmr4558-bib-0010","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad","year":"2018","journal-title":"BMJ Evid Based Med."},{"issue":"8","key":"2024012713573120500_jbmr4558-bib-0011","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1093\/rheumatology\/kez627","article-title":"Novel use of burosumab in refractory iron-induced FGF23-mediated hypophosphataemic osteomalacia","volume":"59","author":"Amarnani","year":"2020","journal-title":"Rheumatology (Oxford)."},{"issue":"559","key":"2024012713573120500_jbmr4558-bib-0012","first-page":"838","article-title":"Phosphocalcic anomalies and bone fragility keys for the general practitioner","volume":"13","author":"Aubry-Rozier","year":"2017","journal-title":"Rev Med Suisse."},{"issue":"3","key":"2024012713573120500_jbmr4558-bib-0013","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/jbmr.3319","article-title":"Hypophosphatemia, severe bone pain, gait disturbance, and fatigue fractures after iron substitution in inflammatory bowel disease: a case report","volume":"33","author":"Bartko","year":"2018","journal-title":"J Bone Miner Res."},{"issue":"1\u20132","key":"2024012713573120500_jbmr4558-bib-0014","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/2042018816678363","article-title":"Long-term iron polymaltose infusions associated with hypophosphataemic osteomalacia: a report of two cases and review of the literature","volume":"8","author":"Bishay","year":"2017","journal-title":"Ther Adv Endocrinol Metab."},{"key":"2024012713573120500_jbmr4558-bib-0015","first-page":"1","article-title":"Severe osteomalacia with multiple insufficiency fractures secondary to intravenous iron therapy in a patient with Rendu-Osler-weber syndrome","volume":"13","author":"Callejas-Moraga","year":"2020","journal-title":"Bone Rep."},{"issue":"5","key":"2024012713573120500_jbmr4558-bib-0016","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/jgh3.12150","article-title":"Symptomatic severe hypophosphatemia after intravenous ferric carboxymaltose","volume":"3","author":"Fang","year":"2019","journal-title":"JGH Open."},{"issue":"2","key":"2024012713573120500_jbmr4558-bib-0017","doi-asserted-by":"crossref","first-page":"102","DOI":"10.52964\/AMJA.0809","article-title":"Ferric carboxymaltose (Ferinject) associated hypophosphatemia: case report illustrating the need for increased awareness to minimise incidence and risk","volume":"19","author":"Fisher","year":"2020","journal-title":"Acute Med."},{"key":"2024012713573120500_jbmr4558-bib-0018","first-page":"1675654","article-title":"A case of an insufficiency fracture of the medial proximal tibia secondary to osteomalacia associated with long-term saccharated ferric oxide administration","volume":"2017","author":"Ishimaru","year":"2017","journal-title":"Case Rep Orthop."},{"key":"2024012713573120500_jbmr4558-bib-0019","first-page":"1","article-title":"Severe FGF23-based hypophosphataemic osteomalacia due to ferric carboxymaltose administration","volume":"2018","author":"Klein","year":"2018","journal-title":"BMJ Case Rep."},{"key":"2024012713573120500_jbmr4558-bib-0020","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s11560-017-0218-y","article-title":"Hypophosphat\u00e4mie und FGF-23-Erh\u00f6hung bei normaler Nierenfunktion. Hypophosphataemia and FGF-23-Increase with Normal Renal Function An unusual constellation","volume":"13","author":"Lehmann","year":"2018","journal-title":"The Nephrologist"},{"issue":"2","key":"2024012713573120500_jbmr4558-bib-0021","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4045\/tidsskr.12.0494","article-title":"Uncommon adverse effect of a common medication","volume":"133","author":"Moore","year":"2013","journal-title":"Tidsskr Nor Laegeforen."},{"issue":"39","key":"2024012713573120500_jbmr4558-bib-0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000008147","article-title":"A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome a case report","volume":"96","author":"Nomoto","year":"2017","journal-title":"Medicine."},{"issue":"105","key":"2024012713573120500_jbmr4558-bib-0023","first-page":"61","article-title":"Hypophosphat\u00e9mie et FGF23 \u00e9lev\u00e9 Hypophosphataemia and elevated FGF23","volume":"12","author":"Poursac","year":"2015","journal-title":"Rhumatos"},{"issue":"02","key":"2024012713573120500_jbmr4558-bib-0024","doi-asserted-by":"crossref","first-page":"931","DOI":"10.4172\/2165-7920.1000931","article-title":"Hypophosphataemic rickets due to parenteral ferrous carboxymaltose in a young man with Crohn disease and iron deficiency: a case report and review of literature","volume":"7","author":"Reyes","year":"2017","journal-title":"J Clin Case Rep."},{"issue":"5","key":"2024012713573120500_jbmr4558-bib-0025","first-page":"340","article-title":"Intravenous iron induced severe hypophophatemia in a gastric bypass patient","volume":"66","author":"Gomez Rodriguez","year":"2019","journal-title":"Endocrinol Diabetes Nutr (Engl Ed)."},{"issue":"6","key":"2024012713573120500_jbmr4558-bib-0026","first-page":"391","article-title":"Symptomatic hypophosphataemic osteomalacia secondary to the treatment with iron carboxymaltose detected in bone scintigraphy","volume":"35","author":"Sangros Sahun","year":"2016","journal-title":"Rev Esp Med Nucl Imagen Mol."},{"issue":"1","key":"2024012713573120500_jbmr4558-bib-0027","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S8756-3282(97)00084-7","article-title":"Saccharated ferric oxide (SFO)-induced osteomalacia: in vitro inhibition by SFO of bone formation and 1,25-dihydroxy-vitamin D production in renal tubules","volume":"21","author":"Sato","year":"1997","journal-title":"Bone."},{"issue":"6","key":"2024012713573120500_jbmr4558-bib-0028","doi-asserted-by":"crossref","first-page":"e5\u20136","DOI":"10.1053\/j.gastro.2016.09.050","article-title":"Blood and bone loser","volume":"152","author":"Schaefer","year":"2017","journal-title":"Gastroenterology."},{"issue":"2","key":"2024012713573120500_jbmr4558-bib-0029","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1258\/acb.2008.008151","article-title":"Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia","volume":"46","author":"Schouten","year":"2009","journal-title":"Ann Clin Biochem."},{"issue":"9","key":"2024012713573120500_jbmr4558-bib-0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.medcli.2013.06.024","article-title":"Arthralgias and fractures in an adult male: beyond hypovitaminosis D","volume":"142","author":"Tejera Segura","year":"2014","journal-title":"Med Clin (Barc)."},{"issue":"4","key":"2024012713573120500_jbmr4558-bib-0031","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.bone.2009.06.017","article-title":"Hypophosphatemia induced by intravenous administration of saccharated ferric oxide another form of FGF23-related hypophosphatemia","volume":"45","author":"Shimizu","year":"2009","journal-title":"Bone."},{"issue":"3","key":"2024012713573120500_jbmr4558-bib-0032","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/jbmr.3372","article-title":"Re: hypophosphatemia, severe bone pain, gait disturbance, and fatigue fractures after iron substitution in inflammatory bowel disease: a case report","volume":"33","author":"Tournis","year":"2018","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024012713573120500_jbmr4558-bib-0033","first-page":"4","article-title":"Osteomalacia and insufficiency fractures secondary to intravenous iron therapy: a case report","volume":"10","author":"Tozzi","year":"2020","journal-title":"J Orthop Case Rep."},{"issue":"3","key":"2024012713573120500_jbmr4558-bib-0034","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jbmr.3369","article-title":"Iron supplementation-induced phosphaturic osteomalacia: FGF23 is the culprit","volume":"33","author":"Urbina","year":"2018","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024012713573120500_jbmr4558-bib-0035","first-page":"464","article-title":"Life-threatening hypophosphatemia following intravenous iron infusion","volume":"41","author":"Vasquez-Rios","year":"2021","journal-title":"Nefrologia"},{"issue":"17","key":"2024012713573120500_jbmr4558-bib-0036","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.2169\/internalmedicine.51.7450","article-title":"Fibroblast growth factor 23-related osteomalacia caused by the prolonged administration of saccharated ferric oxide","volume":"51","author":"Yamamoto","year":"2012","journal-title":"Intern Med."},{"issue":"1","key":"2024012713573120500_jbmr4558-bib-0037","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7888\/juoeh.35.25","article-title":"Iatrogenic osteomalacia: report of two cases","volume":"35","author":"Yamamoto","year":"2013","journal-title":"J UOEH."},{"issue":"1","key":"2024012713573120500_jbmr4558-bib-0038","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ajh.2830430121","article-title":"Iatrogenic osteomalacia caused by intravenous administration of saccharated ferric oxide","volume":"43","author":"Suzuki","year":"1993","journal-title":"Am J Hematol."},{"issue":"1","key":"2024012713573120500_jbmr4558-bib-0039","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12876-020-01298-9","article-title":"Hypophosphatemia after ferric carboxymaltose is unrelated to symptoms, intestinal inflammation or vitamin D status","volume":"20","author":"Fang","year":"2020","journal-title":"BMC Gastroenterol."},{"issue":"7","key":"2024012713573120500_jbmr4558-bib-0040","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1210\/jc.2008-2396","article-title":"FGF23 elevation and hypophosphatemia after intravenous iron polymaltose: a prospective study","volume":"94","author":"Schouten","year":"2009","journal-title":"J Clin Endocrinol Metabol."},{"key":"2024012713573120500_jbmr4558-bib-0041","doi-asserted-by":"crossref","first-page":"116202","DOI":"10.1016\/j.bone.2021.116202","article-title":"Hypophosphatemia after intravenous iron therapy: comprehensive review of clinical findings and recommendations for management","volume":"154","author":"Schaefer","year":"2021","journal-title":"Bone."},{"key":"2024012713573120500_jbmr4558-bib-0042","first-page":"1105","article-title":"Does intravenous iron therapy decrease serum phosphorus levels?","volume":"28","author":"Wolf","year":"2017","journal-title":"J Am Soc Nephrol."},{"issue":"1","key":"2024012713573120500_jbmr4558-bib-0043","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41581-019-0189-5","article-title":"FGF23 at the crossroads of phosphate, iron economy and erythropoiesis","volume":"16","author":"Edmonston","year":"2020","journal-title":"Nat Rev Nephrol."},{"issue":"11","key":"2024012713573120500_jbmr4558-bib-0044","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1210\/jc.2011-1239","article-title":"Iron modifies plasma FGF23 differently in autosomal dominant hypophosphatemic rickets and healthy humans","volume":"96","author":"Imel","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"key":"2024012713573120500_jbmr4558-bib-0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7573\/dic.2020-11-3","article-title":"Hypophosphatemia, fibroblast growth factor 23 and third-generation intravenous iron compounds: a narrative review","volume":"10","author":"Kassianides","year":"2021","journal-title":"Drugs Context."},{"issue":"11","key":"2024012713573120500_jbmr4558-bib-0046","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.3390\/jcm9113587","article-title":"A pooled analysis of serum phosphate measurements and potential hypophosphatemia events in 45 interventional trials with ferric carboxymaltose","volume":"9","author":"Rosano","year":"2020","journal-title":"J Clin Med."},{"issue":"5","key":"2024012713573120500_jbmr4558-bib-0047","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/bcp.14643","article-title":"Hypophosphatemia after treatment of iron deficiency with intravenous ferric carboxymaltose or iron isomaltoside\u2014a systematic review and meta-analysis","volume":"87","author":"Schaefer","year":"2021","journal-title":"Br J Clin Pharmacol."},{"key":"2024012713573120500_jbmr4558-bib-0048","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2147\/TCRM.S243462","article-title":"Hypophosphatemia associated with intravenous iron therapies for iron deficiency anemia: a systematic literature review","volume":"16","author":"Glaspy","year":"2020","journal-title":"Ther Clin Risk Manag."},{"key":"2024012713573120500_jbmr4558-bib-0049","author":"MHRA","year":"2020"},{"issue":"2","key":"2024012713573120500_jbmr4558-bib-0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jocd.2011.03.004","article-title":"The 2011 IOM report on vitamin D and calcium requirements for North America: clinical implications for providers treating patients with low bone mineral density","volume":"14","author":"Rosen","year":"2011","journal-title":"J Clin Densitom."},{"key":"2024012713573120500_jbmr4558-bib-0051","volume-title":"Metabolic disorders of bone","year":"1974"},{"issue":"5","key":"2024012713573120500_jbmr4558-bib-0052","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1111\/bcp.13189","article-title":"Drug-specific hypophosphatemia and hypersensitivity reactions following different intravenous iron infusions","volume":"83","author":"Bager","year":"2017","journal-title":"Br J Clin Pharmacol."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/6\/1188\/55457209\/jbmr4558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/6\/1188\/55457209\/jbmr4558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:08:50Z","timestamp":1710328130000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/6\/1188-1199\/7516654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,4,14]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4558","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4558\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4558\/v3\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2021-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}