{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:27Z","timestamp":1786977987270,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":570,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003765","name":"Campus Bio-Medico University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003765","name":"Universit\u00e0 Campus Bio-Medico di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In hypoparathyroidism (HypoPT), calcium supplementation is virtually always required, although the disease is likely to be associated with an increased risk of nephrolithiasis. The use of calcium citrate (Ca-Cit) theoretically could have a positive impact on the nephrolithiasis risk because citrate salts are used to reduce this risk. Our objective was to evaluate the potential therapeutic advantage of Ca-Cit in comparison with calcium carbonate (CaCO3) in HypoPT, on nephrolithiasis risk factors, as well as to their ability to maintain desirable serum calcium levels. We also evaluated these preparations on quality of life (QOL). This randomized, double-blind, crossover trial recruited 24 adults with postsurgical chronic hypoparathyroidism at Campus Bio-Medico University of Rome. Participants were randomized 1:1 to Ca-Cit or CaCO3 for 1 month and then crossed over to the other treatment for another month. The primary outcomes were changes in albumin-adjusted serum calcium and in ion activity product of calcium oxalate levels (AP[CaOx] index). Secondary efficacy outcomes included changes in SF-36 survey score, fatigue score, constipation, and adverse events. No difference in terms of AP(CaOx) index was observed between the two groups. However, Ca-Cit was associated with a significant reduction in the oxalate\/creatinine ratio compared with CaCO3 (\u22122.46\u2009mmol\/mol [SD 11.93] versus 7.42\u2009mmol\/mol [SD 17.63], p\u00a0=\u00a00.029). Serum calcium and phosphorus concentration was not different between the two calcium preparations. Ca-Cit was associated with less constipation (p\u00a0=\u00a00.047). No difference was found in QOL scores. Although Ca-Cit did not modify the AP(CaOx) index when compared with CaCO3, it was associated with a reduction in urinary oxalate excretion that could have a potential beneficial effect on nephrolithiasis risk. These results are likely to have clinical implications in HypoPT, particularly those who do not tolerate CaCO3 and those affected by nephrolithiasis. A longer-term experience is needed to confirm these findings. \u00a9 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4564","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T02:53:17Z","timestamp":1650855197000},"page":"1251-1259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Crossover Clinical Trial"],"prefix":"10.1093","volume":"37","author":[{"given":"Anda Mihaela","family":"Naciu","sequence":"first","affiliation":[{"name":"Unit of Endocrinology and Diabetes Campus Bio-Medico University Rome"},{"name":"Unit of Metabolic Bone and Thyroid Disorders Fondazione Policlinico Universitario Campus Bio-Medico Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Tabacco","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Campus Bio-Medico University Rome"},{"name":"Unit of Metabolic Bone and Thyroid Disorders Fondazione Policlinico Universitario Campus Bio-Medico Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Vagelos College of Physicians & Surgeons Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Santonati","sequence":"additional","affiliation":[{"name":"Department of Endocrinology San Giovanni Addolorata Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Endocrinology San Giovanni Addolorata Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1818-0105","authenticated-orcid":false,"given":"Giosu\u00e8 Giordano","family":"Incognito","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Campus Bio-Medico University Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Gaspa","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition University Campus Bio-Medico Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Campus Bio-Medico University Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Falchetti","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Trimboli","sequence":"additional","affiliation":[{"name":"Clinic for Endocrinology and Diabetology Lugano Regional Hospital, Ente Ospedaliero Cantonale Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gherardo","family":"Mazziotti","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-8205","authenticated-orcid":false,"given":"Nicola","family":"Napoli","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Campus Bio-Medico University Rome"},{"name":"Unit of Metabolic Bone and Thyroid Disorders Fondazione Policlinico Universitario Campus Bio-Medico Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sanson","sequence":"additional","affiliation":[{"name":"Clinical Department of Medical, Surgical, and Health Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cesareo","sequence":"additional","affiliation":[{"name":"UOS Malattie Metaboliche Santa Maria Goretti Hospital Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Vescini","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Unit University-Hospital S. 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Misericordia of Udine Udine Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-4926","authenticated-orcid":false,"given":"Andrea","family":"Palermo","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes Campus Bio-Medico University Rome"},{"name":"Unit of Metabolic Bone and Thyroid Disorders Fondazione Policlinico Universitario Campus Bio-Medico Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,24]]},"reference":[{"issue":"3","key":"2024012713590113900_jbmr4564-bib-0001","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1530\/EJE-19-0316","article-title":"Unmet therapeutic, educational and scientific needs in parathyroid disorders: consensus statement from the first European Society of Endocrinology Workshop (PARAT)","volume":"181","author":"Bollerslev","year":"2019","journal-title":"Eur J Endocrinol."},{"issue":"2","key":"2024012713590113900_jbmr4564-bib-0002","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-15-0628","article-title":"European Society of Endocrinology clinical guideline: treatment of chronic hypoparathyroidism in adults","volume":"173","author":"Bollerslev","year":"2015","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"2024012713590113900_jbmr4564-bib-0003","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1210\/jc.2015-3907","article-title":"Management of hypoparathyroidism: summary statement and guidelines","volume":"101","author":"Brandi","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2024012713590113900_jbmr4564-bib-0004","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/jcb.10330","article-title":"Mechanisms of intestinal calcium absorption","volume":"88","author":"Bronner","year":"2003","journal-title":"J Cell Biochem."},{"issue":"3","key":"2024012713590113900_jbmr4564-bib-0005","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11154-019-09520-0","article-title":"Calcium citrate: from biochemistry and physiology to clinical applications","volume":"20","author":"Palermo","year":"2019","journal-title":"Rev Endocr Metab Disord."},{"key":"2024012713590113900_jbmr4564-bib-0006","first-page":"799","volume-title":"Prevalence, pathophysiological mechanisms and factors affecting urolithiasis [Internet]","author":"Khan","year":"2018"},{"issue":"4","key":"2024012713590113900_jbmr4564-bib-0007","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1007\/s12325-021-01649-2","article-title":"Risk of nephrolithiasis and nephrocalcinosis in patients with chronic hypoparathyroidism: a retrospective cohort study","volume":"38","author":"Ketteler","year":"2021","journal-title":"Adv Ther."},{"issue":"12","key":"2024012713590113900_jbmr4564-bib-0008","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1210\/jc.2012-1808","article-title":"Long-term follow-up of patients with hypoparathyroidism","volume":"97","author":"Mitchell","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2024012713590113900_jbmr4564-bib-0009","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology."},{"issue":"6","key":"2024012713590113900_jbmr4564-bib-0010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). 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