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We have previously reported that parathyroid hormone receptor (PTH1R) signaling in osteoprogenitors is required for normal B cell precursor differentiation, and for trafficking of maturing B cells out of the BM. Cells of the osteoblast lineage have been implicated in the regulation of several other hematopoietic cell populations, but the effects of PTH1R signaling in osteoprogenitors on other maturing hematopoietic populations have not been investigated. Here we report that numbers of maturing myeloid, T cell, and erythroid populations were increased in the BM of mice lacking PTH1R in Osx-expressing osteoprogenitors (PTH1R-OsxKO mice; knockout [KO]). This increase in maturing hematopoietic populations was not associated with an increase in progenitor populations or proliferation. The spleens of PTH1R-OsxKO mice were small with decreased numbers of all hematopoietic populations, suggesting that trafficking of mature hematopoietic populations between BM and spleen is impaired in the absence of PTH1R in osteoprogenitors. RNA sequencing (RNAseq) of osteoprogenitors and their descendants in bone and BM revealed increased expression of vascular cell adhesion protein 1 (VCAM-1) and C-X-C motif chemokine ligand 12 (CXCL12), factors that are involved in trafficking of several hematopoietic populations. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4568","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T07:08:40Z","timestamp":1651388920000},"page":"1321-1334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Loss of Parathyroid Hormone Receptor Signaling in Osteoprogenitors Is Associated With Accumulation of Multiple Hematopoietic Lineages in the Bone Marrow"],"prefix":"10.1093","volume":"37","author":[{"given":"Takaharu","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Medicine (Endocrinology) Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Panaroni","sequence":"additional","affiliation":[{"name":"Department of Medicine (Endocrinology) Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn B.","family":"Rankin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-3168","authenticated-orcid":false,"given":"Louise E.","family":"Purton","sequence":"additional","affiliation":[{"name":"The University of Melbourne Department of Medicine at St Vincent's Hospital Fitzroy VIC Australia"},{"name":"St Vincent's Institute of Medical Research Fitzroy VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-4503","authenticated-orcid":false,"given":"Joy Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medicine (Endocrinology) Stanford University School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,1]]},"reference":[{"issue":"1","key":"2024012713585398100_jbmr4568-bib-0001","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11914-014-0190-7","article-title":"Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches","volume":"12","author":"Panaroni","year":"2014","journal-title":"Curr Osteoporos Rep"},{"issue":"6960","key":"2024012713585398100_jbmr4568-bib-0002","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell 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