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Thornton Fellowship","award":["Fellowship Grant"],"award-info":[{"award-number":["Fellowship Grant"]}]},{"name":"UCLA School of Dentistry","award":["Dean's Faculty Research Seed grant"],"award-info":[{"award-number":["Dean's Faculty Research Seed grant"]}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001440","name":"ADA Foundation","doi-asserted-by":"publisher","award":["Dentsply Sirona Research Award"],"award-info":[{"award-number":["Dentsply Sirona Research Award"]}],"id":[{"id":"10.13039\/100001440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE023348"],"award-info":[{"award-number":["DE023348"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE025172"],"award-info":[{"award-number":["DE025172"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001440","name":"ADA Foundation","doi-asserted-by":"publisher","award":["Dentsply Sirona Research Award"],"award-info":[{"award-number":["Dentsply Sirona Research Award"]}],"id":[{"id":"10.13039\/100001440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a detrimental intraoral lesion that occurs in patients with long-term or high-dose use of anti-resorptive agents such as bisphosphonates. Tooth extraction is a known risk factor for BRONJ, and such intervention is often performed to eliminate existing pathological inflammatory conditions. Previously, we determined that ligature-induced periodontitis (LIP) is a risk factor for the development of osteonecrosis in mice, but it remains unclear whether the chronicity of LIP followed by extraction influences osteonecrosis development. In this study, we assess the effect of short-term and long-term LIP (ligature placed for 3\u2009weeks [S-LIP] or 10\u2009weeks [L-LIP], respectively) on osteonecrosis development in mice receiving 250\u2009\u03bcg\/kg\/week zoledronic acid (ZOL). When compared to S-LIP, L-LIP caused 70% (p\u00a0\u2264\u20090.0014) more bone loss without altering microbe composition. In the presence of ZOL, bone loss mediated by LIP was prevented and bone necrosis was induced. When the ligated tooth was extracted, histologic hallmarks of osteonecrosis including empty lacunae and necrotic bone were increased by 88% (p\u00a0=\u20090.0374) and 114% (p\u00a0=\u20090.0457), respectively, in L-LIP compared to S-LIP. We also observed significant increases in serum platelet factor 4 (PF4) and macrophage inflammatory factor 1 \u03b3 (MIP1\u03b3) in mice that received ZOL treatment and had tooth extractions compared to controls, which may be systemic markers of inflammation-associated osteonecrosis development. Additionally, CD3+ T cells were identified as the major immune population in both health and disease, and we observed a 116% (p\u00a0=\u20090.0402) increase in CD3+IL23R+ T cells in L-LIP compared to S-LIP lesions following extraction. Taken together, our study reveals that extracting a periodontally compromised tooth increases the formation of necrotic bone compared to extracting a periodontally healthy tooth and that osteonecrosis may be associated with the duration of the preexisting pathological inflammatory conditions. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4614","type":"journal-article","created":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T14:08:29Z","timestamp":1653228509000},"page":"1400-1410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Long-Term Ligature-Induced Periodontitis Exacerbates Development of Bisphosphonate-Related Osteonecrosis of the Jaw in Mice"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7718-2098","authenticated-orcid":false,"given":"Drake 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