{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:12:27Z","timestamp":1789017147761,"version":"build-2803163510"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":715,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Takeda"},{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The efficacy and safety of parathyroid hormone (PTH) therapy for managing long-term hypoparathyroidism is being evaluated in ongoing clinical trials. We undertook a systematic review and meta-analysis of currently available randomized controlled trials to investigate the benefits and harms of PTH therapy and conventional therapy in the management of patients with chronic hypoparathyroidism. To identify eligible studies, published in English, we searched Embase, PubMed, and Cochrane CENTRAL from inception to May 2022. Two reviewers independently extracted data and assessed the risk of bias. We defined patients' important outcomes and used grading of recommendations, assessment, development, and evaluation (GRADE) to provide the structure for quantifying absolute effects and rating the quality of evidence. Seven randomized trials of 12 publications that enrolled a total of 386 patients proved eligible. The follow-up duration ranged from 1 to 36\u00a0months. Compared with conventional therapy, PTH therapy probably achieves a small improvement in physical health-related quality of life (mean difference [MD] 3.4, 95% confidence interval [CI] 1.5\u20135.3, minimally important difference 3.0, moderate certainty). PTH therapy results in more patients reaching 50% or greater reduction in the dose of active vitamin D and calcium (relative risk [RR]\u00a0=\u20096.5, 95% CI 2.5\u201316.4, 385 more per 1000 patients, high certainty). PTH therapy may increase hypercalcemia (RR\u00a0=2.4, 95% CI 1.2\u20135.04, low certainty). The findings may support the use of PTH therapy in patients with chronic hypoparathyroidism. Because of limitations of short duration and small sample size, evidence from randomized trials is limited regarding important benefits of PTH therapy compared with conventional therapy. Establishing such benefits will require further studies. \u00a9 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4676","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T09:35:28Z","timestamp":1660296928000},"page":"2654-2662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Parathyroid Hormone Therapy for Managing Chronic Hypoparathyroidism: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-3136","authenticated-orcid":false,"given":"Liang","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3259-0741","authenticated-orcid":false,"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Evidence-Based Social Sciences Research Center\/Health Technology Assessment Center, School of Public Health Lanzhou University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9373-4086","authenticated-orcid":false,"given":"Meixuan","family":"Li","sequence":"additional","affiliation":[{"name":"Evidence-Based Medicine Center, School of Basic Medical Sciences Lanzhou University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9952-6058","authenticated-orcid":false,"given":"Clement","family":"Lin","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1908-7818","authenticated-orcid":false,"given":"Xu","family":"Hui","sequence":"additional","affiliation":[{"name":"Evidence-Based Social Sciences Research Center\/Health Technology Assessment Center, School of Public Health Lanzhou University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3403-720X","authenticated-orcid":false,"given":"Divyalakshmi","family":"Tamilselvan","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Department of Biochemistry and Biomedical Sciences McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1640-5999","authenticated-orcid":false,"given":"Maryam","family":"Kandi","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6135-3270","authenticated-orcid":false,"given":"Ashwini","family":"Sreekanta","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-637X","authenticated-orcid":false,"given":"Nima","family":"Makhdami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-5548","authenticated-orcid":false,"given":"Dalal S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-8419","authenticated-orcid":false,"given":"Karel","family":"Dandurand","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7864-3012","authenticated-orcid":false,"given":"Kehu","family":"Yang","sequence":"additional","affiliation":[{"name":"Evidence-Based Social Sciences Research Center\/Health Technology Assessment Center, School of Public Health Lanzhou University Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-2617","authenticated-orcid":false,"given":"John P.","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Vagelos College of Physicians and Surgeons Columbia University NY New York City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-0592","authenticated-orcid":false,"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"Fondazione Italiana sulla Ricerca sulle Malattie dell'Osso (FIRMO Foundation) Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-9546","authenticated-orcid":false,"given":"Bart L.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and NutritionMayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-9778","authenticated-orcid":false,"given":"Michael","family":"Mannstadt","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2152-4247","authenticated-orcid":false,"given":"Lars","family":"Rejnmark","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-8956","authenticated-orcid":false,"given":"Aliya A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism McMaster University Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-5718","authenticated-orcid":false,"given":"Gordon","family":"Guyatt","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"issue":"10","key":"2024012713563189200_jbmr4676-bib-0001","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research","volume":"26","author":"Bilezikian","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2024012713563189200_jbmr4676-bib-0002","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s12020-012-9618-y","article-title":"Mini-review: new therapeutic options in hypoparathyroidism","volume":"41","author":"Cusano","year":"2012","journal-title":"Endocrine."},{"issue":"4","key":"2024012713563189200_jbmr4676-bib-0003","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. Hypoparathyroidism","volume":"359","author":"Shoback","year":"2008","journal-title":"N Engl J Med."},{"issue":"12","key":"2024012713563189200_jbmr4676-bib-0004","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1210\/jc.2012-1808","article-title":"Long-term follow-up of patients with hypoparathyroidism","volume":"97","author":"Mitchell","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"2","key":"2024012713563189200_jbmr4676-bib-0005","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1530\/EJE-18-0541","article-title":"Management of endocrine disease: hypoparathyroidism in pregnancy: review and evidence-based recommendations for management","volume":"180","author":"Khan","year":"2019","journal-title":"Eur J Endocrinol."},{"key":"2024012713563189200_jbmr4676-bib-0006"},{"issue":"2","key":"2024012713563189200_jbmr4676-bib-0007","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-15-0628","article-title":"European Society of Endocrinology Clinical Guideline: treatment of chronic hypoparathyroidism in adults","volume":"173","author":"Bollerslev","year":"2015","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"2024012713563189200_jbmr4676-bib-0008","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4158\/EP14462.DSC","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology Disease State clinical review: postoperative hypoparathyroidism\u2014definitions and management","volume":"21","author":"Stack","year":"2015","journal-title":"Endocr Pract."},{"issue":"11","key":"2024012713563189200_jbmr4676-bib-0009","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/bjs.7219","article-title":"Outcome of protracted hypoparathyroidism after total thyroidectomy","volume":"97","author":"Sitges-Serra","year":"2010","journal-title":"Br J Surg."},{"issue":"6","key":"2024012713563189200_jbmr4676-bib-0010","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1210\/jc.2015-3907","article-title":"Management of hypoparathyroidism: summary statement and guidelines","volume":"101","author":"Brandi","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"2024012713563189200_jbmr4676-bib-0011","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/jbmr.4016","article-title":"A randomized double-blind placebo-controlled first-in-human phase 1 trial of TransCon PTH in healthy adults","volume":"35","author":"Karpf","year":"2020","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2024012713563189200_jbmr4676-bib-0012","doi-asserted-by":"crossref","first-page":"e372","DOI":"10.1210\/clinem\/dgab577","article-title":"PaTH forward: a randomized, double-blind, placebo-controlled phase 2 trial of TransCon PTH in adult hypoparathyroidism","volume":"107","author":"Khan","year":"2022","journal-title":"J Clin Endocrinol Metab."},{"key":"2024012713563189200_jbmr4676-bib-0013","author":"Khan","year":"2022"},{"issue":"4","key":"2024012713563189200_jbmr4676-bib-0014","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00198-020-05718-0","article-title":"Long-term cancer surveillance: results from the Forteo Patient Registry Surveillance Study","volume":"32","author":"Gilsenan","year":"2021","journal-title":"Osteoporos Int."},{"issue":"3","key":"2024012713563189200_jbmr4676-bib-0015","doi-asserted-by":"crossref","first-page":"p1","DOI":"10.1530\/EJE-18-0609","article-title":"Standards of care for hypoparathyroidism in adults: a Canadian and international consensus","volume":"180","author":"Khan","year":"2019","journal-title":"Eur J Endocrinol."},{"issue":"7","key":"2024012713563189200_jbmr4676-bib-0016","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"key":"2024012713563189200_jbmr4676-bib-0017","first-page":"Cd012845","article-title":"Calcium, vitamin D or recombinant parathyroid hormone for managing post-thyroidectomy hypoparathyroidism","volume":"5","author":"Edafe","year":"2019","journal-title":"Cochrane Database Syst Rev."},{"key":"2024012713563189200_jbmr4676-bib-0018","article-title":"The complications, symptoms in adult patients with chronic hypoparathyroidism: a systematic review","author":"Yao","year":"2021","journal-title":"J Bone Miner Res."},{"key":"2024012713563189200_jbmr4676-bib-0019","author":"Higgins"},{"key":"2024012713563189200_jbmr4676-bib-0020","author":"Guyatt"},{"issue":"7650","key":"2024012713563189200_jbmr4676-bib-0021","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ."},{"issue":"7651","key":"2024012713563189200_jbmr4676-bib-0022","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/bmj.39490.551019.BE","article-title":"What is \u201cquality of evidence\u201d and why is it important to clinicians?","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ."},{"key":"2024012713563189200_jbmr4676-bib-0023","author":"Deeks"},{"issue":"1","key":"2024012713563189200_jbmr4676-bib-0024","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12020-016-1141-0","article-title":"Effects of parathyroid hormone rhPTH(1\u201384) on phosphate homeostasis and vitamin D metabolism in hypoparathyroidism: REPLACE phase 3 study","volume":"55","author":"Clarke","year":"2016","journal-title":"Endocrine."},{"issue":"4","key":"2024012713563189200_jbmr4676-bib-0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S2213-8587(13)70106-2","article-title":"Efficacy and safety of recombinant human parathyroid hormone (1\u201384) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study","volume":"1","author":"Mannstadt","year":"2013","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"10","key":"2024012713563189200_jbmr4676-bib-0026","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1002\/jbmr.1964","article-title":"PTH(1-84) replacement therapy in hypoparathyroidism: a randomized controlled trial on pharmacokinetic and dynamic effects after 6 months of treatment","volume":"28","author":"Sikjaer","year":"2013","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2024012713563189200_jbmr4676-bib-0027","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1002\/jbmr.470","article-title":"The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study","volume":"26","author":"Sikjaer","year":"2011","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2024012713563189200_jbmr4676-bib-0028","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/jbmr.1493","article-title":"Changes in 3-dimensional bone structure indices in hypoparathyroid patients treated with PTH(1-84): a randomized controlled study","volume":"27","author":"Sikjaer","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2024012713563189200_jbmr4676-bib-0029","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00198-014-2677-6","article-title":"Effects of PTH(1\u201384) therapy on muscle function and quality of life in hypoparathyroidism: results from a randomized controlled trial","volume":"25","author":"Sikjaer","year":"2014","journal-title":"Osteoporos Int."},{"issue":"2","key":"2024012713563189200_jbmr4676-bib-0030","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1210\/jc.2017-01471","article-title":"Recombinant human parathyroid hormone effect on health-related quality of life in adults with chronic hypoparathyroidism","volume":"103","author":"Vokes","year":"2018","journal-title":"J Clin Endocrinol Metabol."},{"issue":"9","key":"2024012713563189200_jbmr4676-bib-0031","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1210\/jc.2002-021736","article-title":"Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone-(1\u201334) versus calcitriol and calcium","volume":"88","author":"Winer","year":"2003","journal-title":"J Clin Endocrinol Metabol."},{"issue":"8","key":"2024012713563189200_jbmr4676-bib-0032","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1001\/jama.1996.03540080053029","article-title":"Synthetic human parathyroid hormone 1-34 vs calcitriol and calcium in the treatment of hypoparathyroidism","volume":"276","author":"Winer","year":"1996","journal-title":"JAMA."},{"issue":"6","key":"2024012713563189200_jbmr4676-bib-0033","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1210\/jc.2009-2464","article-title":"Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1-34 versus calcitriol and calcium","volume":"95","author":"Winer","year":"2010","journal-title":"J Clin Endocrinol Metab."},{"key":"2024012713563189200_jbmr4676-bib-0034","volume-title":"User's manual for the SF-36v2 health survey","author":"Ware","year":"2007","edition":"2nd ed"},{"key":"2024012713563189200_jbmr4676-bib-0035","doi-asserted-by":"crossref","first-page":"115977","DOI":"10.1016\/j.bone.2021.115977","article-title":"Therapy with PTH 1-34 or calcitriol and calcium in diverse etiologies of hypoparathyroidism over 27\u2009years at a single tertiary care center","volume":"149","author":"Winer","year":"2021","journal-title":"Bone."},{"issue":"2","key":"2024012713563189200_jbmr4676-bib-0036","doi-asserted-by":"crossref","first-page":"206","DOI":"10.4103\/ijem.IJEM_579_19","article-title":"Parathyroid hormone replacement versus oral calcium and active vitamin D supplementation in hypoparathyroidism: a meta-analysis","volume":"24","author":"Palui","year":"2020","journal-title":"Indian J Endocrinol Metab."},{"issue":"6","key":"2024012713563189200_jbmr4676-bib-0037","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1055\/s-0042-106970","article-title":"Parathyroid hormone replacement therapy in hypoparathyroidism: a meta-analysis","volume":"48","author":"Liu","year":"2016","journal-title":"Horm Metab Res."}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4676","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/12\/2654\/55455615\/jbmr4676.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/37\/12\/2654\/55455615\/jbmr4676.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:45:55Z","timestamp":1710326755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/37\/12\/2654-2662\/7500031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,8,12]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4676","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4676\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4676\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4676\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4676\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4676\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4676\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2022-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}