{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:58Z","timestamp":1786978078589,"version":"build-2736575974"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":716,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Health Commission","award":["201840077"],"award-info":[{"award-number":["201840077"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802120"],"award-info":[{"award-number":["81802120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972076"],"award-info":[{"award-number":["81972076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072394"],"award-info":[{"award-number":["82072394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802120"],"award-info":[{"award-number":["81802120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972076"],"award-info":[{"award-number":["81972076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072394"],"award-info":[{"award-number":["82072394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004921","name":"Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteogenesis imperfecta (OI) is a genetic disorder caused by mutations of type I collagen-related genes, and excessive transforming growth factor-beta (TGF-\u03b2) signaling is a common mechanism. TGF-\u03b2\/Smad signaling has inhibitory effects on osteoblast differentiation and maturation and is mainly transduced and regulated by the internalization of a tetrameric receptor complex comprising types I and II TGF-\u03b2 receptors (T\u03b2RI and T\u03b2RII). During internalization, clathrin-mediated endocytosis enhances TGF-\u03b2\/Smad signaling via Smad2\/3 phosphorylation and receptors recycling, while caveolae-mediated endocytosis turns off TGF-\u03b2\/Smad signaling by promoting receptor ubiquitination and degradation. In this study, using an animal model of OI (Colla2oim, osteogenesis imperfecta murine [oim]\/oim mouse), we found that osteoblastic cells of oim\/oim mice were more sensitive to the inhibitory effects of TGF-\u03b2 on osteoblast differentiation and maturation and had much higher cell membrane protein levels of TGF-\u03b2 receptors than those of wild-type (wt)\/wt mice. Further results showed that clathrin-mediated endocytosis of T\u03b2RI was enhanced, whereas caveolae-mediated T\u03b2RI endocytic degradation was reduced in oim\/oim mice, combined with reduced caveolin-1 (Cav-1) phosphorylation. In addition, type I collagen downregulated T\u03b2RI via focal adhesion kinase (FAK) and Src activation-dependent Cav-1 phosphorylation. To further examine this mechanism, 4-week-old oim\/oim and wt\/wt mice were treated with either T\u03b2RI kinase inhibitor (SD-208) or vehicle for 8\u2009weeks. SD-208 treatment significantly reduced the fracture incidence in oim\/oim mice. Micro\u2013computed tomography and biomechanical testing showed that femoral bone mass and strength were significantly improved with SD-208 treatment in both genotypes. Additionally, SD-208 significantly promoted osteoblast differentiation and bone formation and inhibited bone resorption. In conclusion, dysfunction of caveolae-mediated endocytic T\u03b2RI degradation is a possible mechanism for the enhanced TGF-\u03b2\/Smad signaling in OI. Targeting this mechanism using a T\u03b2RI kinase inhibitor effectively reduced fractures and improved bone mass and strength in OI model and, thus, may offer a new strategy for the treatment of OI. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>\n                  <jats:p>Abstract<\/jats:p>\n                  <jats:p>In this study, we found that caveolae-mediated endocytic T\u03b2RI degradation was reduced in OI due to the impaired regulation of type I collagen on FAK\/Src activation-dependent Caveolin-1 phosphorylation, which further enhanced the TGF-\u03b2\/Smad signaling on the inhibition of osteoblast differentiation. Inhibition of T\u03b2RI kinase by SD-208 effectively reduced fractures and improved bone mass and strength in an OI mouse model.<\/jats:p>","DOI":"10.1002\/jbmr.4734","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T08:54:23Z","timestamp":1667379263000},"page":"103-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dysfunction of Caveolae-Mediated Endocytic T\u03b2RI Degradation Results in Hypersensitivity of TGF-\u03b2\/Smad Signaling in Osteogenesis Imperfecta"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-928X","authenticated-orcid":false,"given":"Changgui","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lecheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Orthopedics and Traumatology, Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwei","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Orthopedics and Traumatology, Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhai","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Changzheng Hospital Naval Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"issue":"10028","key":"2024012714082767100_jbmr4734-bib-0001","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta","volume":"387","author":"Forlino","year":"2016","journal-title":"Lancet"},{"key":"2024012714082767100_jbmr4734-bib-0002","doi-asserted-by":"crossref","first-page":"17052","DOI":"10.1038\/nrdp.2017.52","article-title":"Osteogenesis imperfecta","volume":"3","author":"Marini","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0003","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jped.2014.05.003","article-title":"What is new in genetics and osteogenesis imperfecta classification?","volume":"90","author":"Valadares","year":"2014","journal-title":"J Pediatr"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0004","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/MOP.0000000000000813","article-title":"Osteogenesis imperfecta: advancements in genetics and treatment","volume":"31","author":"Rossi","year":"2019","journal-title":"Curr Opin Pediatr"},{"issue":"4","key":"2024012714082767100_jbmr4734-bib-0005","doi-asserted-by":"crossref","first-page":"R95","DOI":"10.1530\/EJE-20-0299","article-title":"Osteogenesis imperfecta: an update on clinical features and therapies","volume":"183","author":"Marom","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2024012714082767100_jbmr4734-bib-0006","doi-asserted-by":"crossref","first-page":"e10174","DOI":"10.1002\/jbm4.10174","article-title":"Osteogenesis imperfecta: new perspectives from clinical and translational research","volume":"3","author":"Tauer","year":"2019","journal-title":"JBMR Plus"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0007","doi-asserted-by":"crossref","first-page":"e10118","DOI":"10.1002\/jbm4.10118","article-title":"A multicenter observational cohort study to evaluate the effects of bisphosphonate exposure on bone mineral density and other health outcomes in osteogenesis imperfecta","volume":"3","author":"Bains","year":"2019","journal-title":"JBMR Plus"},{"issue":"10","key":"2024012714082767100_jbmr4734-bib-0008","first-page":"Cd005088","article-title":"Bisphosphonate therapy for osteogenesis imperfecta","volume":"10","author":"Dwan","year":"2016","journal-title":"Cochrane Database Syst. Rev"},{"issue":"3","key":"2024012714082767100_jbmr4734-bib-0009","doi-asserted-by":"crossref","first-page":"e894","DOI":"10.1097\/MJT.0000000000000236","article-title":"Efficacy of bisphosphonates on bone mineral density and fracture rate in patients with osteogenesis imperfecta: a systematic review and meta-analysis","volume":"23","author":"Shi","year":"2016","journal-title":"Am J Ther"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s11914-017-0401-0","article-title":"Long-term bisphosphonate therapy in osteogenesis imperfecta","volume":"15","author":"Biggin","year":"2017","journal-title":"Curr Osteoporos Rep"},{"issue":"12","key":"2024012714082767100_jbmr4734-bib-0011","doi-asserted-by":"crossref","DOI":"10.3390\/jcm7120479","article-title":"Efficacy and safety of denosumab therapy for osteogenesis imperfecta patients with osteoporosis-case series","volume":"7","author":"Kobayashi","year":"2018","journal-title":"J Clin Med"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0012","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/jbmr.3110","article-title":"Clinical features of 24 patients with rebound-associated vertebral fractures after denosumab discontinuation: systematic review and additional cases","volume":"32","author":"Anastasilakis","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0013","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI71101","article-title":"Evaluation of teriparatide treatment in adults with osteogenesis imperfecta","volume":"124","author":"Orwoll","year":"2014","journal-title":"J Clin Invest"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0014","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1359\/jbmr.080208","article-title":"On the interpretation of rat carcinogenicity studies for human PTH(1-34) and human PTH(1-84)","volume":"23","author":"Tashjian","year":"2008","journal-title":"J Bone Miner Res"},{"key":"2024012714082767100_jbmr4734-bib-0015","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/boneres.2016.9","article-title":"TGF-\u03b2 and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease","volume":"4","author":"Wu","year":"2016","journal-title":"Bone Res"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0016","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7150\/ijbs.2929","article-title":"TGF-\u03b2 and BMP signaling in osteoblast differentiation and bone formation","volume":"8","author":"Chen","year":"2012","journal-title":"Int J Biol Sci"},{"issue":"7","key":"2024012714082767100_jbmr4734-bib-0017","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nm.1979","article-title":"TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation","volume":"15","author":"Tang","year":"2009","journal-title":"Nat Med"},{"issue":"9","key":"2024012714082767100_jbmr4734-bib-0018","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1093\/emboj\/20.9.2254","article-title":"TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation","volume":"20","author":"Alliston","year":"2001","journal-title":"EMBO J"},{"issue":"7","key":"2024012714082767100_jbmr4734-bib-0019","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152571","article-title":"Targeting TGF-\u03b2 for treatment of osteogenesis imperfecta","volume":"132","author":"Song","year":"2022","journal-title":"J Clin Invest"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0020","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nm.3544","article-title":"Excessive transforming growth factor-\u03b2 signaling is a common mechanism in osteogenesis imperfecta","volume":"20","author":"Grafe","year":"2014","journal-title":"Nat Med"},{"issue":"9","key":"2024012714082767100_jbmr4734-bib-0021","doi-asserted-by":"crossref","first-page":"e10530","DOI":"10.1002\/jbm4.10530","article-title":"Inhibition of TGF-\u03b2 increases bone volume and strength in a mouse model of Osteogenesis Imperfecta","volume":"5","author":"Greene","year":"2021","journal-title":"JBMR Plus"},{"key":"2024012714082767100_jbmr4734-bib-0022","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cellsig.2018.09.002","article-title":"TGF-\u03b2 receptors: In and beyond TGF-\u03b2 signaling","volume":"52","author":"Vander Ark","year":"2018","journal-title":"Cell Signal"},{"issue":"3","key":"2024012714082767100_jbmr4734-bib-0023","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/sj.emboj.7600067","article-title":"Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells","volume":"23","author":"Maeda","year":"2004","journal-title":"EMBO J"},{"issue":"4","key":"2024012714082767100_jbmr4734-bib-0024","doi-asserted-by":"crossref","first-page":"e5275","DOI":"10.1371\/journal.pone.0005275","article-title":"Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone","volume":"4","author":"Mohammad","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"2024012714082767100_jbmr4734-bib-0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000055910","article-title":"Increased cell surface expression of receptors for transforming growth factor-beta on osteoblasts from patients with Osteogenesis imperfecta","volume":"68","author":"Gebken","year":"2000","journal-title":"Pathobiology"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0026","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jbmr.3617","article-title":"Effect of anti-TGF-\u03b2 treatment in a mouse model of severe osteogenesis imperfecta","volume":"34","author":"Tauer","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024012714082767100_jbmr4734-bib-0027","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/abbs\/gmx119","article-title":"Intracellular trafficking of transforming growth factor \u03b2 receptors","volume":"50","author":"Yakymovych","year":"2018","journal-title":"Acta Biochim Biophys Sin"},{"issue":"1","key":"2024012714082767100_jbmr4734-bib-0028","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/cr.2008.315","article-title":"Endocytic regulation of TGF-beta signaling","volume":"19","author":"Chen","year":"2009","journal-title":"Cell Res"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0029","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1073\/pnas.90.5.1701","article-title":"Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta","volume":"90","author":"Chipman","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0030","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2144\/96212bm03","article-title":"PCR genotyping of oim mutant mice","volume":"21","author":"Saban","year":"1996","journal-title":"Biotechniques"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0031","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bbadis.2017.11.015","article-title":"Altered TGF-\u03b2 endocytic trafficking contributes to the increased signaling in Marfan syndrome","volume":"1864","author":"Siegert","year":"2018","journal-title":"Biochim Biophys Acta, Mol Basis Dis"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0032","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbamcr.2011.01.028","article-title":"The TGF-\u03b2 co-receptor, CD109, promotes internalization and degradation of TGF-\u03b2 receptors","volume":"1813","author":"Bizet","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"2024012714082767100_jbmr4734-bib-0033","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1091\/mbc.e08-09-0898","article-title":"Specific activation of mitogen-activated protein kinase by transforming growth factor-beta receptors in lipid rafts is required for epithelial cell plasticity","volume":"20","author":"Zuo","year":"2009","journal-title":"Mol Biol Cell"},{"key":"2024012714082767100_jbmr4734-bib-0034","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-1-4939-7113-8_19","article-title":"Collagen purification from rat tail tendons","volume":"1627","author":"Ritti\u00e9","year":"2017","journal-title":"Methods Mol Biol"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0035","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/jbmr.2770","article-title":"Strontium Ranelate reduces the fracture incidence in a growing mouse model of Osteogenesis Imperfecta","volume":"31","author":"Shi","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"1","key":"2024012714082767100_jbmr4734-bib-0036","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry nomenclature committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2024012714082767100_jbmr4734-bib-0037","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.1074\/jbc.M008340200","article-title":"Caveolin-1 regulates transforming growth factor (TGF)-beta\/SMAD signaling through an interaction with the TGF-beta type I receptor","volume":"276","author":"Razani","year":"2001","journal-title":"J Biol Chem"},{"issue":"10","key":"2024012714082767100_jbmr4734-bib-0038","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/cr.2012.92","article-title":"PICK1 promotes caveolin-dependent degradation of TGF-\u03b2 type I receptor","volume":"22","author":"Zhao","year":"2012","journal-title":"Cell Res"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0039","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S1097-2765(00)00134-9","article-title":"Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation","volume":"6","author":"Kavsak","year":"2000","journal-title":"Mol Cell"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0040","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1582-4934.2007.00127.x","article-title":"Tyrosine phosphorylation-dependence of caveolae-mediated endocytosis","volume":"11","author":"Sverdlov","year":"2007","journal-title":"J Cell Mol Med"},{"issue":"13","key":"2024012714082767100_jbmr4734-bib-0041","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1091\/mbc.E15-11-0756","article-title":"Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae","volume":"27","author":"Zimnicka","year":"2016","journal-title":"Mol Biol Cell"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0042","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.2353\/ajpath.2010.090704","article-title":"Immature osteoblast lineage cells increase osteoclastogenesis in osteogenesis imperfecta murine","volume":"176","author":"Li","year":"2010","journal-title":"Am J Pathol"},{"issue":"1\u20132","key":"2024012714082767100_jbmr4734-bib-0043","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1083\/jcb.132.1.195","article-title":"Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype","volume":"132","author":"Erlebacher","year":"1996","journal-title":"J Cell Biol"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0044","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1359\/jbmr.2002.17.2.240","article-title":"Stimulation of Smad1 transcriptional activity by Ras-extracellular signal-regulated kinase pathway: a possible mechanism for collagen-dependent osteoblastic differentiation","volume":"17","author":"Suzawa","year":"2002","journal-title":"J Bone Miner Res"},{"issue":"46","key":"2024012714082767100_jbmr4734-bib-0045","doi-asserted-by":"crossref","first-page":"29309","DOI":"10.1074\/jbc.272.46.29309","article-title":"Differentiation and transforming growth factor-beta receptor down-regulation by collagen-alpha2beta1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells","volume":"272","author":"Takeuchi","year":"1997","journal-title":"J Biol Chem"},{"issue":"3","key":"2024012714082767100_jbmr4734-bib-0046","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ncb2022","article-title":"TGF-beta type II receptor phosphorylates PTH receptor to integrate bone remodelling signalling","volume":"12","author":"Qiu","year":"2010","journal-title":"Nat Cell Biol"},{"issue":"13","key":"2024012714082767100_jbmr4734-bib-0047","doi-asserted-by":"crossref","first-page":"12239","DOI":"10.1074\/jbc.M413284200","article-title":"Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling","volume":"280","author":"Zhang","year":"2005","journal-title":"J Biol Chem"},{"issue":"2","key":"2024012714082767100_jbmr4734-bib-0048","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1083\/jcb.200612046","article-title":"The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor","volume":"178","author":"Atfi","year":"2007","journal-title":"J Cell Biol"},{"issue":"13","key":"2024012714082767100_jbmr4734-bib-0049","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1084\/jem.20061536","article-title":"Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis","volume":"203","author":"Wang","year":"2006","journal-title":"J Exp Med"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0050","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/BOR.0b013e3283103d27","article-title":"Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis","volume":"20","author":"Del Galdo","year":"2008","journal-title":"Curr Opin Rheumatol"},{"issue":"6","key":"2024012714082767100_jbmr4734-bib-0051","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1083\/jcb.108.6.2401","article-title":"Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton","volume":"108","author":"Glenney","year":"1989","journal-title":"J Cell Biol"},{"issue":"16","key":"2024012714082767100_jbmr4734-bib-0052","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1091\/mbc.e17-05-0278","article-title":"The phospho-caveolin-1 scaffolding domain dampens force fluctuations in focal adhesions and promotes cancer cell migration","volume":"28","author":"Meng","year":"2017","journal-title":"Mol Biol Cell"},{"issue":"4","key":"2024012714082767100_jbmr4734-bib-0053","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/cvr\/cvm097","article-title":"Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolae","volume":"77","author":"Santibanez","year":"2008","journal-title":"Cardiovasc Res"},{"issue":"12","key":"2024012714082767100_jbmr4734-bib-0054","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1002\/jbmr.1992","article-title":"Hyperactive transforming growth factor-\u03b21 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model","volume":"28","author":"Rhodes","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0055","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s00223-019-00655-5","article-title":"Sclerostin-antibody treatment decreases fracture rates in axial skeleton and improves the skeletal phenotype in growing oim\/oim mice","volume":"106","author":"Cardinal","year":"2020","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2024012714082767100_jbmr4734-bib-0056","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1210\/endo.143.5.8807","article-title":"Osteoblastic response to the defective matrix in the osteogenesis imperfecta murine (oim) mouse","volume":"143","author":"Kalajzic","year":"2002","journal-title":"Endocrinology"},{"issue":"1","key":"2024012714082767100_jbmr4734-bib-0057","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/cr.2008.302","article-title":"Signaling cross-talk between TGF-beta\/BMP and other pathways","volume":"19","author":"Guo","year":"2009","journal-title":"Cell Res"},{"issue":"1","key":"2024012714082767100_jbmr4734-bib-0058","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00280-019-03979-z","article-title":"Population pharmacokinetics of vactosertib, a new TGF-\u03b2 receptor type \u0399 inhibitor, in patients with advanced solid tumors","volume":"85","author":"Jung","year":"2020","journal-title":"Cancer Chemother Pharmacol"},{"issue":"7","key":"2024012714082767100_jbmr4734-bib-0059","doi-asserted-by":"crossref","first-page":"e00056","DOI":"10.14309\/ctg.0000000000000056","article-title":"A phase 2 study of galunisertib (TGF-\u03b21 receptor type I inhibitor) and sorafenib in patients with advanced hepatocellular carcinoma","volume":"10","author":"Kelley","year":"2019","journal-title":"Clin Transl Gastroenterol"},{"issue":"3","key":"2024012714082767100_jbmr4734-bib-0060","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/onc.2015.100","article-title":"Syntenin regulates TGF-\u03b21-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-\u03b2 type I receptor internalization","volume":"35","author":"Hwangbo","year":"2016","journal-title":"Oncogene"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/1\/103\/55455152\/jbmr4734.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/1\/103\/55455152\/jbmr4734.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:46:32Z","timestamp":1710326792000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/38\/1\/103-118\/7499947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,11,2]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4734","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4734\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4734\/v1\/review3","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2022-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}