{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:16:58Z","timestamp":1790914618058,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":722,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant of Keio Orthopaedic Hosoya Foundation","award":["no.007"],"award-info":[{"award-number":["no.007"]}]},{"name":"JSPS KAKENHI Grant","award":["no. 18H02931"],"award-info":[{"award-number":["no. 18H02931"]}]},{"name":"JSPS KAKENHI Grant","award":["no. 19H03787"],"award-info":[{"award-number":["no. 19H03787"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency For Medical Research and Development","doi-asserted-by":"publisher","award":["22ek0109486h0003"],"award-info":[{"award-number":["22ek0109486h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["22ek0109486h0003"],"award-info":[{"award-number":["22ek0109486h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adolescent idiopathic scoliosis (AIS) is a serious health problem affecting 3% of live births all over the world. Many loci associated with AIS have been identified by previous genome wide association studies, but their biological implication remains mostly unclear. In this study, we evaluated the AIS-associated variants in the 7p22.3 locus by combining in silico, in vitro, and in vivo analyses. rs78148157 was located in an enhancer of UNCX, a homeobox gene and its risk allele upregulated the UNCX expression. A transcription factor, early growth response 1 (EGR1), transactivated the rs78148157-located enhancer and showed a higher binding affinity for the risk allele of rs78148157. Furthermore, zebrafish larvae with UNCX messenger RNA (mRNA) injection developed body curvature and defective neurogenesis in a dose-dependent manner. rs78148157 confers the genetic susceptibility to AIS by enhancing the EGR1-regulated UNCX expression. \u00a9 2022 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4738","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T08:08:41Z","timestamp":1667808521000},"page":"144-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Identification of a Functional Susceptibility Variant for Adolescent Idiopathic Scoliosis that Upregulates Early Growth Response 1 (EGR1)-Mediated UNCX Expression"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3004-1711","authenticated-orcid":false,"given":"Yoshiro","family":"Yonezawa","sequence":"first","affiliation":[{"name":"Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Sciences Tokyo Japan"},{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-6941","authenticated-orcid":false,"given":"Long","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Science, School of Basic Medical Sciences Xi\u2019an Jiaotong University Xi\u2019an China"},{"name":"Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaya","family":"Kakinuma","sequence":"additional","affiliation":[{"name":"Laboratory for Neural Circuit Dynamics of Decision Making RIKEN Brain Science Institute Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Otomo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Shiraki","sequence":"additional","affiliation":[{"name":"Laboratory for Neural Circuit Dynamics of Decision Making RIKEN Brain Science Institute Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Graduate School of Medical Sciences Hokkaido University Sapporo Japan"},{"name":"Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohei","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Seirei Sakura Citizen Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Hospital Organization, Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Meijo Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Hospital Organization Hokkaido Medical Center Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuho","family":"Yonezawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Niigata University Medical and Dental General Hospital Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaito","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Yanagida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Fukuoka Children's Hospital Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Taneichi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Dokkyo Medical University School of Medicine Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Harimaya","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kyushu University Beppu Hospital Beppu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic, Surgery, Faculty of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Shigematsu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Nara Medical University Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Dokkyo Medical University Koshigaya Hospital Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Demura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kanazawa University Hospital Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Jichi Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Fujita Health University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eijiro","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naobumi","family":"Hosogane","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuki","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kono Orthopaedic Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Chiba","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Defense Medical College Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Seirei Sakura Citizen Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Seirei Sakura Citizen Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Seirei Sakura Citizen Hospital Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery National Hospital Organization, Kobe Medical Center Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Kakutani","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Meijo Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Sudo","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine for Spine and Spinal Cord Disorders Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Preventive and Therapeutic Research for Metastatic Bone Tumor, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Juntendo University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Inami","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Dokkyo Medical University School of Medicine Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morio","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-4095","authenticated-orcid":false,"given":"Chikashi","family":"Terao","sequence":"additional","affiliation":[{"name":"Laboratory for Statistical and Translational Genetics RIKEN Center for Integrative Medical Sciences Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Laboratory for Neural Circuit Dynamics of Decision Making RIKEN Brain Science Institute Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Ikegawa","sequence":"additional","affiliation":[{"name":"Laboratory for Bone and Joint Diseases RIKEN Center for Integrative Medical Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"2024012714084956600_jbmr4738-bib-0001","first-page":"43","article-title":"Scoliosis prevalence: a call for a statement of terms","volume":"126","author":"Kane","year":"1977","journal-title":"Clin Orthop Relat Res"},{"issue":"24","key":"2024012714084956600_jbmr4738-bib-0002","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1097\/00007632-199912150-00006","article-title":"Natural history","volume":"24","author":"Weinstein","year":"1999","journal-title":"Spine"},{"issue":"8","key":"2024012714084956600_jbmr4738-bib-0003","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/jbmr.4324","article-title":"Polygenic risk score of adolescent idiopathic scoliosis for potential clinical use","volume":"36","author":"Otomo","year":"2021","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2024012714084956600_jbmr4738-bib-0004","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00586-011-2074-1","article-title":"Heritability of scoliosis","volume":"21","author":"Grauers","year":"2012","journal-title":"Eur Spine J"},{"key":"2024012714084956600_jbmr4738-bib-0005","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ebiom.2018.09.014","article-title":"Value of DNA methylation in predicting curve progression in patients with adolescent idiopathic scoliosis","volume":"36","author":"Meng","year":"2018","journal-title":"EBioMedicine"},{"key":"2024012714084956600_jbmr4738-bib-0006","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fbioe.2019.00364","article-title":"Whole-genome methylation analysis of phenotype discordant monozygotic twins reveals novel epigenetic perturbation contributing to the pathogenesis of adolescent idiopathic scoliosis","volume":"7","author":"Liu","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"issue":"12","key":"2024012714084956600_jbmr4738-bib-0007","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/ng.974","article-title":"A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis","volume":"43","author":"Takahashi","year":"2011","journal-title":"Nat Genet"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0008","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1038\/s41598-018-22552-x","article-title":"An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis","volume":"8","author":"Ogura","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0009","doi-asserted-by":"crossref","first-page":"11575","DOI":"10.1038\/s41598-018-29011-7","article-title":"A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis","volume":"8","author":"Kou","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0010","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/s41467-019-11596-w","article-title":"Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese","volume":"10","author":"Kou","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0011","doi-asserted-by":"crossref","first-page":"e1005802","DOI":"10.1371\/journal.pgen.1005802","article-title":"Functional investigation of a non-coding variant associated with adolescent idiopathic scoliosis in zebrafish: elevated expression of the ladybird Homeobox gene causes body Axis deformation","volume":"12","author":"Guo","year":"2016","journal-title":"PLoS Genet"},{"issue":"2","key":"2024012714084956600_jbmr4738-bib-0012","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ajhg.2015.06.012","article-title":"A functional SNP in BNC2 is associated with adolescent idiopathic scoliosis","volume":"97","author":"Ogura","year":"2015","journal-title":"Am J Hum Genet"},{"issue":"6","key":"2024012714084956600_jbmr4738-bib-0013","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng.2639","article-title":"Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis","volume":"45","author":"Kou","year":"2013","journal-title":"Nat Genet"},{"issue":"15","key":"2024012714084956600_jbmr4738-bib-0014","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1093\/hmg\/ddv170","article-title":"Gpr126\/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice","volume":"24","author":"Karner","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"21","key":"2024012714084956600_jbmr4738-bib-0015","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.cub.2016.08.026","article-title":"Intraspinal sensory neurons provide powerful inhibition to motor circuits ensuring postural control during locomotion","volume":"26","author":"Hubbard","year":"2016","journal-title":"Curr Biol"},{"issue":"6291","key":"2024012714084956600_jbmr4738-bib-0016","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.aaf6419","article-title":"Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature","volume":"352","author":"Grimes","year":"2016","journal-title":"Science"},{"issue":"9","key":"2024012714084956600_jbmr4738-bib-0017","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1093\/nar\/19.9.2499","article-title":"A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells","volume":"19","author":"Andrews","year":"1991","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"2024012714084956600_jbmr4738-bib-0018","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.ajhg.2018.03.001","article-title":"An osteoporosis risk SNP at 1p36.12 acts as an allele-specific enhancer to modulate LINC00339 expression via long-range loop formation","volume":"102","author":"Chen","year":"2018","journal-title":"Am J Hum Genet"},{"issue":"12","key":"2024012714084956600_jbmr4738-bib-0019","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nmeth.3630","article-title":"Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements","volume":"12","author":"Thakore","year":"2015","journal-title":"Nat Methods"},{"key":"2024012714084956600_jbmr4738-bib-0020","first-page":"e60575","article-title":"Whole mount immunohistochemistry in zebrafish embryos and larvae","volume":"155","author":"Hammond-Weinberger","year":"2020","journal-title":"J Visualized Exp"},{"key":"2024012714084956600_jbmr4738-bib-0021","doi-asserted-by":"crossref","first-page":"100011","DOI":"10.1016\/j.gene.2019.100011","article-title":"Characterization of paralogous uncx transcription factor encoding genes in zebrafish","volume":"2","author":"Nittoli","year":"2019","journal-title":"Gene"},{"issue":"8","key":"2024012714084956600_jbmr4738-bib-0022","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41576-019-0127-1","article-title":"Benefits and limitations of genome-wide association studies","volume":"20","author":"Tam","year":"2019","journal-title":"Nat Rev Genet"},{"key":"2024012714084956600_jbmr4738-bib-0023","doi-asserted-by":"crossref","first-page":"6452","DOI":"10.1038\/ncomms7452","article-title":"A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females","volume":"6","author":"Sharma","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"2024012714084956600_jbmr4738-bib-0024","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ydbio.2009.02.023","article-title":"Cyclical expression of the notch\/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis","volume":"329","author":"Sewell","year":"2009","journal-title":"Dev Biol"},{"issue":"2","key":"2024012714084956600_jbmr4738-bib-0025","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.ydbio.2009.06.006","article-title":"Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton","volume":"332","author":"Skuntz","year":"2009","journal-title":"Dev Biol"},{"issue":"11","key":"2024012714084956600_jbmr4738-bib-0026","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1242\/dev.127.11.2259","article-title":"The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column","volume":"127","author":"Leitges","year":"2000","journal-title":"Development"},{"key":"2024012714084956600_jbmr4738-bib-0027","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1038\/ncomms5777","article-title":"ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease","volume":"5","author":"Hayes","year":"2014","journal-title":"Nat Commun"},{"issue":"11","key":"2024012714084956600_jbmr4738-bib-0028","doi-asserted-by":"crossref","first-page":"e1007817","DOI":"10.1371\/journal.pgen.1007817","article-title":"Mutations in kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development","volume":"14","author":"Konjikusic","year":"2018","journal-title":"PLoS Genet"},{"issue":"12","key":"2024012714084956600_jbmr4738-bib-0029","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1038\/s41588-018-0260-3","article-title":"Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis","volume":"50","author":"Zhang","year":"2018","journal-title":"Nat Genet"},{"issue":"15","key":"2024012714084956600_jbmr4738-bib-0030","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.cub.2018.05.079","article-title":"The Reissner fiber in the cerebrospinal fluid controls morphogenesis of the body axis","volume":"28","author":"Cantaut-Belarif","year":"2018","journal-title":"Curr Biol"},{"issue":"12","key":"2024012714084956600_jbmr4738-bib-0031","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.cub.2020.04.015","article-title":"The Reissner fiber is highly dynamic In vivo and controls morphogenesis of the spine","volume":"30","author":"Troutwine","year":"2020","journal-title":"Curr Biol"},{"issue":"12","key":"2024012714084956600_jbmr4738-bib-0032","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1016\/j.cub.2020.04.020","article-title":"SCO-Spondin defects and neuroinflammation are conserved mechanisms driving spinal deformity across genetic models of idiopathic scoliosis","volume":"30","author":"Rose","year":"2020","journal-title":"Curr Biol"},{"key":"2024012714084956600_jbmr4738-bib-0033","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ydbio.2021.12.001","article-title":"The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish","volume":"482","author":"Wang","year":"2021","journal-title":"Dev Biol"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0034","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1038\/s41467-019-12276-5","article-title":"Characterizing rare and low-frequency height-associated variants in the Japanese population","volume":"10","author":"Akiyama","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"2024012714084956600_jbmr4738-bib-0035","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41588-019-0407-x","article-title":"A catalog of genetic loci associated with kidney function from analyses of a million individuals","volume":"51","author":"Wuttke","year":"2019","journal-title":"Nat Genet"},{"issue":"2","key":"2024012714084956600_jbmr4738-bib-0036","doi-asserted-by":"crossref","first-page":"E83","DOI":"10.1097\/BRS.0000000000003216","article-title":"Health-related quality of life in nonoperated patients with adolescent idiopathic scoliosis in the middle years: a mean 25-year follow-up study","volume":"45","author":"Watanabe","year":"2020","journal-title":"Spine"},{"key":"2024012714084956600_jbmr4738-bib-0037","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnbeh.2017.00035","article-title":"The role of early growth response 1 (EGR1) in brain plasticity and neuropsychiatric disorders","volume":"11","author":"Duclot","year":"2017","journal-title":"Front Behav Neurosci"},{"issue":"2","key":"2024012714084956600_jbmr4738-bib-0038","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0169-328X(01)00311-4","article-title":"Early activation of transcription factor expression in Schwann cells by progesterone","volume":"97","author":"Mercier","year":"2001","journal-title":"Brain Res Mol Brain Res"},{"key":"2024012714084956600_jbmr4738-bib-0039","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.reprotox.2014.10.010","article-title":"Egr1 is rapidly and transiently induced by estrogen and bisphenol A via activation of nuclear estrogen receptor-dependent ERK1\/2 pathway in the uterus","volume":"50","author":"Kim","year":"2014","journal-title":"Reprod Toxicol"},{"issue":"2","key":"2024012714084956600_jbmr4738-bib-0040","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/npp.2009.163","article-title":"Sex differences in social interaction in rats: role of the immediate-early gene zif268","volume":"35","author":"Stack","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0041","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hipo.22493","article-title":"Sex and strategy use matters for pattern separation, adult neurogenesis, and immediate early gene expression in the hippocampus","volume":"26","author":"Yagi","year":"2016","journal-title":"Hippocampus"},{"issue":"7","key":"2024012714084956600_jbmr4738-bib-0042","doi-asserted-by":"crossref","first-page":"452","DOI":"10.5483\/BMBRep.2011.44.7.452","article-title":"Estrogen receptor beta stimulates Egr-1 transcription via MEK1\/Erk\/Elk-1 cascade in C6 glioma cells","volume":"44","author":"Kim","year":"2011","journal-title":"BMB Rep"},{"issue":"4","key":"2024012714084956600_jbmr4738-bib-0043","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ocl.2006.09.010","article-title":"Sexual dimorphism in adolescent idiopathic scoliosis","volume":"37","author":"Raggio","year":"2006","journal-title":"Orthop Clin North Am"},{"issue":"1","key":"2024012714084956600_jbmr4738-bib-0044","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11832-012-0457-4","article-title":"Epidemiology of adolescent idiopathic scoliosis","volume":"7","author":"Konieczny","year":"2013","journal-title":"J Child Orthop"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/1\/144\/55455559\/jbmr4738.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/1\/144\/55455559\/jbmr4738.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:46:34Z","timestamp":1710326794000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/38\/1\/144-153\/7499979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,11,7]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4738","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4738\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4738\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4738\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4738\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4738\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4738\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4738\/v2\/response1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2022-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}