{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:35:23Z","timestamp":1789925723149,"version":"4.0.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Bone &amp; Mineral Res"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    During the menopause transition (MT), lean mass decreases and fat mass increases. We examined the associations of these body composition changes during the MT (2\u2009years before to 2\u2009years after the final menstrual period) with bone mineral density (BMD) at the end of the MT and fracture after the MT. We included 539 participants from the Study of Women's Health Across the Nation who were not taking bone\u2010beneficial or bone\u2010detrimental medications before or during the MT. Using multivariable linear regression, we assessed the independent associations of % lean mass loss and % fat mass gain during the MT (mutually adjusted) with femoral neck (FN) and lumbar spine (LS) BMD at the end of the MT, adjusted for pre\u2010MT BMD, pre\u2010MT lean and fat mass, race\/ethnicity, Study of Women's Health Across the Nation (SWAN) study site, age, and cigarette use. We used Cox proportional hazards regression to quantify the relations of % lean loss and % fat gain during the MT with fracture after the MT. The Cox model was adjusted for the covariates above plus post\u2010MT use of bone\u2010detrimental medications, and censored at the first use of bone\u2010beneficial medications; we further controlled for FN or LS BMD at the end of the MT. Adjusted for covariates, each standard deviation (SD) (6.9%) increment in lean mass loss was associated with 0.010\u2009g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    lower FN BMD (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001); each SD (19.9%) increment in fat mass gain was related to 0.026\u2009g\/cm\n                    <jats:sup>2<\/jats:sup>\n                    greater FN (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.009) and LS (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.03) BMD. Each SD increment in lean mass loss and fat mass gain was associated with 63% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001) and 28% (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.05) greater fracture hazard after the MT; associations were essentially unchanged by BMD adjustment. MT\u2010related lean mass loss and fat mass gain were associated differentially with BMD; both were independently related to more fractures. Mitigating MT\u2010related body composition changes may reduce fracture risk. \u00a9 2022 The Authors.\n                    <jats:italic>Journal of Bone and Mineral Research<\/jats:italic>\n                    published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).\n                  <\/jats:p>","DOI":"10.1002\/jbmr.4759","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T10:43:41Z","timestamp":1671619421000},"page":"395-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Menopause\u2010Related Changes in Body Composition Are Associated With Subsequent Bone Mineral Density and Fractures: Study of Women's Health Across the Nation"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0695-7976","authenticated-orcid":false,"given":"Albert","family":"Shieh","sequence":"first","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at University of California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-6064","authenticated-orcid":false,"given":"Arun S.","family":"Karlamangla","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at University of California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie A.","family":"Karvonen\u2010Guttierez","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-1081","authenticated-orcid":false,"given":"Gail A.","family":"Greendale","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at University of California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124865"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.534"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz281"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab279"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4113"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0508-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-013-0083-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1476"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.4.721"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-1059-y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3190"},{"key":"e_1_2_9_13_1","first-page":"155","volume-title":"Advances in Clinical Chemistry","author":"Gomarasca M","year":"2020"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.017"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-012-0127-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-46-1-146"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000000406"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7445"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070207"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-019-05274-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05325-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201700067"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1780-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7112.841"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041007"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-005-0005-y"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00221"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi187"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780110609"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650101120"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.1.146"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01622199"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.01.015"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3710-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-3009-6"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1808-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070020"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00025-9"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4239"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.024"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2469"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2303"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.06.013"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119266594.ch50"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.11.1947"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11136"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)32137-2"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0543-5"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:46:42Z","timestamp":1710326802000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/38\/3\/395-402\/7610233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/jbmr.4759"],"URL":"https:\/\/doi.org\/10.1002\/jbmr.4759","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4759\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v2\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4759\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]},"assertion":[{"value":"2022-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}