{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:09:19Z","timestamp":1775063359181,"version":"3.50.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":1152,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":804,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Faes Farma, S.A. and Bruno Farmaceutici S.p.A."}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Vitamin D plays a major role in bone health and probably also in multiple extraskeletal acute and chronic diseases. Although supplementation with calcifediol, a vitamin D metabolite, has demonstrated efficacy and safety in short-term clinical trials, its effects after long-term monthly administration have been studied less extensively. This report describes the results of a 1-year, phase III-IV, double-blind, randomized, controlled, parallel, multicenter superiority clinical trial to assess the efficacy and safety of monthly calcifediol 0.266\u2009mg versus cholecalciferol 25,000\u2009IU (0.625\u2009mg) in postmenopausal women with vitamin D deficiency (25(OH)D\u2009&amp;lt;\u200920\u2009ng\/mL). A total of 303 women were randomized and 298 evaluated. Patients were randomized 1:1:1 to calcifediol 0.266\u2009mg\/month for 12\u00a0months (Group A1), calcifediol 0.266\u2009mg\/month for 4\u2009months followed by placebo for 8\u2009months (Group A2), and cholecalciferol 25,000\u2009IU\/month (0.625\u2009mg\/month) for 12\u00a0months (Group B). By month 4, stable 25(OH)D levels were documented with both calcifediol and cholecalciferol (intention-to-treat population): 26.8\u00a0\u00b1\u20098.5\u00a0ng\/mL (Group A1) and 23.1\u00a0\u00b1\u20095.4\u00a0ng\/mL (Group B). By month 12, 25(OH)D levels were 23.9\u00a0\u00b1\u20098.0\u2009ng\/mL (Group A1) and 22.4\u00a0\u00b1\u20095.5\u00a0ng\/mL (Group B). When calcifediol treatment was withdrawn in Group A2, 25(OH)D levels decreased to baseline levels (28.5\u00a0\u00b1\u20098.7\u00a0ng\/mL at month 4 versus 14.4\u00a0\u00b1\u20096.0\u2009ng\/mL at month 12). No relevant treatment-related safety issues were reported in any of the groups. The results confirm that long-term treatment with monthly calcifediol in vitamin D-deficient patients is effective and safe. The withdrawal of treatment leads to a pronounced decrease of 25(OH)D levels. Calcifediol presented a faster onset of action compared to monthly cholecalciferol. Long-term treatment produces stable and sustained 25(OH)D concentrations with no associated safety concerns. \u00a9 2023 Faes Farma SA. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4776","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T10:04:00Z","timestamp":1674209040000},"page":"471-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long-Term Treatment and Effect of Discontinuation of Calcifediol in Postmenopausal Women with Vitamin D Deficiency: A Randomized Trial"],"prefix":"10.1093","volume":"38","author":[{"given":"Jos\u00e9 Luis","family":"P\u00e9rez-Castrill\u00f3n","sequence":"first","affiliation":[{"name":"School of Medicine, Universidad de Valladolid Valladolid Spain"},{"name":"Department of Internal Medicine Hospital Universitario R\u00edo Hortega Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Due\u00f1as-Laita","sequence":"additional","affiliation":[{"name":"Clinical Toxicology Unit Hospital Universitario R\u00edo Hortega Valladolid Spain"},{"name":"School of Medicine, Universidad de Valladolid Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"G\u00f3mez-Alonso","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit Hospital Universitario Central de Asturias \u2013 ISPA Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"J\u00f3dar","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Universidad Europea Madrid Spain"},{"name":"Department of Endocrinology & Clinical Nutrition Hospital Universitario Quironsalud Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"del Pino-Montes","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hospital Universitario de Salamanca Salamanca Spain"},{"name":"School of Medicine, Universidad de Salamanca Salamanca Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-0592","authenticated-orcid":false,"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"FIRMO Foundation (Fondazione Italiana Ricerca sulle Malattie dell'Osso) Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cereto Castro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Quir\u00f3n Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Quesada-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"},{"name":"Physiopathology of Endocrine Vitamin D System Biotechnology and Aging Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gallego L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario Virgen Macarena Seville Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-0891","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Olmos Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Infection and Immunity Area Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL) Santander Spain"},{"name":"School of Medicine, Universidad de Cantabria Santander Spain"},{"name":"Internal Medicine Department Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Rosa","family":"Alhambra Exp\u00f3sito","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Unit Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"},{"name":"Physiopathology of Endocrine Vitamin D System Biotechnology and Aging Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba (IMIBIC) C\u00f3rdoba Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernat","family":"Galarraga","sequence":"additional","affiliation":[{"name":"Department of Medicine University of the Basque Country Leioa Spain"},{"name":"Department of Rheumatology Hospital Quir\u00f3nsalud Bizkaia Erandio Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Gonz\u00e1lez-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Infection and Immunity Area Instituto de Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IDIVAL) Santander Spain"},{"name":"School of Medicine, Universidad de Cantabria Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Neyro","sequence":"additional","affiliation":[{"name":"International Master on Climacteric and Menopause, Universidad de Madrid (UDIMA) Madrid Spain"},{"name":"Gynecology and Obstetrics Service Hospital Universitario Cruces Barakaldo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-3763","authenticated-orcid":false,"given":"Roger","family":"Bouillon","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases and Metabolism KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Hern\u00e1ndez-Herrero","sequence":"additional","affiliation":[{"name":"R&D and Innovation Department Faes Farma Leioa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Fern\u00e1ndez-Hernando","sequence":"additional","affiliation":[{"name":"R&D and Innovation Department Faes Farma Leioa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-0996","authenticated-orcid":false,"given":"Sandra P.","family":"Chinchilla","sequence":"additional","affiliation":[{"name":"R&D and Innovation Department Faes Farma Leioa Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"11","key":"2024012714092715100_jbmr4776-bib-0001","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41430-020-0558-y","article-title":"Vitamin D deficiency 2.0: an update on the current status worldwide","volume":"74","author":"Amrein","year":"2020","journal-title":"Eur J Clin Nutr"},{"issue":"7","key":"2024012714092715100_jbmr4776-bib-0002","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.3390\/nu12072097","article-title":"Immunologic effects of vitamin D on human health and disease","volume":"12","author":"Charoenngam","year":"2020","journal-title":"Nutrients"},{"issue":"6","key":"2024012714092715100_jbmr4776-bib-0003","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.3390\/nu14061168","article-title":"Calcifediol (25OH vitamin D3) deficiency: a risk factor from early to old age","volume":"14","author":"Bouillon","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"2024012714092715100_jbmr4776-bib-0004","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1359\/jbmr.090826","article-title":"Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men","volume":"25","author":"Cauley","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2024012714092715100_jbmr4776-bib-0005","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/jbmr.2536","article-title":"Serum 25-hydroxyvitamin D levels: variability, knowledge gaps, and the concept of a desirable range","volume":"30","author":"Fuleihan","year":"2015","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2024012714092715100_jbmr4776-bib-0006","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3945\/ajcn.115.120873","article-title":"Vitamin D deficiency in Europe: pandemic?","volume":"103","author":"Cashman","year":"2016","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"2024012714092715100_jbmr4776-bib-0007","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1136\/ard.2006.064071","article-title":"Assessment of non-vertebral fracture risk in postmenopausal women","volume":"66","author":"Roux","year":"2007","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"2024012714092715100_jbmr4776-bib-0008","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2024012714092715100_jbmr4776-bib-0009","first-page":"13050","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"Institute of Medicine","year":"2011"},{"issue":"5","key":"2024012714092715100_jbmr4776-bib-0010","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/ageing\/afu093","article-title":"National Osteoporosis Society vitamin D guideline summary","volume":"43","author":"Aspray","year":"2014","journal-title":"Age Ageing"},{"issue":"5","key":"2024012714092715100_jbmr4776-bib-0011","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.beem.2018.09.014","article-title":"Vitamin D insufficiency: definition, diagnosis and management","volume":"32","author":"Bouillon","year":"2018","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"2024012714092715100_jbmr4776-bib-0012","doi-asserted-by":"crossref","first-page":"P23","DOI":"10.1530\/EJE-18-0736","article-title":"Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European calcified tissue society","volume":"180","author":"Lips","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"2024012714092715100_jbmr4776-bib-0013","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s00198-014-2794-2","article-title":"Clinician's guide to prevention and treatment of osteoporosis","volume":"25","author":"Cosman","year":"2014","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024012714092715100_jbmr4776-bib-0014","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00198-018-4704-5","article-title":"Scientific advisory Board of the European Society for clinical and economic aspects of osteoporosis (ESCEO) and the committees of scientific advisors and National Societies of the international osteoporosis foundation (IOF). European guidance for the diagnosis and management of osteoporosis in postmenopausal women","volume":"30","author":"Kanis","year":"2019","journal-title":"Osteoporos Int"},{"issue":"1","key":"2024012714092715100_jbmr4776-bib-0015","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/2049-3258-72-32","article-title":"Effects of vitamin D in the elderly population: current status and perspectives","volume":"72","author":"Bruy\u00e8re","year":"2014","journal-title":"Arch Public Health"},{"issue":"340","key":"2024012714092715100_jbmr4776-bib-0016","doi-asserted-by":"crossref","first-page":"b5463","DOI":"10.1136\/bmj.b5463","article-title":"Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe","volume":"12","author":"DIPART (Vitamin D Individual Patient Analysis of Randomized Trials) Group","year":"2010","journal-title":"BMJ"},{"issue":"1","key":"2024012714092715100_jbmr4776-bib-0017","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1056\/NEJMoa1109617","article-title":"A pooled analysis of vitamin D dose requirements for fracture prevention","volume":"367","author":"Bischoff-Ferrari","year":"2012","journal-title":"N Engl J Med"},{"issue":"11","key":"2024012714092715100_jbmr4776-bib-0018","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S2213-8587(18)30265-1","article-title":"Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis","volume":"6","author":"Bolland","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2024012714092715100_jbmr4776-bib-0019","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.maturitas.2018.10.011","article-title":"Vitamin D supplementation for musculoskeletal health outcomes in adults - the end of the beginning?","volume":"122","author":"Abrahamsen","year":"2019","journal-title":"Maturitas"},{"key":"2024012714092715100_jbmr4776-bib-0020","article-title":"Executive summary clinical practice guideline of postmenopausal, glucocortcioid-induced and male osteoporosis (2022 update). Spanish Society for Bone and Mineral Metabolism Investigation (SEIOMM)","volume":"222","author":"Riancho","journal-title":"Rev Clin Esp (Barc)"},{"issue":"9","key":"2024012714092715100_jbmr4776-bib-0021","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.rce.2015.08.003","article-title":"Clinical practice guidelines for posmenopausal, glucocorticoid-induced and male osteoporosis. Spanish Society for Research on bone and mineral metabolism (3rd updated version 2014)","volume":"215","author":"Gonz\u00e1lez-Mac\u00edas","year":"2015","journal-title":"Rev Clin Esp"},{"issue":"8","key":"2024012714092715100_jbmr4776-bib-0022","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00198-018-4520-y","article-title":"Is calcifediol better than cholecalciferol for vitamin D supplementation?","volume":"29","author":"Quesada-Gomez","year":"2018","journal-title":"Osteoporosis Int"},{"issue":"10","key":"2024012714092715100_jbmr4776-bib-0023","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/jbmr.4387","article-title":"Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial","volume":"36","author":"P\u00e9rez-Castrill\u00f3n","year":"2021","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2024012714092715100_jbmr4776-bib-0024","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.3390\/nu11112778","article-title":"Effects of weekly supplementation of cholecalciferol and calcifediol among the oldest-old people: findings from a randomized pragmatic clinical trial","volume":"11","author":"Ruggiero","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"2024012714092715100_jbmr4776-bib-0025","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jn\/nxz209","article-title":"Supplemental 25-hydroxycholecalciferol is more effective than cholecalciferol in raising serum 25-hydroxyvitamin D concentrations in older adults","volume":"150","author":"Graeff-Armas","year":"2020","journal-title":"J Nutr"},{"issue":"2","key":"2024012714092715100_jbmr4776-bib-0026","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3390\/nu13020380","article-title":"Effects of different vitamin D supplementation schemes in post-menopausal women: a monocentric open-label randomized study","volume":"13","author":"Corrado","year":"2021","journal-title":"Nutrients"},{"key":"2024012714092715100_jbmr4776-bib-0027","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jsbmb.2016.01.014","article-title":"Vitamin D3 and calcidiol are not equipotent","volume":"164","author":"Navarro-Valverde","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"59","key":"2024012714092715100_jbmr4776-bib-0028","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2013.10.014","article-title":"Pharmacokinetics of oral vitamin D3 and calcifediol","volume":"1","author":"Jetter","year":"2014","journal-title":"Bone"},{"issue":"3","key":"2024012714092715100_jbmr4776-bib-0029","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.clnu.2017.03.029","article-title":"Dose\u2013response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: a randomized controlled trial in older adults","volume":"37","author":"Vaes","year":"2018","journal-title":"Clin Nutr"},{"issue":"1","key":"2024012714092715100_jbmr4776-bib-0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jphotobiol.2011.07.008","article-title":"A mathematical model for seasonal variability of vitamin D due to solar radiation","volume":"105","author":"Krzy\u015bcin","year":"2011","journal-title":"J Photochem Photobiol, B"},{"issue":"4","key":"2024012714092715100_jbmr4776-bib-0031","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/jbmr.1496","article-title":"Risk factors for prediction of inadequate response to antiresorptives","volume":"27","author":"D\u00edez-P\u00e9rez","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2024012714092715100_jbmr4776-bib-0032","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00198-016-3868-0","article-title":"Imminent risk of fracture after fracture","volume":"28","author":"Johansson","year":"2017","journal-title":"Osteoporos Int"},{"issue":"2","key":"2024012714092715100_jbmr4776-bib-0033","doi-asserted-by":"crossref","first-page":"e0246541","DOI":"10.1371\/journal.pone.0246541","article-title":"Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers","volume":"16","author":"Kim","year":"2021","journal-title":"PLoS One"},{"key":"2024012714092715100_jbmr4776-bib-0034","doi-asserted-by":"crossref","first-page":"106047","DOI":"10.1016\/j.jsbmb.2021.106047","article-title":"Validation of the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio as a biomarker of 25-hydroxyvitamin D3 clearance","volume":"217","author":"Hsu","year":"2022","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"7","key":"2024012714092715100_jbmr4776-bib-0035","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1002\/jbmr.387","article-title":"Vitamin D\u2013binding protein modifies the vitamin D\u2013bone mineral density relationship","volume":"26","author":"Powe","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2024012714092715100_jbmr4776-bib-0036","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/00365513.2013.869701","article-title":"Serum free and bio-available 25-hydroxyvitamin D correlate better with bone density than serum total 25-hydroxyvitamin D","volume":"74","author":"Johnsen","year":"2014","journal-title":"Scand J Clin Lab Invest"},{"issue":"8","key":"2024012714092715100_jbmr4776-bib-0037","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/bjsports-2016-097130","article-title":"Why don't serum vitamin D concentrations associate with BMD by DXA? A case of being \u2018bound\u2019 to the wrong assay? Implications for vitamin D screening","volume":"52","author":"Allison","year":"2018","journal-title":"Br J Sports Med"},{"issue":"1","key":"2024012714092715100_jbmr4776-bib-0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12891-020-3179-7","article-title":"Free vitamin D correlate better with bone mineral density and thoracolumbar junction osteoporotic vertebral fractures than serum vitamin D","volume":"21","author":"Chhantyal","year":"2020","journal-title":"BMC Musculoskelet Disord"},{"issue":"4","key":"2024012714092715100_jbmr4776-bib-0039","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.ecl.2017.07.013","article-title":"Current controversies: are free vitamin metabolite levels a more accurate assessment of vitamin D status than Total levels?","volume":"46","author":"Bikle","year":"2017","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3\u20135","key":"2024012714092715100_jbmr4776-bib-0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsbmb.2011.05.003","article-title":"The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation","volume":"126","author":"Wagner","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2024012714092715100_jbmr4776-bib-0041","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jsbmb.2015.12.018","article-title":"25-hydroxyvitamin D assays: potential interference from other circulating vitamin D metabolites","volume":"164","author":"Carter","year":"2016","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"2024012714092715100_jbmr4776-bib-0042","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/0003-4819-156-6-201203200-00005","article-title":"Dose response to vitamin D supplementation in postmenopausal women: a randomized trial","volume":"156","author":"Gallagher","year":"2012","journal-title":"Ann Intern Med"},{"issue":"4","key":"2024012714092715100_jbmr4776-bib-0043","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000450766","article-title":"Use of extended-release calcifediol to treat secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease","volume":"44","author":"Sprague","year":"2016","journal-title":"Am J Nephrol"},{"issue":"12","key":"2024012714092715100_jbmr4776-bib-0044","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4158\/EP13518.OR","article-title":"The vitamin d dose response in obesity","volume":"20","author":"Dhaliwal","year":"2014","journal-title":"Endocr Pract"},{"issue":"7","key":"2024012714092715100_jbmr4776-bib-0045","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3390\/nu14071483","article-title":"Clinical practice in the prevention, diagnosis and treatment of vitamin D deficiency: a central and eastern European expert consensus statement","volume":"14","author":"Pludowski","year":"2022","journal-title":"Nutrients"},{"issue":"6","key":"2024012714092715100_jbmr4776-bib-0046","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/jbmr.3686","article-title":"Obesity decreases hepatic 25-hydroxylase activity causing low serum 25-hydroxyvitamin D","volume":"34","author":"Roizen","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"2","key":"2024012714092715100_jbmr4776-bib-0047","first-page":"84","article-title":"SEIOMM recommendations on the prevention and treatment of vitamin D deficiency","volume":"13","author":"Casado","year":"2021","journal-title":"Rev Osteoporos Metab Miner"},{"key":"2024012714092715100_jbmr4776-bib-0048","author":"Agenzia Italiana del Farmaco"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbmr.4776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbmr.4776","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/4\/471\/55456035\/jbmr4776.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/4\/471\/55456035\/jbmr4776.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:47:02Z","timestamp":1710326822000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/38\/4\/471-479\/7499956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,1,20]]},"published-print":{"date-parts":[[2020,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4776","relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JBMR.4776\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JBMR.4776\/v2\/review1","asserted-by":"object"}]},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,12,1]]},"published":{"date-parts":[[2020,12,1]]},"assertion":[{"value":"2022-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}