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CKD mineral and bone disorder (CKD\u2013MBD) describes the dysregulation of mineral homeostasis, including hyperphosphatemia and elevated parathyroid hormone (PTH) secretion, skeletal abnormalities, and vascular calcification. CKD\u2013MBD impacts the oral cavity, with effects including salivary gland dysfunction, enamel hypoplasia and damage, increased dentin formation, decreased pulp volume, pulp calcifications, and altered jaw bones, contributing to clinical manifestations of periodontal disease and tooth loss. Underlying mechanisms are not fully understood, and CKD mouse models commonly require invasive procedures with high rates of infection and mortality. We aimed to characterize the dentoalveolar effects of an adenine diet (AD)\u2010induced CKD (AD\u2013CKD) mouse model. Eight\u2010week\u2010old C57BL\/6J mice were provided either a normal phosphorus diet control (CTR) or adenine and high\u2010phosphorus diet CKD to induce kidney failure. Mice were euthanized at 15\u2009weeks old, and mandibles were collected for micro\u2013computed tomography and histology. CKD mice exhibited kidney failure, hyperphosphatemia, and hyperparathyroidism in association with porous cortical bone in femurs. CKD mice showed a 30% decrease in molar enamel volume compared to CTR mice. Enamel wear was associated with reduced ductal components, ectopic calcifications, and altered osteopontin (OPN) deposition in submandibular salivary glands of CKD mice. Molar cusps in CKD mice were flattened, exposing dentin. Molar dentin\/cementum volume increased 7% in CKD mice and pulp volume decreased. Histology revealed excessive reactionary dentin and altered pulp\u2010dentin extracellular matrix proteins, including increased OPN. Mandibular bone volume fraction decreased 12% and bone mineral density decreased 9% in CKD versus CTR mice. Alveolar bone in CKD mice exhibited increased tissue\u2010nonspecific alkaline phosphatase localization, OPN deposition, and greater osteoclast numbers. AD\u2013CKD recapitulated key aspects reported in CKD patients and revealed new insights into CKD\u2010associated oral defects. This model has potential for studying mechanisms of dentoalveolar defects or therapeutic interventions. \u00a9 2023 The Authors. <jats:italic>Journal of Bone and Mineral Research<\/jats:italic> published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4829","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T10:55:28Z","timestamp":1684234528000},"page":"1192-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Dentoalveolar Alterations in an <scp>Adenine\u2010Induced<\/scp> Chronic Kidney Disease Mouse Model"],"prefix":"10.1093","volume":"38","author":[{"given":"Fatma F.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Division of Biosciences, College of Dentistry The Ohio State University  Columbus OH 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