{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:40:30Z","timestamp":1780450830857,"version":"3.54.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017094","name":"Department of Internal Medicine, University of Utah","doi-asserted-by":"publisher","award":["4\u20102018\u20101215"],"award-info":[{"award-number":["4\u20102018\u20101215"]}],"id":[{"id":"10.13039\/100017094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017094","name":"Department of Internal Medicine, University of Utah","doi-asserted-by":"publisher","award":["DUCD000002"],"award-info":[{"award-number":["DUCD000002"]}],"id":[{"id":"10.13039\/100017094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Bone &amp; Mineral Res"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A significant increase in the risk of hip fracture was observed in middle\u2010aged men living with human immunodeficiency virus (MLWH), almost a decade earlier than those without infection. Data regarding cortical and trabecular bone deficit of hip, an important determinant of bone strength, in MLWH are limited. Quantitative CT was performed in consecutive MLWH aged \u226530\u2009years between November 2017 and October 2018 at Severance Hospital, Seoul, Korea. Volumetric bone mineral density (vBMD) and cortical bone mapping parameters of hip (cortical thickness [CTh], cortical bone vBMD [CBMD], cortical mass surface density [CMSD], endocortical trabecular density [ECTD]) were compared to age\u2010matched and body mass index (BMI)\u2010matched controls (1:2) using a community\u2010based healthy adults cohort. Among 83 MLWH and 166 controls (mean age: 47.2\u2009years; BMI: 23.6\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ), MLWH had lower total hip vBMD (280\u2009\u00b1\u200941 versus 296\u2009\u00b1\u200941\u2009mg\/cm\n                    <jats:sup>3<\/jats:sup>\n                    ), CMSD (155 versus 160\u2009mg\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ), and ECTD (158 versus 175\u2009mg\/cm\n                    <jats:sup>3<\/jats:sup>\n                    ) than controls that remained robust after adjustment for covariates (adjusted \u03b2: total hip vBMD, \u221218.8; CMSD, \u22127.3; ECTD, \u221218.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 for all). Cortical bone mapping revealed localized deficit of CTh, CBMD, and CMSD in the anterolateral trochanteric region and femoral neck in MLWH compared to controls, with a more extensive ECTD deficit. In MLWH, lower CD4 T\u2010cell count (\/100 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    decrement) and protease inhibitor (PI)\u2010based regimen (versus non\u2010PI regimen) at the time of antiretroviral treatment initiation were associated with lower total hip vBMD (adjusted \u03b2 \u22127.5 for lower CD4 count; \u221228.3 for PI\u2010based regimen) and CMSD (adjusted \u03b2 \u22122.6 for lower CD4 count; \u221212.7 for PI\u2010based regimen;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05 for all) after adjustment for covariates including age, BMI, smoking, alcohol use, hepatitis C virus co\u2010infection, tenofovir exposure, and CT scanner types. MLWH had lower hip bone density with cortical and trabecular bone deficit compared to community\u2010dwelling controls. \u00a9 2023 American Society for Bone and Mineral Research (ASBMR).\n                  <\/jats:p>","DOI":"10.1002\/jbmr.4873","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T08:39:56Z","timestamp":1687768796000},"page":"1288-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cortical and Trabecular Bone Deficit in Middle\u2010Aged Men Living with\n                    <scp>HIV<\/scp>"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-1956","authenticated-orcid":false,"given":"Namki","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Severance Hospital, Endocrine Research Institute Yonsei University College of Medicine Seoul South Korea"},{"name":"Institute for Innovation in Digital Healthcare Yonsei University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Severance Hospital, AIDS Research Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Treece","sequence":"additional","affiliation":[{"name":"Department of Engineering University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Chang","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Innovation in Digital Healthcare Yonsei University Seoul South Korea"},{"name":"Department of Preventive Medicine Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Severance Hospital, AIDS Research Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-5638","authenticated-orcid":false,"given":"Yumie","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Severance Hospital, Endocrine Research Institute Yonsei University College of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00077-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.13139"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001493"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328361d241"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1968"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350919"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2069"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv147"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.115210"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6914.1248"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-022-06405-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2014.11.012"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2552"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2017016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.03.776"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090734"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0820-y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091904"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-018-0475-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(09)70882-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.06.024"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2018.01.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214508000000841"},{"issue":"1","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling 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