{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:27:28Z","timestamp":1757543248128,"version":"3.37.3"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Romosozumab treatment reduces the rate of hip fractures and increases hip bone density, increasing bone formation by inhibiting sclerostin protein. We studied the normal pattern of bone formation and osteocyte expression in the human proximal femur because it is relevant to both antisclerostin treatment effects and fracture. Having visualized and quantified buds of new bone formation in trabeculae, we hypothesized that they would coincide with areas of (a) higher mechanical stress and (b) low sclerostin expression by osteocytes. In patients with hip fracture, we visualized each bud of active modeling-based formation (forming minimodeling structure [FMiS]) in trabecular cores taken from different parts of the femoral head. Trabecular bone structure was also measured with high-resolution imaging. More buds of new bone formation (by volume) were present in the higher stress superomedial zone (FMiS density, N.FMiS\/T.Ar) than lower stress superolateral (p\u2009&amp;lt;\u20090.05), and inferomedial (p\u2009&amp;lt;\u20090.001) regions. There were fewer sclerostin expressing osteocytes close to or within FMiS. FMiS density correlated with greater amount, thickness, number, and connectivity of trabeculae (bone volume BV\/TV, r\u2009=\u20090.65, p\u2009&amp;lt;\u20090.0001; bone surface BS\/TV, r\u2009=\u20090.47, p\u2009&amp;lt;\u20090.01; trabecular thickness Tb.Th, r\u2009=\u20090.55, p\u2009&amp;lt;\u20090.001; trabecular number Tb.N, r\u2009=\u20090.47, p\u2009&amp;lt;\u20090.01; and connectivity density Conn.D, r\u2009=\u20090.40, p\u2009&amp;lt;\u20090.05) and lower trabecular separation (Tb.Sp, r\u2009=\u2009\u22120.56, p\u2009&amp;lt;\u20090.001). These results demonstrate modeling-based bone formation in femoral trabeculae from patients with hip fracture as a potential therapeutic target to enhance bone structure. \u00a9 2023 American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4898","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T11:35:06Z","timestamp":1691408106000},"page":"1603-1611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Buds of new bone formation within the Femoral Head of Hip Fracture Patients Coincide with Zones of Low Osteocyte Sclerostin"],"prefix":"10.1093","volume":"38","author":[{"given":"Hiroshige","family":"Sano","sequence":"first","affiliation":[{"name":"Uchino Orthopedic Clinic Niigata Japan"},{"name":"Niigata Bone Science Institute Niigata Japan"},{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-9505","authenticated-orcid":false,"given":"Tristan","family":"Whitmarsh","sequence":"additional","affiliation":[{"name":"Institute of Astronomy University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0643-7951","authenticated-orcid":false,"given":"Linda","family":"Skingle","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taketoshi","family":"Shimakura","sequence":"additional","affiliation":[{"name":"Niigata Bone Science Institute Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Niigata Bone Science Institute Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-4151","authenticated-orcid":false,"given":"Juliet E.","family":"Compston","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki E.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Niigata Bone Science Institute Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E. S.","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Cambridge Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,1]]},"reference":[{"key":"2024022211061940900_jbmr4898-bib-0001","first-page":"359","article-title":"Evidence that bone resorption precedes formation at the cellular level","volume":"12","author":"Takahashi","year":"1964","journal-title":"Henry Ford Hosp Med Bull"},{"key":"2024022211061940900_jbmr4898-bib-0002","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/206489a0","article-title":"Suggested sequential mode of control of changes in cell behaviour in adult bone remodelling","volume":"206","author":"Hattner","year":"1965","journal-title":"Nature"},{"key":"2024022211061940900_jbmr4898-bib-0003","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jcb.240550303","article-title":"Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone","volume":"55","author":"Parfitt","year":"1994","journal-title":"J Cell Biochem"},{"key":"2024022211061940900_jbmr4898-bib-0004","first-page":"232","article-title":"Cancellous bone minimodeling-based formation: a Frost, Takahashi legacy","volume":"7","author":"Jee","year":"2007","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"2024022211061940900_jbmr4898-bib-0005","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ar.1092260402","article-title":"Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff's law: the bone modeling problem","volume":"226","author":"Frost","year":"1990","journal-title":"Anat Rec"},{"key":"2024022211061940900_jbmr4898-bib-0006","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S8756-3282(02)00947-X","article-title":"Trabecular minimodeling in human iliac bone","volume":"32","author":"Kobayashi","year":"2003","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0007","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1359\/JBMR.051109","article-title":"A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest bone biopsy: early actions of teriparatide","volume":"21","author":"Lindsay","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0008","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1359\/jbmr.060314","article-title":"Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis","volume":"21","author":"Ma","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0009","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/jbmr.3309","article-title":"Remodeling- and modeling-based bone formation with Teriparatide versus Denosumab: a longitudinal analysis from baseline to 3 months in the AVA study","volume":"33","author":"Dempster","year":"2018","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0010","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/jbmr.3350","article-title":"Longitudinal effects of Teriparatide or Zoledronic acid on bone modeling- and remodeling-based formation in the SHOTZ study","volume":"33","author":"Dempster","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"11","key":"2024022211061940900_jbmr4898-bib-0011","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/jbmr.4704","article-title":"Distinct responses of modeling- and remodeling-based bone formation to the discontinuation of intermittent parathyroid hormone treatment in Ovariectomized rats","volume":"37","author":"Wang","year":"2022","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0012","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/ar.a.20214","article-title":"Cement lines of secondary osteons in human bone are not mineral-deficient: new data in a historical perspective","volume":"286","author":"Skedros","year":"2005","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"2024022211061940900_jbmr4898-bib-0013","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00198-017-4323-6","article-title":"Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption","volume":"29","author":"Doyle","year":"2018","journal-title":"Osteoporos Int"},{"key":"2024022211061940900_jbmr4898-bib-0014","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/jbmr.2152","article-title":"Tissue-level mechanisms responsible for the increase in bone formation and bone volume by sclerostin antibody","volume":"29","author":"Ominsky","year":"2014","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bone.2017.04.005","article-title":"Kinetic reconstruction reveals time-dependent effects of romosozumab on bone formation and osteoblast function in vertebral cancellous and cortical bone in cynomolgus monkeys","volume":"101","author":"Boyce","year":"2017","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0016","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/jbmr.3038","article-title":"Sclerostin antibody administration converts bone lining cells into active osteoblasts","volume":"32","author":"Kim","year":"2017","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0017","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.bone.2016.12.003","article-title":"Time course of disassociation of bone formation signals with bone mass and bone strength in sclerostin antibody treated ovariectomized rats","volume":"97","author":"Ma","year":"2017","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0018","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1096\/fj.05-4221fje","article-title":"Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation","volume":"19","author":"Poole","year":"2005","journal-title":"FASEB J"},{"key":"2024022211061940900_jbmr4898-bib-0019","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J Biol Chem"},{"key":"2024022211061940900_jbmr4898-bib-0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1359\/jbmr.061002","article-title":"Wnt but not BMP signaling is involved in the inhibitory action of Sclerostin on BMP-stimulated bone formation","volume":"22","author":"van Bezooijen","year":"2006","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0021","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/jbmr.70","article-title":"Sclerostin and the regulation of bone formation: effects in hip osteoarthritis and femoral neck fracture","volume":"25","author":"Power","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0022","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41574-018-0087-0","article-title":"Clinical advantages and disadvantages of anabolic bone therapies targeting the WNT pathway","volume":"14","author":"Appelman-Dijkstra","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2024022211061940900_jbmr4898-bib-0023","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41584-018-0153-y","article-title":"Overcoming natural Wnt inhibition to optimize therapy","volume":"15","author":"Sims","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2024022211061940900_jbmr4898-bib-0024","doi-asserted-by":"crossref","first-page":"116401","DOI":"10.1016\/j.bone.2022.116401","article-title":"Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice","volume":"160","author":"Koide","year":"2022","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0025","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fendo.2018.00088","article-title":"Evidence for ongoing modeling-based bone formation in human femoral head trabeculae via forming Minimodeling structures: a study in patients with fractures and arthritis","volume":"9","author":"Sano","year":"2018","journal-title":"Front Endocrinol"},{"key":"2024022211061940900_jbmr4898-bib-0026","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bone.2016.10.020","article-title":"Focal osteoporosis defects play a key role in hip fracture","volume":"94","author":"Poole","year":"2017","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0027","doi-asserted-by":"crossref","first-page":"12894","DOI":"10.1074\/jbc.RA118.002983","article-title":"Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice","volume":"293","author":"Dudakovic","year":"2018","journal-title":"J Biol Chem"},{"key":"2024022211061940900_jbmr4898-bib-0028","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1038\/s41598-018-21184-5","article-title":"Early changes of articular cartilage and subchondral bone in the DMM mouse model of osteoarthritis","volume":"8","author":"Fang","year":"2018","journal-title":"Sci Rep"},{"key":"2024022211061940900_jbmr4898-bib-0029","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2106\/00004623-197052030-00005","article-title":"Changes in trabecular pattern of the upper end of the femur as an index of osteoporosis","volume":"52","author":"Singh","year":"1970","journal-title":"J Bone Joint Surg Am"},{"issue":"7","key":"2024022211061940900_jbmr4898-bib-0030","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/jbmr.141","article-title":"Guidelines for assessment of bone microstructure in rodents using micro-computed tomography","volume":"25","author":"Bouxsein","year":"2010","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0031","first-page":"283","article-title":"Bone histomorphometry","volume":"80","author":"Vedi","year":"2003","journal-title":"Methods Mol Med"},{"key":"2024022211061940900_jbmr4898-bib-0032","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bone.2008.11.017","article-title":"Bone structure and remodelling in stroke patients: early effects of zoledronate","volume":"44","author":"Poole","year":"2009","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0033","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jbmr.1805","article-title":"Standardized nomenclature, symbols, and units for bone histomorphometry: a 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee","volume":"28","author":"Dempster","year":"2013","journal-title":"J. Bone Miner. Res."},{"key":"2024022211061940900_jbmr4898-bib-0034","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00198-011-1656-4","article-title":"Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered","volume":"23","author":"Moustafa","year":"2012","journal-title":"Osteoporos Int"},{"key":"2024022211061940900_jbmr4898-bib-0035","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bone.2011.10.025","article-title":"Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading","volume":"50","author":"Tu","year":"2012","journal-title":"Bone"},{"key":"2024022211061940900_jbmr4898-bib-0036","doi-asserted-by":"crossref","first-page":"35939","DOI":"10.1074\/jbc.M109.060335","article-title":"The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity","volume":"284","author":"Bonnet","year":"2009","journal-title":"J Biol Chem"},{"key":"2024022211061940900_jbmr4898-bib-0037","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jbmr.2222","article-title":"Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes","volume":"29","author":"Meakin","year":"2014","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0038","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1074\/jbc.M705092200","article-title":"Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost\/sclerostin","volume":"283","author":"Robling","year":"2008","journal-title":"J Biol Chem"},{"key":"2024022211061940900_jbmr4898-bib-0039","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00223-017-0246-7","article-title":"Co-expression of DKK-1 and Sclerostin in subchondral bone of the proximal femoral heads from osteoarthritic hips","volume":"100","author":"Zarei","year":"2017","journal-title":"Calcif Tissue Int"},{"key":"2024022211061940900_jbmr4898-bib-0040","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"2024022211061940900_jbmr4898-bib-0041","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2307\/2529309","article-title":"A general methodology for the analysis of experiments with repeated measurement of categorical data","volume":"33","author":"Koch","year":"1977","journal-title":"Biometrics"},{"key":"2024022211061940900_jbmr4898-bib-0042","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMoa1708322","article-title":"Romosozumab or alendronate for fracture prevention in women with osteoporosis","volume":"377","author":"Saag","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"2024022211061940900_jbmr4898-bib-0043","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/jbmr.4457","article-title":"Modeling-based bone formation after 2\u2009months of Romosozumab treatment: results from the FRAME clinical trial","volume":"37","author":"Eriksen","year":"2022","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0044","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01774015","article-title":"Stress distributions within the proximal femur during gait and falls: implications for osteoporotic fracture","volume":"5","author":"Lotz","year":"1995","journal-title":"Osteoporos Int"},{"key":"2024022211061940900_jbmr4898-bib-0045","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/jbmr.2199","article-title":"Cortical bone assessed with clinical computed tomography at the proximal femur","volume":"29","author":"Johannesdottir","year":"2014","journal-title":"J Bone Miner Res"},{"issue":"10","key":"2024022211061940900_jbmr4898-bib-0046","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.medengphy.2006.11.002","article-title":"Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality","volume":"29","author":"MacNeil","year":"2007","journal-title":"Med Eng Phys"},{"key":"2024022211061940900_jbmr4898-bib-0047","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bone.2016.10.019","article-title":"Effects of sclerostin antibodies in animal models of osteoporosis","volume":"96","author":"Ominsky","year":"2017","journal-title":"Bone"},{"issue":"9","key":"2024022211061940900_jbmr4898-bib-0048","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/jbmr.3735","article-title":"Bone-forming and antiresorptive effects of romosozumab in postmenopausal women with osteoporosis: bone histomorphometry and microcomputed tomography analysis after 2 and 12 months of treatment","volume":"34","author":"Chavassieux","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2024022211061940900_jbmr4898-bib-0049","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/jbmr.3451","article-title":"Prediction of fractures in men using bone microarchitectural parameters assessed by high-resolution peripheral quantitative computed tomography-the prospective STRAMBO study","volume":"33","author":"Szulc","year":"2018","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2024022211061940900_jbmr4898-bib-0050","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography","volume":"90","author":"Boutroy","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2024022211061940900_jbmr4898-bib-0051","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bone.2015.02.027","article-title":"Monitoring in vivo (re)modeling: a computational approach using 4D microCT data to quantify bone surface movements","volume":"75","author":"Birkhold","year":"2015","journal-title":"Bone"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/11\/1603\/56739151\/jbmr4898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/38\/11\/1603\/56739151\/jbmr4898.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:47:45Z","timestamp":1710341265000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/38\/11\/1603-1611\/7610450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":51,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,11,1]]},"published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.4898","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"type":"print","value":"0884-0431"},{"type":"electronic","value":"1523-4681"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"2023-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}