{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:57:31Z","timestamp":1791644251167,"version":"4.3.4"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":113,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funding was provided by INSERM"},{"name":"University Hospital of Lyon"}],"content-domain":{"domain":["asbmr.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>As epigenetic regulators of gene expression, circulating micro-RiboNucleic Acids\u00a0(miRNAs) have been described in several bone diseases as potential prognostic markers. The aim of our study was to identify circulating miRNAs potentially associated with the severity of osteogenesis imperfecta (OI) in three steps. We have screened by RNA sequencing for the miRNAs that were differentially expressed in sera of a small group of OI patients versus controls and then conducted a validation phase by RT-qPCR analysis of sera of a larger patient population. In the first phase of miROI, we found 79 miRNAs that were significantly differentially expressed. We therefore selected 19 of them as the most relevant. In the second phase, we were able to validate the significant overexpression of 8 miRNAs in the larger OI group. Finally, we looked for a relationship between the level of variation of the validated miRNAs and the clinical characteristics of OI. We found a significant difference in the expression of two microRNAs in those patients with dentinogenesis imperfecta. After reviewing the literature, we found 6 of the 8 miRNAs already known to have a direct action on bone homeostasis. Furthermore, the use of a miRNA-gene interaction prediction model revealed a 100% probability of interaction between 2 of the 8 confirmed miRNAs and COL1A1 and\/or COL1A2. This is the first study to establish the miRNA signature in OI, showing a significant modification of miRNA expression potentially involved in the regulation of genes involved in the physiopathology of OI. \u00a9 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).<\/jats:p>","DOI":"10.1002\/jbmr.4912","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T05:09:50Z","timestamp":1694840990000},"page":"1665-1678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dysregulation of MicroRNAs in Adult Osteogenesis Imperfecta: The miROI Study"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-9353","authenticated-orcid":false,"given":"Alexandre","family":"Mercier-Guery","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"},{"name":"Hospices Civils de Lyon, H\u00f4pital E. Herriot Service de Rhumatologie et Pathologie Osseuse Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Millet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Merle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Collet","sequence":"additional","affiliation":[{"name":"INSERM UMR1132, CHU Lariboisi\u00e8re Paris France"},{"name":"CHU Robert Debr\u00e9, Universit\u00e9 de Paris Cit\u00e9, D\u00e9partement de G\u00e9n\u00e9tique CHU Lariboisi\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Bagouet","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E. Herriot Service de Rhumatologie et Pathologie Osseuse Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Borel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-5316","authenticated-orcid":false,"given":"Elisabeth","family":"Sornay-Rendu","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-6697","authenticated-orcid":false,"given":"Pawel","family":"Szulc","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Vignot","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E. Herriot Service de Rhumatologie et Pathologie Osseuse Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gensburger","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E. Herriot Service de Rhumatologie et Pathologie Osseuse Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Fontanges","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon, H\u00f4pital E. Herriot Service de Rhumatologie et Pathologie Osseuse Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Croset","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-6385","authenticated-orcid":false,"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Lyon 1, INSERM UMR 1033; LYOS Pathophysiology, Diagnosis & Treatments of Musculoskeletal Disorders Lyon France"},{"name":"Hospices Civils de Lyon, H\u00f4pital E. 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