{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:30:13Z","timestamp":1768926613818,"version":"3.49.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2010,6,30]],"date-time":"2010-06-30T00:00:00Z","timestamp":1277856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The new US National Osteoporosis Foundation's (NOF's) Clinician's Guide to Prevention and Treatment of Osteoporosis includes criteria for recommending pharmacologic treatment based on history of hip or vertebral fracture, femoral neck or spine bone mineral density (BMD) T-scores of \u22122.5 or less, and presence of low bone mass at the femoral neck or spine plus a 10-year risk of hip fracture of 3% or greater or of major osteoporotic fracture of 20% or greater. The proportion of men who would be recommended for treatment by these guidelines is not known. We applied the NOF criteria for treatment to men participating in the Osteoporotic Fractures in Men Study (MrOS). To determine how the MrOS population differs from the general US population of Caucasian men aged 65 years and older, we compared men in MrOS with men who participated in the National Health and Nutrition Examination Survey (NHANES) III on criteria included in the NOF treatment guidelines that were common to both cohorts. Compared with NHANES III, men in MrOS had higher femoral neck BMD values. Application of NOF guidelines to MrOS data estimated that at least 34% of US white men aged 65 years and older and 49% of those aged 75 years and older would be recommended for drug treatment. Application of the new NOF guidelines would result in recommending a very large proportion of white men in the United States for pharmacologic treatment of osteoporosis, for many of whom the efficacy of treatment is unknown. \u00a9 2010 American Society for Bone and Mineral Research<\/jats:p>","DOI":"10.1002\/jbmr.55","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T16:30:12Z","timestamp":1265301012000},"page":"1506-1511","source":"Crossref","is-referenced-by-count":35,"title":["Estimates of the proportion of older white men who would be recommended for pharmacologic treatment by the new US national osteoporosis foundation guidelines"],"prefix":"10.1093","volume":"25","author":[{"given":"Meghan G","family":"Donaldson","sequence":"first","affiliation":[{"name":"San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy M","family":"Cawthon","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily Y","family":"Lui","sequence":"additional","affiliation":[{"name":"San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T","family":"Schousboe","sequence":"additional","affiliation":[{"name":"Park Nicollet Health Services and Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine E","family":"Ensrud","sequence":"additional","affiliation":[{"name":"University of Minnesota and CCDOR VA Medical Center, Department of Medicine, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent C","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Minnesota and CCDOR VA Medical Center, Department of Medicine, Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A","family":"Cauley","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa A","family":"Hillier","sequence":"additional","affiliation":[{"name":"Kaiser Permanente Center for Health Research , Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thuy T","family":"Dam","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Aging, Columbia University, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff R","family":"Curtis","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis M","family":"Black","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C","family":"Bauer","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S","family":"Orwoll","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University, Department of Medicine, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R","family":"Cummings","sequence":"additional","affiliation":[{"name":"University of California San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA, USA"},{"name":"San Francisco Coordinating Center, California Pacific Medical Center, San Francisco, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,6,30]]},"reference":[{"key":"2024020320131958100_bib1","volume-title":"Clinician's Guide to Prevention and Treatment of Osteoporosis","author":"National Osteoporosis Foundation","year":"2008"},{"key":"2024020320131958100_bib2","volume-title":"FRAX: WHO Fracture Risk Assessment Tool","author":"World Health Organisation","year":"2008"},{"key":"2024020320131958100_bib3","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1359\/jbmr.060708","article-title":"BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women","volume":"21","author":"Cummings","year":"2006","journal-title":"J Bone Miner Res."},{"key":"2024020320131958100_bib4","first-page":"S79","article-title":"Distribution and rate of clinical fracture in 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