{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:09:29Z","timestamp":1771880969669,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1987,4,1]],"date-time":"1987-04-01T00:00:00Z","timestamp":544233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In an attempt to further define the nature of the active metabolite in bone formation, a series of experiments were conducted whereby vitamin D metabolites were administered locally in vivo into the proximal epiphyseal growth plate of the tibiae of rachitic chicks. Local administration of 3 \u03bcg of 24,25(OH)2D3in vivo to D-deficient chicks resulted in disappearance of the rachitic lesions in the same leg. Administration of 1 \u03bcg 1,25(OH)2D3 in a similar manner failed to show any sign of healing. Injection of 5 \u03bcg 25(OH)D3 was followed by recovery from rickets in both the injected right leg and in the vehicle-injected left tibia, although the recovery was more pronounced in the injected leg. Lower doses of 0.3 or 1 \u03bcg 24,25(OH)2D3 failed to reverse the rachitic lesions and induced only minimal recovery. These findings suggest that 24,25(OH)2D3 at the higher doses has a direct local effect on cartilage and bone, while 1,25(OH)2D3 has no such effect in chicks. 25(OH)D3 is probably absorbed from the epiphyses into the blood stream and converted into the active metabolites, which were indeed detected in the blood to exert its systemic effects.<\/jats:p>","DOI":"10.1002\/jbmr.5650020203","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T18:26:36Z","timestamp":1265221596000},"page":"91-98","source":"Crossref","is-referenced-by-count":36,"title":["Healing of rachitic lesions in chicks by 24R,25-dihydroxycholecalciferol administered locally into bone"],"prefix":"10.1093","volume":"2","author":[{"given":"Cobi","family":"Lidor","sequence":"first","affiliation":[{"name":"Biochemistry Department, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Atkin","sequence":"additional","affiliation":[{"name":"Laboratory of Teratology, Department of Anatomy and Embryology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel"},{"name":"Morphology Unit, Ben-Gurion University of the Negev, BeerSheba, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asher","family":"Prof. Ornoy","sequence":"additional","affiliation":[{"name":"Laboratory of Teratology, Department of Anatomy and Embryology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Dekel","sequence":"additional","affiliation":[{"name":"Biochemistry Department, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Edelstein","sequence":"additional","affiliation":[{"name":"Biochemistry Department, The Weizmann Institute of Science, Rehovot, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,4,1]]},"reference":[{"key":"2024012712034691400_bib1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1210\/jcem-46-2-284","article-title":"Vitamin D metabolites and bone mineralization in man.","volume":"46","author":"Bordier","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"2024012712034691400_bib2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1210\/endo-102-4-1269","article-title":"Vitamin D and cartilage. 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Biological activity of 25-hydroxycholecalciferol and 24,25 and 1,25-dihydroxycholecalciferol on cultured growth plate chondrocytes.","volume":"102","author":"Corvol","year":"1978","journal-title":"Endocrinology"},{"key":"2024012712034691400_bib3","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1136\/bmj.1.6124.1382","article-title":"Is 24,25-hydroxycholecalciferol a calcium-regulating hormone in man?","volume":"1","author":"Kanis","year":"1978","journal-title":"Br Med J"},{"key":"2024012712034691400_bib4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1126\/science.684411","article-title":"Vitamin D: Two hydroxylated metabolites are required for normal chicken egg hatchability.","volume":"201","author":"Henry","year":"1978","journal-title":"Science"},{"key":"2024012712034691400_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/276517a0","article-title":"24R,25-Dihydroxyvitamin D is a metabolite of vitamin D essential for bone 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