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Phenytoin did not alter CT release from glands or C cells incubated in 1 mM Ca, but, when Ca was raised to 1.75 or 2.5 mM, a marked inhibitory effect of phenytoin was apparent. The inhibitory effect could be negated by including 10 \u03bcM BAY-K-8644 in the medium. Inhibitory effects on CT release also were obtained with 100 \u03bcM trifluoperazine or 100 \u03bcM nitrendipine, and these inhibitory effects also were counteracted by 10 \u03bcM BAY-K-8644. The results show that clinically relevant amounts of phenytoin can inhibit CT release, perhaps by interfering with C-cell Ca channels or by inhibiting calmodulin-dependent processes.<\/jats:p>","DOI":"10.1002\/jbmr.5650030215","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T18:17:34Z","timestamp":1265221054000},"page":"219-223","source":"Crossref","is-referenced-by-count":8,"title":["Inhibition by phenytoin of<i>in vitro<\/i>secretion of calcitonin from rat thyroid glands and cultured rat C cells"],"prefix":"10.1093","volume":"3","author":[{"given":"Cary W.","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jin","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia K.","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX 77550"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"2024012712211316000_bib1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-0028-1094275","article-title":"Some possible mechanisms of action of antiepileptic drugs","volume":"3","author":"Woodbury","year":"1970","journal-title":"Pharmakopsychiatr Neuropsychopharmakol"},{"key":"2024012712211316000_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0006-8993(77)90150-0","article-title":"The mechanism of action of diphenylhydantoin on invertebrate neurons. 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