{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:56:35Z","timestamp":1791111395991,"version":"4.1.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1988,12,1]],"date-time":"1988-12-01T00:00:00Z","timestamp":596937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"MRC"},{"DOI":"10.13039\/501100001280","name":"Horserace Betting Levy Board","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001280","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The concept of resorption preceding formation in a coupled response is well established as the normal sequence of remodeling in adult bone. So prevalent is this concept, however, that the idea of the direct activation of osteogenic modeling in normal adult bone is often ignored. This experiment documents the direct transformation of the normal, quiescent, adult periosteum to active bone formation. The osteogenic stimulus was provided by a single short period of dynamic loading. Periosteal activation and the production of new bone within 5 days of loading was unaccompanied by resorption or the presence of osteoclasts. We therefore conclude that an adult resting periosteum can become directly converted to formation as a physiologic response to an appropriate osteogenic stimulus without the need for resorption. To distinguish this process from remodeling we suggest it be called renewed modeling. It is notable that a single short exposure to an \u201costeogenic\u201d loading regime can influence the full cascade of cellular events between quiescence and active bone formation.<\/jats:p>","DOI":"10.1002\/jbmr.5650030610","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T13:11:21Z","timestamp":1265202681000},"page":"647-656","source":"Crossref","is-referenced-by-count":185,"title":["Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading"],"prefix":"10.1093","volume":"3","author":[{"given":"Matthew J.","family":"Pead","sequence":"first","affiliation":[{"name":"Department of Anatomy, The Royal Veterinary College, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Skerry","sequence":"additional","affiliation":[{"name":"Department of Anatomy, The Royal Veterinary College, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance E.","family":"Dr. Lanyon","sequence":"additional","affiliation":[{"name":"Department of Anatomy, The Royal Veterinary College, London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1988,12,1]]},"reference":[{"key":"2024012712190437700_bib1","volume-title":"Mathematical Elements of Bone Remodeling","author":"Frost","year":"1964"},{"key":"2024012712190437700_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/ajpa.1330280511","article-title":"The \u201cnew bone\u201d: Some anthropological potentials.","volume":"28","author":"Frost","year":"1985","journal-title":"Yearbook Phys Anthropol"},{"key":"2024012712190437700_bib3","volume-title":"Bone Histomorphometry Techniques and Interpretation","author":"Parfitt","year":"1983"},{"key":"2024012712190437700_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF02555223","article-title":"Does the mechanical usage inhibit bone \u201cremodeling\u201d?","volume":"41","author":"Jaworski","year":"1987","journal-title":"Calcif Tissue Int"},{"key":"2024012712190437700_bib5","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1007\/BF02406132","article-title":"The cellular basis of bone remodeling: The quantum concept re-examined in the light of recent advances in the cell biology of bone.","volume":"36","author":"Parfitt","year":"1984","journal-title":"Calcif Tissue Int"},{"key":"2024012712190437700_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0021-9290(82)90246-9","article-title":"Mechanically adaptive bone remodelling. 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