{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:43:22Z","timestamp":1778276602939,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1989,8,1]],"date-time":"1989-08-01T00:00:00Z","timestamp":617932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Reduced renal tubular reabsorption of phosphate of unknown etiology is characteristic of X-linked hypophosphatemia in both humans and mice. To test whether a humoral abnormality is involved in the renal effect, parabiosis was performed between Hyp and normal mice at 4 weeks of age. The normal mice joined to Hyp mice showed a progressive diminution of plasma phosphate over the next 3 weeks to approach the level of the Hyp mice. These normal mice had a greater renal phosphate excretion index (urine P\/plasma P\/urine creatinine) than normal-normal pairs, thus suggesting a reduced renal tubular reabsorption of phosphate. At the same time the expected rises in plasma calcium and plasma 1,25-dihydroxyvitamin D did not occur. There was a significant reduction in their femoral mineral content but not in their femoral length or body growth relative to normal-normal pairs. This change in renal handling of phosphate was specific since the urinary losses of potassium and magnesium were not significantly changed. Separation of normal-Hyp pairs 3 or 6 weeks after parabiosis caused the normal mice to achieve normal plasma phosphate levels within 24 h. At 48 h and 7 days after separation these normal mice had plasma phosphate levels higher than normal mice separated from normal-normal pairs. In summary, the data suggest the presence of a phosphaturic factor in the Hyp mice that can cross a parabiotic union into normal mice and induce many of the symptoms of X-linked hypophosphatemia.<\/jats:p>","DOI":"10.1002\/jbmr.5650040407","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T18:08:05Z","timestamp":1265220485000},"page":"493-500","source":"Crossref","is-referenced-by-count":169,"title":["Parabiosis suggests a humoral factor is involved in <i>X<\/i>-linked hypophosphatemia in mice"],"prefix":"10.1093","volume":"4","author":[{"suffix":"Jr","given":"Ralph A.","family":"Dr. Meyer","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, Marquette University School of Dentistry, 604 North 16th St., Milwaukee, WI 53233"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha H.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Marquette University School of Dentistry, 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