{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:37:31Z","timestamp":1780583851044,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["AG-04875"],"award-info":[{"award-number":["AG-04875"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RR-000585"],"award-info":[{"award-number":["RR-000585"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>ABSTRACT: The cellular mechanisms for bone loss in type I (postmenopausal) osteoporosis are highly controversial. We attempted to resolve this by assessing rates of formation and resorption of iliac cancellous bone by a new histomorphometric method in 89 women with osteoporosis (mean age + SD, 66 + 6 years) and in 32 carefully selected normal postmenopausal women (64 + 6 years). In the osteoporotic women, bone resorption rate was increased by 39% (P &amp;lt;0.05) at the cellular level and by 67% (P &amp;lt;0.05) at the tissue level, whereas bone formation was unchanged at the tissue level but decreased by 14% (P &amp;lt;0.01) at the cellular (osteoblast) level. This pronounced remodeling imbalance (P &amp;lt;0.001) was probably exacerbated by a 45% increase (P &amp;lt; 0.1) in activation frequency of new remodeling foci. These abnormalities were associated with a high rate of cancellous bone loss (median, 5.8%\/year versus 0.1%\/year in controls). Thus, accelerated loss of cancellous bone in type I osteoporosis results from the combination of increased bone resorption and inadequate compensation by bone formation.<\/jats:p>","DOI":"10.1002\/jbmr.5650050402","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T20:39:30Z","timestamp":1267043970000},"page":"311-319","source":"Crossref","is-referenced-by-count":301,"title":["Cancellous bone remodeling in type i (postmenopausal) osteoporosis: Quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels"],"prefix":"10.1093","volume":"5","author":[{"given":"Erik F.","family":"Eriksen","sequence":"first","affiliation":[{"name":"Endocrine Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MD 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MD 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MD 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Lawrence","family":"DR. RIGGS","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MD 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Cedel","sequence":"additional","affiliation":[{"name":"Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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