{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:02:59Z","timestamp":1762671779542},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To explore the influence of the immune system on the development of osteoporosis, 19 untreated postmenopausal women with osteoporosis were studied by means of quantitative histomorphometry of the ilium and an analysis of T lymphocyte subsets in the peripheral blood. Osteoporotic women had lower OKT3+ and OKT8+ counts and a higher OKT4+\/OKT8+ ratio than nonosteoporotic control subjects. Linear regression analyses disclosed that the age of subjects correlated with bone mineral density (BMD; r = \u22120.634, p &amp;lt; 0.01) and some of the histomorphometric parameters for bone formation (r = \u22120.694 to \u22120.467, p &amp;lt; 0.010.05). The number of OKT4+ cells showed weak but significant negative correlation with the parameters for bone resorption (r = \u22120.549 to \u22120.462, p &amp;lt; 0.05). In a multiple regression analysis, the advanced age, the increase in OKT3+, and the decrease in OKT4+ and OKT8+ counts were shown to be significant predictors for the decrease in BMD (R = 0.882, p &amp;lt;0.01). According to the regression formula obtained from the analysis, the parameters for bone formation were related only to the age of subjects whereas those for bone resorption were tightly associated with the number of OKT4+ and OKT8+ cells but not with the age of subjects. These results indicated that, in addition to the age factor, abnormalities of the peripheral T lymphocyte subsets, especially those of OKT4+ and OKT8+ cells, are closely associated with the decrease in bone mass in postmenopausal osteoporosis, supporting the causal relationship between T lymphocyte functions and the development of postmenopausal osteoporosis.<\/jats:p>","DOI":"10.1002\/jbmr.5650050413","type":"journal-article","created":{"date-parts":[[2010,2,24]],"date-time":"2010-02-24T19:35:25Z","timestamp":1267040125000},"page":"393-399","source":"Crossref","is-referenced-by-count":22,"title":["Quantitative bone histomorphometry and circulating t lymphocyte subsets in postmenopausal osteoporosis"],"prefix":"10.1093","volume":"5","author":[{"suffix":"M.D.","given":"Yasuo","family":"Imai","sequence":"first","affiliation":[{"name":"Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Tsunenari","sequence":"additional","affiliation":[{"name":"Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Fukase","sequence":"additional","affiliation":[{"name":"Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Fujita","sequence":"additional","affiliation":[{"name":"Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,4,1]]},"reference":[{"key":"2024012712380718400_bib1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198606263142605","article-title":"Involutional osteoporosis","volume":"314","author":"Riggs","year":"1986","journal-title":"N Engl J Med"},{"key":"2024012712380718400_bib2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1056\/NEJM198803313181305","article-title":"Local and systemic factors in the pathogenesis of osteoporosis","volume":"318","author":"Raisz","year":"1988","journal-title":"N Engl J Med"},{"key":"2024012712380718400_bib3","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1073\/pnas.81.7.2181","article-title":"Thymus-derived lymphocytes and their interactions with macrophages are required for the production of osteoclast-activating factor in the mouse","volume":"81","author":"Horowitz","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024012712380718400_bib4","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.4049\/jimmunol.136.7.2478","article-title":"Actions of recombinant interleukin 1, interleukin 2, and interferon-7 on bone resorption in vitro","volume":"136","author":"Gowen","year":"1986","journal-title":"J Immunol"},{"key":"2024012712380718400_bib5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/319516a0","article-title":"Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factors","volume":"319","author":"Bertolini","year":"1986","journal-title":"Nature"},{"key":"2024012712380718400_bib6","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/jcem-57-6-1308","article-title":"Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: Presence in monocytes and induction in T lymphocytes following activation","volume":"57","author":"Bhalla","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"2024012712380718400_bib7","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1172\/JCI110784","article-title":"Circulating bovine lymphocytes contain receptors for parathyroid hormone","volume":"71","author":"Yamamoto","year":"1983","journal-title":"J Clin Invest"},{"key":"2024012712380718400_bib8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/258325a0","article-title":"Investigation of cell lineage in bone using a chimaera of chick and quail embryonic tissue","volume":"258","author":"Kahn","year":"1975","journal-title":"Nature"},{"key":"2024012712380718400_bib9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1126\/science.1105786","article-title":"Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells","volume":"190","author":"Walker","year":"1975","journal-title":"Science"},{"key":"2024012712380718400_bib10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1210\/endo-115-1-50","article-title":"Inflammation-mediated osteopenia in the rat. 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