{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:38:58Z","timestamp":1790228338825,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1990,7,1]],"date-time":"1990-07-01T00:00:00Z","timestamp":646790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["(3.880-85)"],"award-info":[{"award-number":["(3.880-85)"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mouse calvaria-derived osteoblastlike cells have been shown to produce macrophage colony-stimulating factor (M-CSF). This factor may be involved in osteoclastogenesis and thus in bone resorption. In the present study we investigated whether the production of M-CSF was altered in the osteopetrotic mouse mutant strain op\/op, characterized by a decrease in osteoclast number and an impairment of bone resorption. Whole calvariae and cells, as well as skin and lung fibroblasts, of the op\/op mouse were found to produce no measurable M-CSF, in contrast to tissue and cells derived from normal littermates. M-CSF was identified by colony assay in semisolid media and by inhibition of the biologic activity with antiserum against M-CSF. Furthermore, the number of resident macrophages, identified by F4\/80 antigen (F4\/80 Ag) immunohistochemistry, was drastically decreased in bone and bone marrow of the op\/op mouse, but in skin these cells were normal in number and morphology. These findings suggest that both M-CSF and resident macrophages play a role in the mechanism of bone resorption. The op\/op mouse appears to be a valuable model to further investigate such a hypothesis.<\/jats:p>","DOI":"10.1002\/jbmr.5650050716","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T13:03:07Z","timestamp":1265202187000},"page":"781-789","source":"Crossref","is-referenced-by-count":209,"title":["Rapid publication: Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic\n                    <i>op\/op<\/i>\n                    Mouse"],"prefix":"10.1093","volume":"5","author":[{"given":"R.","family":"Dr. Felix","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Cecchini","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Hofstetter","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.","family":"Elford","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stutzer","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fleisch","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1990,7,1]]},"reference":[{"key":"2024012712343281100_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00003086-198410000-00026","article-title":"Congenital osteopetrotic mutations as probes of the origin, structure, and function of osteoclasts","volume":"189","author":"Marks","year":"1984","journal-title":"Clin Orthop"},{"key":"2024012712343281100_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.jhered.a108657","article-title":"Osteopetrosis, a new recessive skeletal mutation on chromosome 12 of the mouse","volume":"67","author":"Marks","year":"1976","journal-title":"J Hered"},{"key":"2024012712343281100_bib3","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1084\/jem.156.5.1516","article-title":"Hematological characterization of congenital osteopetrosis in op\/op mouse. 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