{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:41:54Z","timestamp":1762954914398},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1990,11,1]],"date-time":"1990-11-01T00:00:00Z","timestamp":657417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effects of progesterone on oophorectomy-induced bone loss in aged rats were evaluated. Female rats aged 12 months were divided into three groups: (1) sham-operated controls (SHAM); (2) oophorectomized (OVX); (3) OVX rats treated with progesterone (OVX + PROG). After 20 weeks the dry weight, bone ash, and calcium content of femur, tibia, and fourth lumbar vertebra were significantly lower in OVX than in sham rats. These reductions did not occur in OVX rats treated with PROG. There was no difference in the bone composition between the control and progesterone-treated rats. Vertebral bone histomorphometry showed increased bone resorption as well as increased bone formation parameters in OVX rats. Progesterone treatment inhibited the increased resorption indices, but the bone formation remained elevated. The results indicate that progesterone therapy prevents the postovariectomy bone loss in aged rats. The protective effect of progesterone is mediated by inhibition of bone resorption while maintaining the increased bone formation. These findings suggest that progesterone alone may be a valuable agent for management of postmenopausal osteoporosis.<\/jats:p>","DOI":"10.1002\/jbmr.5650051109","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T18:01:30Z","timestamp":1265220090000},"page":"1143-1147","source":"Crossref","is-referenced-by-count":67,"title":["Effects of progesterone on postovariectomy bone loss in aged rats"],"prefix":"10.1093","volume":"5","author":[{"given":"E.I.","family":"Barengolts","sequence":"first","affiliation":[{"name":"Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.F.","family":"Gajardo","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.J.","family":"Rosol","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"D'Anza","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pena","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Botsis","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering, Mechanics and Metallurgy, College of Engineering, University of Illinois, Chicago, IL 60680"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.C.","family":"Kukreja","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA West Side Medical Center, and University of Illinois College of Medicine, Chicago, IL 60612"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,11,1]]},"reference":[{"key":"2024012712334309000_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1532-5415.1969.tb03169.x","article-title":"Changes in skeletal mass and fragility with castration in the rat: A model of osteoporosis","volume":"17","author":"Saville","year":"1969","journal-title":"J Am Geriatr Soc"},{"key":"2024012712334309000_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1210\/endo-115-2-507","article-title":"Evaluation of the pathogenesis of skeletal changes in ovariectomized rats","volume":"115","author":"Kalu","year":"1984","journal-title":"Endocrinology"},{"key":"2024012712334309000_bib3","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM198606263142605","article-title":"Involutional osteoporosis","volume":"314","author":"Riggs","year":"1986","journal-title":"N Engl J Med"},{"key":"2024012712334309000_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0002-9343(88)90425-1","article-title":"Research directions in osteoporosis","volume":"84","author":"Peck","year":"1988","journal-title":"Am J Med"},{"key":"2024012712334309000_bib5","doi-asserted-by":"crossref","first-page":"319","DOI":"10.7326\/0003-4819-102-3-319","article-title":"Long-term estrogen replacement therapy prevents bone loss and fractures","volume":"102","author":"Ettinger","year":"1985","journal-title":"Ann Intern Med"},{"key":"2024012712334309000_bib6","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0140-6736(76)92217-0","article-title":"Long-term prevention of postmenopausal osteoporosis by estrogen","volume":"1","author":"Lindsay","year":"1976","journal-title":"Lancet"},{"key":"2024012712334309000_bib7","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1056\/NEJM198711053171901","article-title":"Hip fracture and the use of estrogens in postmenopausal women. 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