{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:38Z","timestamp":1761059018506},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1990,12,1]],"date-time":"1990-12-01T00:00:00Z","timestamp":660009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Disodium pamidronate (APD) is a potent inhibitor of bone resorption, with less risk of defective mineralization than earlier bisphosphonates. We assessed the response to six spaced low-dose intravenous infusions of APD given at intervals of approximately 6 weeks followed by weekly infusions if bone turnover remained abnormal. Three groups of 10 patients were studied, each group receiving infusions of 15, 30, or 45 mg. Hydroxyproline excretion fell by 62% and alkaline phosphatase was reduced by 72%, with no difference between the dose levels. A total of 21 patients (70%) achieved normal levels of bone turnover, indicating that low-dose infusions of APD are a safe and effective treatment for Paget's disease.<\/jats:p>","DOI":"10.1002\/jbmr.5650051207","type":"journal-article","created":{"date-parts":[[2010,2,3]],"date-time":"2010-02-03T18:04:22Z","timestamp":1265220262000},"page":"1231-1235","source":"Crossref","is-referenced-by-count":21,"title":["Treatment of paget's disease with intermittent low-dose infusions of disodium pamidronate (APD)"],"prefix":"10.1093","volume":"5","author":[{"given":"Michael D.","family":"Stone","sequence":"first","affiliation":[{"name":"University Hospital, Nottingham NG7 2UH, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Barney","family":"Hawthorne","sequence":"additional","affiliation":[{"name":"University Hospital, Nottingham NG7 2UH, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kerr","sequence":"additional","affiliation":[{"name":"University Hospital, Nottingham NG7 2UH, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Webster","sequence":"additional","affiliation":[{"name":"University Hospital, Nottingham NG7 2UH, England"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hosking","sequence":"additional","affiliation":[{"name":"City Hospital, Nottingham NG5 1PB, England"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,12,1]]},"reference":[{"key":"2024012712321396400_bib1","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0140-6736(79)91318-7","article-title":"Treatment of Paget's disease of bone with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD)","volume":"1","author":"Frijlink","year":"1979","journal-title":"Lancet"},{"key":"2024012712321396400_bib2","first-page":"319","volume-title":"Bone and Mineral Research, Annual 1","author":"Fleisch","year":"1983"},{"key":"2024012712321396400_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF02408534","article-title":"Kinetic studies of bone and mineral metabolism during treatment with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) in rats","volume":"32","author":"Reitsma","year":"1980","journal-title":"Calcif Tissue Int"},{"key":"2024012712321396400_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF02405012","article-title":"Structure-activity relationship of various bisphosphonates","volume":"35","author":"Shinoda","year":"1983","journal-title":"Calcif Tissue Int"},{"key":"2024012712321396400_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2362.1982.tb00936.x","article-title":"Clinical and biological effects of low doses of 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) in Paget's disease of bone","volume":"11","author":"Heynen","year":"1982","journal-title":"Eur J Clin Invest"},{"key":"2024012712321396400_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00003086-198704000-00010","article-title":"Efficacious management with aminobisphosphonate (APD) in Paget's disease of bone","volume":"217","author":"Harinck","year":"1987","journal-title":"Clin Orthop Relat Res"},{"key":"2024012712321396400_bib7","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1136\/ard.45.12.1012","article-title":"Low dose intravenous 3-amino-1-hydroxypropylidene-1,1 bisphosphonate (APD) for the treatment of Paget's disease of bone","volume":"45","author":"Cantrill","year":"1986","journal-title":"Ann Rheum Dis"},{"key":"2024012712321396400_bib8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1136\/bmj.295.6609.1301","article-title":"Paget's disease of bone: Early and late resonses to three different modes of treatment with aminohydroxypropylidene bisphosphonate (APD)","volume":"295","author":"Harinck","year":"1988","journal-title":"Br Med J"},{"key":"2024012712321396400_bib9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jbmr.5650020108","article-title":"Paget's disease of bone treated in five days with AHPrBP (APD) per os","volume":"2","author":"Thi\u00e9baud","year":"1987","journal-title":"J Bone Min Res"},{"key":"2024012712321396400_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/jbmr.5650020402","article-title":"Intravenous aminopropylidene bisphosphonate (APD) in the treatment of Paget's bone disease","volume":"2","author":"Vega","year":"1987","journal-title":"J Bone Min Res"},{"key":"2024012712321396400_bib11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0041-008X(73)90219-6","article-title":"Intestinal absorption of disodium ethane-1-hydroxy-1,1-diphosphonate using a devolution technique","volume":"24","author":"Recker","year":"1933","journal-title":"Toxicol Appl Pharmacol"},{"key":"2024012712321396400_bib12","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1136\/bmj.288.6420.828-a","article-title":"Side-effects of disodium aminohydroxypropylidene diphosphonate (APD) during treatment of bone diseases","volume":"288","author":"Mautalen","year":"1984","journal-title":"Br Med J"},{"issue":"Suppl.","key":"2024012712321396400_bib13","first-page":"S23","article-title":"Bisphosphonates-history and experimental basis","volume":"8","author":"Fleisch","year":"1987","journal-title":"Bone"},{"key":"2024012712321396400_bib14","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1259\/0007-1285-60-717-849","article-title":"Radiological assessment of Paget's disease of bone after treatment with the bisphosphonates EHDP and APD","volume":"60","author":"Dodd","year":"1987","journal-title":"Br J Radiol"},{"key":"2024012712321396400_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0002-9343(88)80344-9","article-title":"A single infusion of the bisphosphonate AHPrBP as treatment of Paget's disease of bone","volume":"85","author":"Thi\u00e9baud","year":"1988","journal-title":"Am J Med"},{"key":"2024012712321396400_bib16","first-page":"525","volume-title":"Clinical Disorders of Bone and Mineral Metabolism","author":"Bijvoet","year":"1989"},{"key":"2024012712321396400_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/ageing\/1.3.168","article-title":"Serum alkaline phosphatase: The levels and patterns of isoenzymes in the hospitalized elderly","volume":"1","author":"Sharland","year":"1972","journal-title":"Age Ageing"},{"key":"2024012712321396400_bib18","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1136\/bmj.292.6529.1190","article-title":"Non steroidal anti-inflammatory drugs and serious gastrointestinal adverse reactions. 2","volume":"292","author":"Anonymous","year":"1986","journal-title":"Br Med J"},{"key":"2024012712321396400_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/8756-3282(87)90168-2","article-title":"Biochemical response to combination of disodium editronate with calcitonin in Paget's disease","volume":"8","author":"O'Donoghue","year":"1987","journal-title":"Bone"},{"key":"2024012712321396400_bib20","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0002-9343(85)90055-5","article-title":"Long term follow up of therapy with intermittent etidronate disodium in Paget's disease of bone","volume":"79","author":"Altman","year":"1985","journal-title":"Am J Med"},{"key":"2024012712321396400_bib21","first-page":"27","article-title":"Two modes of action of bisphosphonates on osteoclastic resorption of mineralized matrix","volume":"1","author":"Boonekamp","year":"1986","journal-title":"Bone Min"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650051207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/5\/12\/1231\/56430898\/5650051207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/5\/12\/1231\/56430898\/5650051207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:51:43Z","timestamp":1710341503000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/5\/12\/1231-1235\/7501872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12,1]]},"references-count":21,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1990,12,1]]},"published-print":{"date-parts":[[1990,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650051207","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,12,1]]},"published":{"date-parts":[[1990,12,1]]}}}