{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:25:20Z","timestamp":1760189120751},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"S1","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eighty one women with vertebral osteoporosis were treated for up to 2 years with fluoride administered either as monofluorophosphate (MFP, 200 mg\/day, i.e., 26.4 mg fluoride-ion) or sodium fluoride (NaF, 50 mg\/day, i.e., 22.6 mg fluoride-ion). All patients received calcium supplementation (1 g of Ca2+\/day) taken apart from NaF and in the same tablet for MFP. Despite almost similar fluoride dosage of both regimens, the early increase in the bone mineral density (BMD) of the lumbar spine was higher with MFP than with NaF, reaching 11% and 4%, respectively, at 1 year (p = 0.007), and 21% and 6%, respectively, at 18 months (p &amp;lt; 0.001). The incidence of lower extremity pain syndrome related to benign stress microfactures was also higher with MFP than with NaF (35% and 15%, respectively, p &amp;lt; 0.01). Urinary fluoride levels were higher in the MFP than in the NaF group (9.6 \u00b1 3.5 vs. 6.8 \u00b1 3.4 at one year, p = 0.003), suggesting that this difference in efficacy and tolerance is related to a better bioavailability of fluoride provided by MFP than by NaF. The occurrence of a stress microfracture could not be predicted by any clinical, biochemical, or densitometric parameter before treatment, but patients presenting with a stress microfracture during the course of the treatment had a higher gain in bone mass than those without stress fractures (at 1 yr+11 vs. +5%, p = 0.03 and at 18 months +18 vs. +6.9%, p &amp;lt; 0.02). In conclusion, there is a clear correlation between the efficacy and the occurrence of side effects of fluoride therapy in osteoporosis. In addition to the dose, the bioavailability of the fluoride salt may play a critical role in the magnitude of the response and should be taken into account when establishing the optimum therapeutic dose, as the therapeutic window may be narrow.<\/jats:p>","DOI":"10.1002\/jbmr.5650051322","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T22:41:27Z","timestamp":1267137687000},"page":"S143-S147","source":"Crossref","is-referenced-by-count":23,"title":["Journal of Bone and Mineral Research"],"prefix":"10.1093","volume":"5","author":[{"given":"P. D.","family":"DR. Delmas","sequence":"first","affiliation":[{"name":"INSERM Unit 234, Department of Rheumatology and Metabolic Bone Diseases, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Dupuis","sequence":"additional","affiliation":[{"name":"INSERM Unit 234, Department of Rheumatology and Metabolic Bone Diseases, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Duboeuf","sequence":"additional","affiliation":[{"name":"INSERM Unit 234, Department of Rheumatology and Metabolic Bone Diseases, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Chapuy","sequence":"additional","affiliation":[{"name":"INSERM Unit 234, Department of Rheumatology and Metabolic Bone Diseases, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Meunier","sequence":"additional","affiliation":[{"name":"INSERM Unit 234, Department of Rheumatology and Metabolic Bone Diseases, H\u00f4pital E. Herriot, Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"2024012712361549300_bib1","first-page":"415","volume-title":"Osteoporosis: Etiology, Diagnosis, and Management","author":"Eriksen","year":"1988"},{"key":"2024012712361549300_bib2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.6623079","article-title":"Fluoride directly stimulates proliferation and alkaline phosphatase activity of bone-forming cells","volume":"222","author":"Farley","year":"1983","journal-title":"Science"},{"key":"2024012712361549300_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0030-5898(20)31375-4","article-title":"Treatment of osteoporosis with fluoride, calcium and vitamin D","volume":"12","author":"Briancon","year":"1981","journal-title":"Orthop Clin North Am"},{"key":"2024012712361549300_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1210\/jcem-52-4-751","article-title":"Three-year changes in bone mineral mass of postmenopausal osteoporotic patients based on neutron activation analysis of the central third of the skeleton","volume":"52","author":"Harrison","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"2024012712361549300_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF02556692","article-title":"The effect of fluoride and calcium on spinal bone mineral content: a controlled, prospective (3 years) study","volume":"40","author":"Hansson","year":"1987","journal-title":"Calcif Tiss Int"},{"key":"2024012712361549300_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/8756-3282(87)90013-5","article-title":"Monitoring fluoride therapy in osteoporosis by dual photon absorptiometry","volume":"8","author":"Raymakers","year":"1987","journal-title":"Bone"},{"key":"2024012712361549300_bib7","first-page":"817","volume-title":"Osteoporosis 1987","author":"Riggs","year":"1987"},{"key":"2024012712361549300_bib8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/8756-3282(86)90018-9","article-title":"Long-term fluoride therapy of postmenopausal osteoporosis","volume":"7","author":"Dambacher","year":"1986","journal-title":"Bone"},{"key":"2024012712361549300_bib9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF00352619","article-title":"Trabecular stress fractures during fluoride therapy for osteoporosis","volume":"14","author":"Schnitzler","year":"1985","journal-title":"Skeletal Radiol"},{"issue":"Supp. 1","key":"2024012712361549300_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000260728","article-title":"Monofluorophosphate physiology: general considerations","volume":"17","author":"Ericsson","year":"1983","journal-title":"Caries Res"},{"key":"2024012712361549300_bib11","first-page":"1843","article-title":"Osteoporosetherapie mit natrium monofluorphosphat und kalzium","volume":"34","author":"Dressier","year":"1984","journal-title":"Therapiewoche"},{"key":"2024012712361549300_bib12","first-page":"379","article-title":"Kombinierte fluoridtherapie der primaren osteoporose","volume":"105","author":"Ringe","year":"1987","journal-title":"Fortschr Med"},{"key":"2024012712361549300_bib13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(88)92834-6","article-title":"Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis","volume":"ii","author":"Mamelle","year":"1988","journal-title":"Lancet"},{"key":"2024012712361549300_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/8756-3282(88)90033-6","article-title":"Comparison of bone mass measured by histomorphometry on iliac bone biopsy and by dual photon absorptiometry of the lumbar spine","volume":"9","author":"Delmas","year":"1988","journal-title":"Bone"},{"key":"2024012712361549300_bib15","first-page":"1595","article-title":"Mesure de la densite osseuse lombaire par absorptiometrie biphotonique. Son interet en pathologie osseuse","volume":"64","author":"Delmas","year":"1988","journal-title":"Sem Hop Paris"},{"key":"2024012712361549300_bib16","first-page":"1751","article-title":"Errors in longitudinal measurements of bone mineral: effect of source strength in single and dual photon absorptiometry","volume":"28","author":"Dunn","year":"1987","journal-title":"J Nucl Med"},{"key":"2024012712361549300_bib17","first-page":"1","article-title":"Physiologie et pharmacocinetique du monofluorophosphate disodique-carbonate de calcium","volume":"2","author":"Rouveix","year":"1988","journal-title":"Lettre du Pharmacologue"},{"key":"2024012712361549300_bib18","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF00352619","article-title":"Trabecular stress fractures during fluoride therapy for osteoporosis","volume":"14","author":"Schnitzler","year":"1985","journal-title":"Skeletal Radiol"},{"key":"2024012712361549300_bib19","first-page":"262","volume-title":"Osteoporosis 1987","author":"Einhorn","year":"1987"}],"container-title":["Journal of Bone and Mineral Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbmr.5650051322","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/5\/S1\/S143\/56430846\/5650051322.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jbmr\/article-pdf\/5\/S1\/S143\/56430846\/5650051322.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T14:51:49Z","timestamp":1710341509000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jbmr\/article\/5\/S1\/S143-S147\/7502308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3,1]]},"references-count":19,"journal-issue":{"issue":"S1","published-online":{"date-parts":[[1990,3,1]]},"published-print":{"date-parts":[[1990,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/jbmr.5650051322","relation":{},"ISSN":["0884-0431","1523-4681"],"issn-type":[{"value":"0884-0431","type":"print"},{"value":"1523-4681","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,3,1]]},"published":{"date-parts":[[1990,3,1]]}}}