{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:04:38Z","timestamp":1710374678750},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"S1","license":[{"start":{"date-parts":[[1990,3,1]],"date-time":"1990-03-01T00:00:00Z","timestamp":636249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The possible effects of fluoride in inducing fractures were studied in 61 patients treated with sodium fluoride (NaF), 40\u201360 mg daily in combination with calcium and vitamin D. Nine patients developed the fluoride-(F) related lower extremity pain syndrome. Four other patients had stress fractures associated with trauma. Seven of the 61 patients had 10 upper femur fractures of which 5 were stress fractures. The bone mineral mass of the central skeleton including the hips was measured by neutron activation and the results expressed as a calcium bone index (CaBI) which normalizes the results to that of young adults of the same body size (normal range 0.75\u20131.2). At the time of hip fracture, 4 patients with a minimal increase in bone mass (mean \u0394CaBI 0.01) had 4 femur fractures and 3 patients with a marked increase (mean \u0394CaBI 0.24) had 6. The 7 patients with upper femur fractures at 4 years had a significantly higher bone fluoride retention, 30 mg\/g Ca compared with 23.9 mg\/g Ca for the other 54 (p &amp;lt; 0.02) and were older, 73.1 versus 64.2 years (p &amp;lt; 0.01). Using all 61 fluoride-treated patients, femur fractures\/patient were significantly correlated to bone fluoride (p &amp;lt; 0.05) and to age (p &amp;lt; 0.05). By partial correlation, only the correlation between hip fractures\/patient and bone fluoride remained significant after controlling for the effect of age (p &amp;lt; 0.05). These results suggest that fluoride therapy may be implicated in the pathogenesis of hip fractures which may occur in treated patients despite a rapid, marked increase in bone mass. The lower extremity pain syndrome is not frequently associated with stress fractures in this study.<\/jats:p>","DOI":"10.1002\/jbmr.5650051333","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T21:43:36Z","timestamp":1267134216000},"page":"S217-S222","source":"Crossref","is-referenced-by-count":4,"title":["Journal of Bone and Mineral Research"],"prefix":"10.1093","volume":"5","author":[{"given":"T. A.","family":"DR. Bayley","sequence":"first","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Harrison","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. M.","family":"Murray","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Josse","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Sturtridge","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. P. H.","family":"Pritzker","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Strauss","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vieth","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Goodwin","sequence":"additional","affiliation":[{"name":"St. Joseph's Health Centre, Toronto General Hospital, St. Michael's Hospital, Departments of Medicine and Pathology, and The Bone and Mineral Group, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,3,1]]},"reference":[{"key":"2024012712352661100_bib1","first-page":"366","volume-title":"Bone and Mineral Research Annual 2","author":"Riggs","year":"1984"},{"key":"2024012712352661100_bib2","first-page":"481","article-title":"Fluoride in osteoporosis-vertebral, but no femoral fracture protection","volume":"36","author":"Gutteridge","year":"1984","journal-title":"Calcif Tiss Int"},{"key":"2024012712352661100_bib3","first-page":"705","author":"Gutteridge","year":"1984"},{"key":"2024012712352661100_bib4","first-page":"871","volume-title":"Osteoporosis 1987","author":"Gutteridge","year":"1987"},{"key":"2024012712352661100_bib5","first-page":"629","author":"Schnitzler","year":"1984"},{"key":"2024012712352661100_bib6","first-page":"560","article-title":"Mechanism of acute lower extremity pain syndrome in fluoride treated osteoporotic patients","volume":"80","author":"O'Duffy","year":"1986","journal-title":"Am J Med"},{"key":"2024012712352661100_bib7","first-page":"817","volume-title":"Osteoporosis 1987","author":"Riggs","year":"1987"},{"key":"2024012712352661100_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/jbmr.5650020207","article-title":"Incidence of hip fractures in osteoporotic women treated with sodium fluoride","volume":"2","author":"Riggs","year":"1987","journal-title":"J Bone Min 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1","key":"2024012712352661100_bib12","first-page":"S27","article-title":"Fluoride treatment of postmenopausal osteoporosis: age, renal function, and other clinical factors in the osteogenic response 1990","volume":"5","author":"Murray","journal-title":"J Bone Min Res"},{"issue":"2","key":"2024012712352661100_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1148\/radiology.159.2.3961177","article-title":"Osteoporosis: radiographic detection of fluoride-induced extra-axial bone formation","volume":"159","author":"Schulz","year":"1986","journal-title":"Radiology"}],"container-title":["Journal of Bone and Mineral 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